ROBO1
roundabout guidance receptor 1
Summary
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Known Variants422 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1250596351 | 3:78,648,069 | T/A | — | uncertain significance |
| rs374513320 | 3:78,648,090 | C/T | — | likely benign |
| rs747286399 | 3:78,649,252 | A/T | — | likely benign |
| rs535963172 | 3:78,649,269 | T/A | — | uncertain significance |
| rs201046832 | 3:78,649,293 | T/A | — | uncertain significance |
| rs753403387 | 3:78,649,331 | T/C | — | uncertain significance |
| rs1426093876 | 3:78,649,358 | G/T | — | uncertain significance |
| rs1402585434 | 3:78,649,369 | G/A | — | uncertain significance |
| rs377726206 | 3:78,649,377 | T/C | — | likely benign |
| rs1703089925 | 3:78,649,381 | G/C | — | likely pathogenic |
| rs369936880 | 3:78,649,385 | T/C | — | uncertain significance |
| rs143961156 | 3:78,649,401 | G/A | — | likely benign |
| rs748131500 | 3:78,649,404 | A/C | — | likely benign |
| rs1703096607 | 3:78,649,453 | A/G | — | uncertain significance |
| rs753226863 | 3:78,649,456 | T/G | — | uncertain significance |
| rs115569493 | 3:78,655,877 | G/A | — | likely benign |
| rs368157942 | 3:78,655,879 | G/C | — | uncertain significance |
| rs996377836 | 3:78,655,906 | G/A | — | uncertain significance |
| rs767818822 | 3:78,655,908 | T/A | — | likely benign |
| rs35148826 | 3:78,655,923 | T/G | — | benign |
| rs1383050067 | 3:78,655,933 | T/C | — | uncertain significance |
| rs199657294 | 3:78,655,944 | T/G | — | uncertain significance |
| rs775078217 | 3:78,655,950 | G/A | — | likely benign |
| rs879661285 | 3:78,655,959 | C/T | — | likely benign |
| rs1222854966 | 3:78,655,964 | C/T | — | uncertain significance |
| rs768335666 | 3:78,655,966 | T/C | — | uncertain significance |
| rs2471637568 | 3:78,655,973 | C/T | — | uncertain significance |
| rs373644190 | 3:78,655,975 | C/T | — | uncertain significance |
| rs367626947 | 3:78,655,977 | G/A | — | likely benign |
| rs760892507 | 3:78,655,996 | C/T | — | uncertain significance |
| rs1392934228 | 3:78,656,009 | C/T | — | uncertain significance |
| rs757166797 | 3:78,656,014 | C/A | — | uncertain significance |
| rs1703490700 | 3:78,656,015 | T/C | — | uncertain significance |
| rs192249778 | 3:78,656,017 | C/T | — | likely benign |
| rs369610856 | 3:78,656,019 | A/G | — | benign |
| rs756036592 | 3:78,656,021 | C/T | — | uncertain significance |
| rs779835303 | 3:78,656,026 | A/G | — | uncertain significance |
| rs36055689 | 3:78,656,028 | T/G | — | benign |
| rs1248440913 | 3:78,656,037 | C/T | — | likely benign |
| rs1175978892 | 3:78,656,061 | T/G | — | likely benign |
| rs199958211 | 3:78,656,062 | G/A | — | conflicting classifications of pathogenicity |
| rs369808629 | 3:78,656,079 | T/C | — | likely benign |
| rs776804009 | 3:78,656,087 | T/C | — | uncertain significance |
| rs1202297676 | 3:78,656,107 | A/G | — | uncertain significance |
| rs182523991 | 3:78,656,114 | G/A | — | likely benign |
| rs1181501831 | 3:78,656,117 | G/A | — | pathogenic |
| rs780037540 | 3:78,656,133 | C/T | — | likely benign |
| rs771679178 | 3:78,656,142 | G/A | — | likely benign |
| rs1575764347 | 3:78,656,143 | G/C | — | uncertain significance |
