RNASE4
ribonuclease A family member 4
Summary
The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in four transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2013]
Known Variants9 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs3748338 | 14:21,167,576 | A/G | coding sequence variant | — |
| rs771952196 | 14:21,167,634 | G/C | — | uncertain significance |
| rs143247343 | 14:21,167,642 | C/T | coding sequence variant | — |
| rs532574894 | 14:21,167,736 | G/A | — | uncertain significance |
| rs771543461 | 14:21,167,774 | C/G | — | uncertain significance |
| rs1335186121 | 14:21,167,860 | G/T | — | uncertain significance |
| rs2502175244 | 14:21,167,864 | A/G | — | uncertain significance |
| rs570657053 | 14:21,167,919 | G/A | — | uncertain significance |
| rs754559305 | 14:21,167,961 | A/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.