RFC4
replication factor C subunit 4
Summary
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Known Variants22 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2066500 | 3:186,507,922 | C/T | — | benign |
| rs944896380 | 3:186,507,948 | T/C | — | uncertain significance |
| rs112452568 | 3:186,508,002 | G/C | — | uncertain significance |
| rs749725448 | 3:186,508,004 | T/A | — | uncertain significance |
| rs1722052552 | 3:186,508,010 | A/T | — | uncertain significance |
| rs771112894 | 3:186,508,030 | C/G | — | uncertain significance |
| rs774423112 | 3:186,508,034 | T/C | — | uncertain significance |
| rs76048542 | 3:186,508,138 | C/G | — | uncertain significance |
| rs756915494 | 3:186,508,170 | C/T | — | uncertain significance |
| rs2108466312 | 3:186,508,185 | G/A | — | uncertain significance |
| rs1722073493 | 3:186,508,192 | T/C | — | uncertain significance |
| rs187852064 | 3:186,509,516 | C/G | — | uncertain significance |
| rs193178391 | 3:186,509,524 | T/C | — | uncertain significance |
| rs775247271 | 3:186,510,359 | A/G | — | uncertain significance |
| rs376471242 | 3:186,510,653 | C/T | — | uncertain significance |
| rs764526307 | 3:186,512,453 | C/T | — | uncertain significance |
| rs148403533 | 3:186,512,516 | C/T | — | uncertain significance |
| rs747875532 | 3:186,512,541 | G/C | — | uncertain significance |
| rs187349496 | 3:186,515,561 | T/C | intron variant | — |
| rs2474004414 | 3:186,518,919 | A/G | — | uncertain significance |
| rs144428719 | 3:186,518,958 | G/C | — | uncertain significance |
| rs146612878 | 3:186,522,459 | G/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.