RPS6KC1

ribosomal protein S6 kinase C1

Summary

Sphingosine kinase catalyzes the formation of sphingosine 1 phosphate, a lipid cellular messenger. The protein encoded by this gene can bind to sphingosine kinase and to phosphatidylinositol 3-phosphate, suggesting a role in sphingosine 1 phophate signaling. The encoded protein can also bind to peroxiredoxin-3 and may help transport it to mitochondria. [provided by RefSeq, Mar 2017]

Known Variants247 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs1357449306	1:213,224,766	G/T	—	uncertain significance
rs2076935869	1:213,224,779	G/A	—	likely benign
rs376722820	1:213,224,788	C/T	—	likely benign
rs763853562	1:213,224,801	G/A	—	uncertain significance
rs761152136	1:213,224,804	C/A	—	uncertain significance
rs765345008	1:213,224,813	C/T	—	uncertain significance
rs368815923	1:213,224,817	C/T	—	conflicting classifications of pathogenicity
rs777998280	1:213,224,822	G/C	—	uncertain significance
rs781008492	1:213,224,833	A/G	—	likely benign
rs748753687	1:213,224,859	C/G	—	likely benign
rs113940805	1:213,224,860	C/T	—	benign
rs79466500	1:213,244,330	A/C	—	benign
rs377535571	1:213,244,345	T/C	—	uncertain significance
rs2545540144	1:213,244,363	A/G	—	uncertain significance
rs56087470	1:213,244,366	C/A	—	likely benign
rs775834541	1:213,244,379	A/G	—	uncertain significance
rs763495217	1:213,244,394	T/C	—	likely benign
rs1470557039	1:213,251,032	C/G	—	likely benign
rs2545630752	1:213,251,040	A/C	—	likely benign
rs774349575	1:213,251,060	G/A	—	uncertain significance
rs985461969	1:213,251,086	C/T	—	likely benign
rs2545631956	1:213,251,100	C/T	—	likely benign
rs754894764	1:213,251,110	T/C	—	uncertain significance
rs774844476	1:213,251,164	T/C	—	uncertain significance
rs1203151155	1:213,277,794	A/G	—	uncertain significance
rs763503004	1:213,277,797	G/T	—	likely benign
rs56056039	1:213,277,818	C/A	—	benign
rs1178486862	1:213,277,883	A/C	—	uncertain significance
rs750046943	1:213,277,910	A/G	—	uncertain significance
rs755832407	1:213,277,918	T/C	—	likely benign
rs1456453340	1:213,277,919	A/T	—	likely benign
rs534633318	1:213,290,647	T/G	—	likely benign
rs2546187138	1:213,290,650	T/C	—	likely benign
rs763607331	1:213,290,673	T/G	—	uncertain significance
rs1191028149	1:213,290,689	A/G	—	uncertain significance
rs2148892938	1:213,290,693	G/A	—	uncertain significance
rs577745586	1:213,290,709	C/G	—	likely benign
rs761726809	1:213,290,718	C/T	—	likely benign
rs772666453	1:213,290,723	T/C	—	uncertain significance
rs768174092	1:213,290,747	C/T	—	uncertain significance
rs2148992723	1:213,302,866	C/G	—	likely benign
rs535231866	1:213,302,903	C/T	—	uncertain significance
rs553554592	1:213,302,914	G/T	—	uncertain significance
rs200064577	1:213,302,916	T/G	—	uncertain significance
rs367564641	1:213,302,933	A/T	—	uncertain significance
rs775263280	1:213,302,976	T/C	—	likely benign
rs372834454	1:213,302,980	C/T	—	uncertain significance
rs773772139	1:213,302,984	A/G	—	likely benign
rs766825388	1:213,302,993	C/T	—	uncertain significance
rs141240814	1:213,303,007	C/G	—	benign
rs139296657	1:213,303,019	G/T	—	benign
rs751357136	1:213,303,023	C/T	—	uncertain significance
rs199560994	1:213,303,053	A/T	—	uncertain significance
rs768437981	1:213,303,055	C/T	—	uncertain significance
rs755598192	1:213,303,064	C/T	—	uncertain significance
rs372361416	1:213,303,076	C/T	—	uncertain significance
rs376958657	1:213,303,092	C/T	—	uncertain significance
rs2546372998	1:213,303,098	T/G	—	uncertain significance
rs746298886	1:213,303,135	A/C	—	uncertain significance
rs150727119	1:213,303,165	A/C	—	likely benign
rs573792172	1:213,303,168	C/T	—	likely benign
rs147945661	1:213,303,178	G/A	—	likely benign
rs1330809213	1:213,303,204	A/C	—	likely benign
rs139986699	1:213,303,250	T/C	—	benign
rs752252959	1:213,341,185	A/G	—	likely benign
rs757944948	1:213,341,186	G/C	—	likely benign
rs200774550	1:213,341,190	T/C	—	benign
rs368914061	1:213,341,215	A/G	—	uncertain significance
rs148984854	1:213,341,218	C/T	—	uncertain significance
rs2546858840	1:213,341,243	C/T	—	uncertain significance
rs1014878313	1:213,341,312	C/T	—	uncertain significance
rs2148179865	1:213,341,313	T/C	—	likely benign
rs56369827	1:213,349,747	T/C	—	benign
rs755350002	1:213,349,748	A/C	—	likely benign
rs2546945042	1:213,349,776	A/G	—	uncertain significance
rs373867090	1:213,349,781	A/G	—	likely benign
rs367794519	1:213,349,782	A/C	—	likely benign
rs1198996790	1:213,349,788	C/T	—	uncertain significance
rs144315266	1:213,349,793	C/T	—	benign
rs1371867012	1:213,349,797	G/A	—	uncertain significance
rs2546945632	1:213,349,813	G/A	—	uncertain significance
rs202123122	1:213,349,826	G/C	—	likely benign
rs2546946291	1:213,349,842	C/T	—	likely benign
rs2546946471	1:213,349,850	T/A	—	likely benign
rs768535807	1:213,403,824	C/T	—	likely benign
rs201214518	1:213,403,829	C/T	—	benign
rs2094068897	1:213,403,850	T/C	—	uncertain significance
rs765974995	1:213,403,853	T/C	—	uncertain significance
rs534298090	1:213,403,859	C/G	—	uncertain significance
rs2547504311	1:213,403,878	C/G	—	uncertain significance
rs759327575	1:213,405,455	T/C	—	likely benign
rs1348618234	1:213,405,460	T/C	—	likely benign
rs762345458	1:213,405,462	T/A	—	likely benign
rs755203550	1:213,405,497	A/G	—	uncertain significance
rs2547521809	1:213,405,555	C/A	—	likely benign
rs1284210994	1:213,405,565	G/A	—	uncertain significance
rs772539262	1:213,405,582	G/A	—	likely benign
rs116671995	1:213,405,593	C/T	—	likely benign
rs187492406	1:213,405,606	T/G	—	benign
rs765462916	1:213,405,617	T/C	—	likely benign

Showing 100 of 247 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.