RGS11
regulator of G protein signaling 11
Summary
The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013]
Known Variants54 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs538383366 | 16:319,278 | C/T | — | uncertain significance |
| rs758577077 | 16:319,323 | G/C | — | uncertain significance |
| rs916194 | 16:319,398 | C/T | downstream gene variant | — |
| rs148909526 | 16:319,502 | C/T | — | likely benign |
| rs757464684 | 16:319,503 | G/A | — | uncertain significance |
| rs1374296910 | 16:320,566 | C/T | — | uncertain significance |
| rs768541429 | 16:320,590 | C/T | — | uncertain significance |
| rs199588869 | 16:320,644 | C/T | — | uncertain significance |
| rs373870484 | 16:320,744 | C/T | — | uncertain significance |
| rs2548454769 | 16:320,762 | G/C | — | uncertain significance |
| rs151200131 | 16:320,768 | G/A | — | uncertain significance |
| rs370263768 | 16:320,782 | G/A | — | uncertain significance |
| rs149964951 | 16:320,791 | C/T | — | uncertain significance |
| rs746233784 | 16:321,028 | C/T | — | likely benign |
| rs201188482 | 16:321,048 | C/G | — | uncertain significance |
| rs746430045 | 16:321,076 | G/A | — | uncertain significance |
| rs372283964 | 16:321,079 | G/A | — | uncertain significance |
| rs773881172 | 16:321,085 | T/A | — | uncertain significance |
| rs59594847 | 16:321,103 | G/C | splice region variant | — |
| rs757993002 | 16:321,213 | A/G | — | uncertain significance |
| rs148149079 | 16:321,226 | C/T | — | likely benign |
| rs760798138 | 16:321,267 | G/A | — | uncertain significance |
| rs766417162 | 16:321,271 | C/T | — | likely benign |
| rs368956024 | 16:321,291 | C/G | — | uncertain significance |
| rs373018297 | 16:321,456 | C/T | — | uncertain significance |
| rs144460138 | 16:322,327 | A/G | downstream gene variant | — |
| rs201817421 | 16:322,917 | T/C | — | uncertain significance |
| rs541738418 | 16:322,918 | C/T | — | likely benign |
| rs1472683461 | 16:322,927 | C/T | — | uncertain significance |
| rs751718958 | 16:323,476 | G/T | — | uncertain significance |
| rs756494646 | 16:323,480 | G/C | — | uncertain significance |
| rs149598088 | 16:323,482 | C/G | — | uncertain significance |
| rs757480093 | 16:323,555 | C/T | — | uncertain significance |
| rs1272625485 | 16:323,767 | G/T | — | uncertain significance |
| rs142683229 | 16:323,799 | G/T | — | uncertain significance |
| rs376499869 | 16:323,823 | C/T | — | likely benign |
| rs150330840 | 16:324,069 | G/A | — | uncertain significance |
| rs757411764 | 16:324,074 | C/T | — | uncertain significance |
| rs745943037 | 16:324,077 | A/C | — | uncertain significance |
| rs1432763875 | 16:324,231 | G/A | — | uncertain significance |
| rs138989898 | 16:324,261 | G/A | — | uncertain significance |
| rs373649420 | 16:324,264 | G/A | — | uncertain significance |
| rs764683385 | 16:324,989 | G/A | — | uncertain significance |
| rs367699875 | 16:325,034 | G/A | — | uncertain significance |
| rs190686593 | 16:325,035 | A/G | — | likely benign |
| rs1222071721 | 16:325,326 | G/T | — | uncertain significance |
| rs752441044 | 16:325,414 | G/A | — | uncertain significance |
| rs750231818 | 16:325,450 | T/C | — | uncertain significance |
| rs2548474455 | 16:325,482 | A/C | — | uncertain significance |
| rs377431546 | 16:325,483 | C/T | — | uncertain significance |
| rs1302778561 | 16:325,890 | G/A | — | uncertain significance |
| rs779845934 | 16:325,894 | C/T | — | likely benign |
| rs3743880 | 16:326,027 | C/T | regulatory region variant | — |
| rs3809654 | 16:326,525 | A/C | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.