| rs1324163287 | 3:78,656,162 | C/T | — | uncertain significance |
| rs771242891 | 3:78,656,163 | A/G | — | likely benign |
| rs1265012079 | 3:78,656,165 | G/C | — | uncertain significance |
| rs372369623 | 3:78,656,169 | C/T | — | likely benign |
| rs1703999102 | 3:78,663,779 | T/A | — | likely benign |
| rs374176620 | 3:78,663,781 | C/T | — | likely benign |
| rs959390539 | 3:78,663,782 | G/A | — | likely benign |
| rs573160338 | 3:78,663,818 | C/T | — | uncertain significance |
| rs370824603 | 3:78,663,819 | G/A | — | uncertain significance |
| rs768938856 | 3:78,663,855 | G/T | — | conflicting classifications of pathogenicity |
| rs776678244 | 3:78,663,869 | A/G | — | uncertain significance |
| rs200590399 | 3:78,663,873 | C/A | — | likely benign |
| rs775367708 | 3:78,663,874 | G/A | — | likely benign |
| rs2471689656 | 3:78,663,875 | G/T | — | uncertain significance |
| rs370200985 | 3:78,663,876 | C/T | — | uncertain significance |
| rs2471689960 | 3:78,663,893 | T/C | — | uncertain significance |
| rs367940062 | 3:78,663,903 | C/T | — | conflicting classifications of pathogenicity |
| rs369600570 | 3:78,663,904 | G/A | — | likely benign |
| rs538506408 | 3:78,663,922 | G/C | — | conflicting classifications of pathogenicity |
| rs558087386 | 3:78,663,931 | C/T | — | likely benign |
| rs775353991 | 3:78,663,932 | G/A | — | uncertain significance |
| rs181957931 | 3:78,663,947 | C/T | — | benign |
| rs4443127 | 3:78,663,949 | A/G | — | benign |
| rs1027832 | 3:78,663,956 | A/G | — | benign |
| rs754360968 | 3:78,663,961 | A/G | — | likely benign |
| rs9839790 | 3:78,666,765 | C/T | — | benign |
| rs778040289 | 3:78,666,808 | C/A | — | uncertain significance |
| rs778615818 | 3:78,666,835 | G/A | — | uncertain significance |
| rs771914948 | 3:78,666,838 | G/A | — | uncertain significance |
| rs754058534 | 3:78,666,871 | G/T | — | uncertain significance |
| rs764402303 | 3:78,666,884 | C/T | — | uncertain significance |
| rs531340562 | 3:78,666,885 | G/T | — | uncertain significance |
| rs2107394417 | 3:78,666,886 | T/G | — | uncertain significance |
| rs777460645 | 3:78,666,911 | C/A | — | pathogenic |
| rs536505138 | 3:78,666,912 | G/A | — | likely benign |
| rs770494845 | 3:78,666,930 | C/T | — | likely benign |
| rs368322759 | 3:78,666,936 | G/A | — | likely benign |
| rs1452850665 | 3:78,666,963 | C/G | — | likely benign |
| rs767632726 | 3:78,666,971 | C/A | — | uncertain significance |
| rs2471716874 | 3:78,666,987 | C/A | — | likely benign |
| rs567571169 | 3:78,666,999 | G/A | — | likely benign |
| rs1239397709 | 3:78,667,016 | G/A | — | uncertain significance |
| rs920741411 | 3:78,667,017 | C/A | — | likely benign |
| rs2471717353 | 3:78,667,018 | C/G | — | uncertain significance |
| rs1169192243 | 3:78,667,027 | A/C | — | uncertain significance |
| rs369134966 | 3:78,667,061 | T/C | — | uncertain significance |
| rs952617454 | 3:78,667,063 | T/A | — | uncertain significance |
| rs757131519 | 3:78,667,065 | G/A | — | likely benign |
| rs372766609 | 3:78,667,081 | T/C | — | uncertain significance |
| rs2471718652 | 3:78,667,117 | G/C | — | uncertain significance |
| rs766398334 | 3:78,667,118 | G/T | — | uncertain significance |
Showing 100 of 422 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.