RGS3
regulator of G protein signaling 3
Summary
This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]
Known Variants92 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs113797410 | 9:116,222,555 | C/T | missense variant | — |
| rs201175305 | 9:116,224,016 | A/G | — | likely benign |
| rs1829485308 | 9:116,224,307 | C/T | — | uncertain significance |
| rs1197778860 | 9:116,224,314 | C/G | — | uncertain significance |
| rs781339051 | 9:116,224,328 | C/T | — | uncertain significance |
| rs373588536 | 9:116,224,370 | C/T | — | uncertain significance |
| rs769080747 | 9:116,241,788 | A/G | — | uncertain significance |
| rs148356011 | 9:116,245,354 | G/A | — | uncertain significance |
| rs563885583 | 9:116,245,387 | C/T | — | uncertain significance |
| rs770598136 | 9:116,246,469 | G/A | — | likely benign |
| rs72761903 | 9:116,246,654 | T/C | regulatory region variant | — |
| rs534314397 | 9:116,258,109 | C/T | — | uncertain significance |
| rs751549571 | 9:116,259,636 | C/T | — | uncertain significance |
| rs564374250 | 9:116,259,663 | C/T | — | uncertain significance |
| rs747531708 | 9:116,259,676 | C/T | — | likely benign |
| rs769951740 | 9:116,260,328 | G/A | — | uncertain significance |
| rs7856515 | 9:116,264,982 | A/C | regulatory region variant | — |
| rs944185036 | 9:116,267,756 | T/C | — | uncertain significance |
| rs1409669500 | 9:116,267,770 | G/A | — | uncertain significance |
| rs773989606 | 9:116,268,673 | C/A | — | uncertain significance |
| rs80204071 | 9:116,269,303 | T/G | intron variant | — |
| rs1831173273 | 9:116,269,586 | A/T | — | uncertain significance |
| rs753820589 | 9:116,269,604 | A/G | — | uncertain significance |
| rs749849310 | 9:116,269,614 | A/C | — | uncertain significance |
| rs761686605 | 9:116,269,698 | G/A | — | uncertain significance |
| rs765040245 | 9:116,269,704 | A/G | — | uncertain significance |
| rs754666918 | 9:116,269,716 | A/T | — | uncertain significance |
| rs2490780934 | 9:116,269,739 | C/G | — | uncertain significance |
| rs143439522 | 9:116,269,770 | G/A | — | uncertain significance |
| rs2490781753 | 9:116,269,830 | G/A | — | uncertain significance |
| rs1340669139 | 9:116,269,847 | G/A | — | uncertain significance |
| rs1200461238 | 9:116,269,853 | T/C | — | uncertain significance |
| rs2490782098 | 9:116,269,871 | A/C | — | uncertain significance |
| rs1285631570 | 9:116,269,901 | C/T | — | likely benign |
| rs752018623 | 9:116,276,774 | G/T | — | uncertain significance |
| rs116666638 | 9:116,276,942 | C/T | — | likely benign |
| rs2050866 | 9:116,278,240 | G/A | regulatory region variant | — |
| rs72761985 | 9:116,279,701 | G/T | regulatory region variant | — |
| rs781573879 | 9:116,279,839 | C/A | — | uncertain significance |
| rs138006273 | 9:116,285,267 | C/T | — | uncertain significance |
| rs773137637 | 9:116,285,276 | G/A | — | uncertain significance |
| rs12353541 | 9:116,292,207 | T/C | intron variant | — |
| rs1297830829 | 9:116,299,080 | C/T | — | uncertain significance |
| rs146280823 | 9:116,299,146 | C/T | — | uncertain significance |
| rs138522961 | 9:116,304,684 | A/G | intron variant | — |
| rs10981820 | 9:116,311,075 | C/T | regulatory region variant | — |
| rs201914907 | 9:116,345,820 | C/G | — | uncertain significance |
| rs2491121853 | 9:116,345,890 | A/G | — | uncertain significance |
| rs200827727 | 9:116,345,925 | G/A | — | uncertain significance |
| rs140906223 | 9:116,345,968 | T/C | — | benign |
| rs2491122879 | 9:116,345,989 | C/T | — | uncertain significance |
| rs367598846 | 9:116,346,014 | A/T | — | uncertain significance |
| rs138572508 | 9:116,346,120 | G/T | — | uncertain significance |
| rs1189106159 | 9:116,346,160 | C/T | — | uncertain significance |
| rs2491124929 | 9:116,346,172 | A/G | — | uncertain significance |
| rs138280516 | 9:116,346,195 | A/G | — | uncertain significance |
| rs745392904 | 9:116,346,201 | G/A | — | uncertain significance |
| rs369700863 | 9:116,346,220 | C/G | — | uncertain significance |
| rs139416272 | 9:116,346,231 | C/T | — | conflicting classifications of pathogenicity |
| rs368801355 | 9:116,346,255 | G/A | — | uncertain significance |
| rs770271426 | 9:116,346,277 | A/C | — | uncertain significance |
| rs201852541 | 9:116,346,348 | G/A | — | uncertain significance |
| rs774689229 | 9:116,346,363 | G/T | — | uncertain significance |
| rs200205068 | 9:116,346,394 | A/C | — | uncertain significance |
| rs754559526 | 9:116,346,414 | G/A | — | uncertain significance |
| rs753584155 | 9:116,346,460 | A/G | — | uncertain significance |
| rs767121295 | 9:116,346,492 | C/A | — | uncertain significance |
| rs144871904 | 9:116,346,499 | C/T | — | uncertain significance |
| rs1588290062 | 9:116,346,501 | C/G | — | uncertain significance |
| rs140611815 | 9:116,346,504 | C/T | — | uncertain significance |
| rs1342908388 | 9:116,346,507 | C/T | — | uncertain significance |
| rs79299242 | 9:116,346,515 | G/A | — | benign |
| rs200934322 | 9:116,346,568 | A/G | — | uncertain significance |
| rs376044741 | 9:116,346,586 | C/T | — | uncertain significance |
| rs148385134 | 9:116,346,607 | C/T | — | uncertain significance |
| rs529868549 | 9:116,346,633 | A/T | — | uncertain significance |
| rs137990160 | 9:116,346,651 | G/A | — | uncertain significance |
| rs147458690 | 9:116,346,704 | G/T | — | uncertain significance |
| rs775648631 | 9:116,353,615 | G/A | — | uncertain significance |
| rs748834164 | 9:116,353,674 | A/G | — | uncertain significance |
| rs753817829 | 9:116,356,793 | A/C | — | uncertain significance |
| rs778725884 | 9:116,357,216 | C/T | — | uncertain significance |
| rs776998917 | 9:116,357,230 | G/A | — | uncertain significance |
| rs1835684108 | 9:116,357,240 | A/T | — | uncertain significance |
| rs758031076 | 9:116,357,899 | G/A | — | uncertain significance |
| rs150045948 | 9:116,357,909 | G/T | — | uncertain significance |
| rs2491193049 | 9:116,358,023 | T/C | — | uncertain significance |
| rs144334750 | 9:116,358,026 | C/T | — | uncertain significance |
| rs764386791 | 9:116,358,039 | C/G | — | uncertain significance |
| rs779938234 | 9:116,359,069 | C/T | — | uncertain significance |
| rs140250676 | 9:116,359,178 | G/A | — | uncertain significance |
| rs768358797 | 9:116,359,226 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.