RIC1

RIC1 partner of RAB6A GEF complex

Summary

Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including positive regulation of GTPase activity; regulation of extracellular matrix constituent secretion; and retrograde transport, endosome to Golgi. Located in cytosol and membrane. Part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants114 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs1817603568	9:5,629,380	A/T	—	uncertain significance
rs191254373	9:5,642,650	A/G	intron variant	—
rs769270863	9:5,656,614	C/G	—	uncertain significance
rs761895871	9:5,656,625	T/C	—	uncertain significance
rs112378773	9:5,680,988	G/A	—	—
rs750877398	9:5,689,980	T/A	—	uncertain significance
rs375748389	9:5,690,026	C/G	—	uncertain significance
rs201052520	9:5,713,908	A/C	—	uncertain significance
rs975910614	9:5,713,968	G/A	—	uncertain significance
rs10758700	9:5,720,172	C/G	—	benign
rs2537450466	9:5,720,268	G/A	—	uncertain significance
rs2537450684	9:5,720,311	G/T	—	likely benign
rs149713037	9:5,720,635	C/T	—	uncertain significance
rs141426151	9:5,720,648	C/T	—	likely benign
rs747338191	9:5,720,698	A/G	—	uncertain significance
rs368039428	9:5,720,734	G/A	—	uncertain significance
rs10975266	9:5,731,178	C/T	—	—
rs762311454	9:5,732,416	T/A	—	uncertain significance
rs148933727	9:5,732,439	G/A	—	uncertain significance
rs143696029	9:5,732,455	G/C	—	uncertain significance
rs7850299	9:5,732,483	T/C	—	benign
rs2537538896	9:5,738,503	C/G	—	uncertain significance
rs75782093	9:5,742,888	A/G	—	benign
rs375672479	9:5,742,948	C/T	—	likely benign
rs371214803	9:5,742,955	C/G	—	uncertain significance
rs750573725	9:5,743,693	A/G	—	likely benign
rs372706997	9:5,745,970	G/A	—	uncertain significance
rs777279235	9:5,745,983	A/C	—	uncertain significance
rs1348440053	9:5,745,989	C/T	—	uncertain significance
rs199560727	9:5,746,003	G/C	—	conflicting classifications of pathogenicity
rs138987836	9:5,746,010	G/T	—	likely benign
rs766522043	9:5,746,042	T/C	—	uncertain significance
rs201153081	9:5,747,304	T/C	—	likely benign
rs145900077	9:5,747,328	G/C	—	uncertain significance
rs771811202	9:5,747,338	C/T	—	uncertain significance
rs143886234	9:5,747,381	C/G	—	likely benign
rs41280731	9:5,747,390	C/A	—	benign
rs147633178	9:5,747,409	T/C	—	benign
rs142276955	9:5,747,418	T/G	—	likely benign
rs147403256	9:5,747,420	G/A	—	uncertain significance
rs976946223	9:5,747,434	T/A	—	uncertain significance
rs777721368	9:5,747,469	C/G	—	uncertain significance
rs771479300	9:5,747,498	T/C	—	uncertain significance
rs576723207	9:5,753,220	G/C	—	uncertain significance
rs1426435477	9:5,753,555	T/C	—	uncertain significance
rs753689510	9:5,753,593	G/A	—	uncertain significance
rs192475946	9:5,754,894	C/A	—	benign
rs544522535	9:5,756,257	C/T	—	uncertain significance
rs763308771	9:5,756,324	G/C	—	uncertain significance
rs200919699	9:5,756,327	C/G	—	likely benign
rs753403564	9:5,756,369	A/G	—	uncertain significance
rs201667482	9:5,757,337	A/G	—	likely benign
rs770460042	9:5,757,362	C/T	—	uncertain significance
rs149164201	9:5,757,363	G/A	—	uncertain significance
rs534899887	9:5,757,386	G/A	—	uncertain significance
rs1047047700	9:5,757,391	A/G	—	likely benign
rs1360718282	9:5,757,428	A/G	—	uncertain significance
rs1543526	9:5,762,533	A/C	—	benign
rs2131093433	9:5,762,595	C/T	—	uncertain significance
rs547159481	9:5,762,616	C/A	—	uncertain significance
rs781586852	9:5,762,621	C/G	—	uncertain significance
rs756524031	9:5,762,623	G/A	—	uncertain significance
rs1286665062	9:5,763,299	C/T	—	uncertain significance
rs993347581	9:5,763,331	C/T	—	likely benign
rs1826465235	9:5,763,360	C/T	—	likely pathogenic
rs753125878	9:5,763,368	G/C	—	uncertain significance
rs778021299	9:5,763,451	A/C	—	uncertain significance
rs149258225	9:5,763,502	G/T	—	uncertain significance
rs143659237	9:5,765,499	G/A	—	uncertain significance
rs778185190	9:5,765,526	T/C	—	uncertain significance
rs762264704	9:5,765,732	A/G	—	uncertain significance
rs1370654973	9:5,769,008	T/C	—	uncertain significance
rs61744825	9:5,769,034	C/T	—	uncertain significance
rs1172120855	9:5,769,035	G/A	—	uncertain significance
rs376971218	9:5,769,038	G/A	—	uncertain significance
rs61744828	9:5,769,043	T/C	—	likely benign
rs2537730656	9:5,769,104	T/G	—	uncertain significance
rs773711235	9:5,769,115	T/C	—	uncertain significance
rs767350707	9:5,769,126	T/C	—	likely benign
rs143393991	9:5,769,140	G/C	—	uncertain significance
rs1165178428	9:5,769,179	A/G	—	uncertain significance
rs148185224	9:5,769,209	C/A	—	uncertain significance
rs768409237	9:5,769,212	C/G	—	uncertain significance
rs766996809	9:5,769,237	A/C	—	uncertain significance
rs144924840	9:5,769,326	A/G	—	likely benign
rs201165896	9:5,770,116	G/C	—	uncertain significance
rs911879650	9:5,770,122	C/A	—	uncertain significance
rs975073169	9:5,770,195	G/A	—	uncertain significance
rs1370169653	9:5,770,236	C/T	—	uncertain significance
rs1827116588	9:5,770,244	G/C	—	uncertain significance
rs143568220	9:5,770,254	T/G	—	uncertain significance
rs147192288	9:5,770,273	A/G	—	likely benign
rs778574444	9:5,772,572	T/G	—	uncertain significance
rs758435306	9:5,772,598	G/C	—	uncertain significance
rs2537753714	9:5,772,657	C/T	—	uncertain significance
rs772444753	9:5,772,711	A/T	—	uncertain significance
rs763515150	9:5,772,741	G/C	—	conflicting classifications of pathogenicity
rs770223963	9:5,772,955	T/G	—	uncertain significance
rs773889558	9:5,772,971	A/G	—	likely benign
rs139608846	9:5,772,978	A/G	—	uncertain significance

Showing 100 of 114 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.