ROR1

receptor tyrosine kinase like orphan receptor 1

Summary

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

Known Variants169 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs552545525	1:64,240,065	G/A	—	benign
rs2524164790	1:64,240,097	G/A	—	likely benign
rs2524164825	1:64,240,102	G/T	—	uncertain significance
rs1205371508	1:64,240,104	C/A	—	uncertain significance
rs964935302	1:64,240,111	G/A	—	uncertain significance
rs1173539126	1:64,240,122	C/T	—	uncertain significance
rs1404702316	1:64,240,142	C/T	—	likely benign
rs1644599905	1:64,240,162	G/A	—	uncertain significance
rs941042354	1:64,240,187	G/T	—	likely benign
rs606550	1:64,240,240	C/T	—	benign
rs2819142	1:64,280,779	A/G	intron variant	—
rs10889450	1:64,311,200	A/G	—	—
rs11208305	1:64,315,479	G/C	intron variant	—
rs855833	1:64,357,432	G/A	intron variant	—
rs189963568	1:64,374,449	G/A	intron variant	—
rs189033155	1:64,437,750	A/G	intron variant	—
rs285399	1:64,474,804	C/T	—	benign
rs12091083	1:64,474,921	A/G	—	benign
rs137926239	1:64,474,987	G/A	—	likely benign
rs2524694652	1:64,475,009	C/T	—	uncertain significance
rs371472715	1:64,475,010	C/G	—	uncertain significance
rs2524694779	1:64,475,049	G/A	—	uncertain significance
rs140839680	1:64,475,059	G/T	—	benign
rs201785225	1:64,515,355	G/T	—	benign
rs1772626	1:64,515,379	C/T	—	benign
rs55806972	1:64,515,406	G/A	—	likely benign
rs778558577	1:64,515,410	C/G	—	uncertain significance
rs1318530928	1:64,515,438	A/G	—	uncertain significance
rs769633655	1:64,515,454	A/T	—	likely benign
rs1316582696	1:64,515,456	C/T	—	uncertain significance
rs139072514	1:64,515,468	G/A	—	uncertain significance
rs200186767	1:64,515,493	G/A	—	likely benign
rs773348330	1:64,515,522	G/A	—	uncertain significance
rs2100591296	1:64,515,567	C/T	—	uncertain significance
rs1646821615	1:64,516,363	C/T	—	uncertain significance
rs1646821702	1:64,516,374	A/G	—	likely benign
rs1466132520	1:64,516,375	A/G	—	uncertain significance
rs2524796882	1:64,516,378	C/T	—	uncertain significance
rs571667839	1:64,603,062	G/A	—	uncertain significance
rs2525066022	1:64,603,068	G/T	—	uncertain significance
rs781314810	1:64,603,095	A/G	—	uncertain significance
rs1441887932	1:64,603,114	T/C	—	uncertain significance
rs773146068	1:64,603,122	C/A	—	uncertain significance
rs1171302233	1:64,603,138	A/G	—	uncertain significance
rs150006018	1:64,603,193	A/G	—	likely benign
rs145211481	1:64,603,195	G/T	—	benign
rs3738151	1:64,603,231	G/A	—	benign
rs370267241	1:64,605,796	C/G	—	likely benign
rs762201037	1:64,605,800	A/C	—	uncertain significance
rs767798322	1:64,605,811	C/T	—	likely benign
rs755218833	1:64,605,879	C/T	—	uncertain significance
rs748338604	1:64,605,883	C/T	—	likely benign
rs138122388	1:64,605,886	C/T	—	likely benign
rs761232470	1:64,605,929	G/A	—	uncertain significance
rs1457528615	1:64,605,946	G/A	—	likely benign
rs756017115	1:64,605,995	A/G	—	uncertain significance
rs760907729	1:64,606,050	G/A	—	uncertain significance
rs765400955	1:64,606,062	C/T	—	uncertain significance
rs752773676	1:64,606,063	G/A	—	likely benign
rs1220206919	1:64,606,065	A/G	—	uncertain significance
rs777199806	1:64,608,075	G/A	—	likely benign
rs760104769	1:64,608,081	T/C	—	likely benign
rs189581966	1:64,608,124	G/A	—	uncertain significance
rs141665064	1:64,608,131	C/T	—	likely benign
rs150545478	1:64,608,132	G/A	—	uncertain significance
rs141581176	1:64,608,140	G/C	—	likely benign
rs369927901	1:64,608,142	C/G	—	uncertain significance
rs549660782	1:64,608,154	G/A	—	uncertain significance
rs55753613	1:64,608,167	A/G	—	likely benign
rs2525086478	1:64,608,178	A/G	—	uncertain significance
rs34772283	1:64,608,203	C/T	—	benign
rs147878288	1:64,608,204	G/A	—	uncertain significance
rs141411649	1:64,608,211	G/A	—	uncertain significance
rs2525087147	1:64,608,300	T/A	—	uncertain significance
rs138027299	1:64,608,314	G/A	—	likely benign
rs2762833	1:64,608,329	G/T	—	benign
rs11208364	1:64,608,423	G/A	—	benign
rs11587715	1:64,608,563	A/G	—	benign
rs34903612	1:64,622,376	G/T	—	—
rs4362024	1:64,624,612	G/A	—	benign
rs141647401	1:64,624,683	G/A	—	likely benign
rs1033617119	1:64,624,691	A/G	—	uncertain significance
rs552750946	1:64,624,741	A/G	—	uncertain significance
rs754278490	1:64,624,742	T/C	—	uncertain significance
rs201506341	1:64,624,768	G/A	—	uncertain significance
rs771229553	1:64,624,775	G/A	—	uncertain significance
rs775112425	1:64,624,783	C/G	—	uncertain significance
rs139114952	1:64,624,796	C/T	—	likely benign
rs113606454	1:64,624,797	G/A	—	likely benign
rs186939505	1:64,624,804	G/A	—	uncertain significance
rs753466455	1:64,624,824	C/T	—	likely benign
rs6668545	1:64,624,842	A/G	—	benign
rs777805288	1:64,624,845	G/C	—	conflicting classifications of pathogenicity
rs1649865099	1:64,624,863	A/T	—	likely benign
rs1472818505	1:64,624,865	A/G	—	uncertain significance
rs2525133518	1:64,624,870	C/A	—	uncertain significance
rs374877482	1:64,624,888	G/C	—	likely benign
rs7515787	1:64,625,777	T/C	intron variant	—
rs1650413186	1:64,643,112	G/A	—	uncertain significance
rs781140056	1:64,643,129	C/A	—	uncertain significance

Showing 100 of 169 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.