RSAD2
radical S-adenosyl methionine domain containing 2
Summary
The protein encoded by this gene is an interferon-inducible antiviral protein that belongs to the S-adenosyl-L-methionine (SAM) superfamily of enzymes. The protein plays a role in cellular antiviral response and innate immune signaling. Antiviral effects result from inhibition of viral RNA replication, interference in the secretory pathway, binding to viral proteins and dysregulation of cellular lipid metabolism. The protein has been found to inhibit both DNA and RNA viruses, including influenza virus, human immunodeficiency virus (HIV-1) and Zika virus. [provided by RefSeq, Sep 2020]
Known Variants26 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs75460609 | 2:7,017,788 | G/A | regulatory region variant | — |
| rs35784105 | 2:7,017,943 | T/C | — | benign |
| rs2305256 | 2:7,018,021 | G/A | — | benign |
| rs17851586 | 2:7,018,056 | T/G | — | benign |
| rs2527812099 | 2:7,018,158 | A/G | — | uncertain significance |
| rs751694276 | 2:7,018,173 | G/A | — | uncertain significance |
| rs201282882 | 2:7,023,507 | G/C | — | uncertain significance |
| rs116498125 | 2:7,023,575 | G/A | — | benign |
| rs369027364 | 2:7,027,069 | A/G | — | uncertain significance |
| rs373866214 | 2:7,027,078 | A/G | — | uncertain significance |
| rs1040483187 | 2:7,027,087 | C/T | — | uncertain significance |
| rs554141538 | 2:7,027,089 | A/G | — | likely benign |
| rs781571900 | 2:7,027,129 | T/C | — | uncertain significance |
| rs1663535417 | 2:7,027,160 | G/A | — | likely benign |
| rs769334243 | 2:7,027,183 | G/A | — | uncertain significance |
| rs140690041 | 2:7,027,206 | G/A | — | uncertain significance |
| rs143741204 | 2:7,027,268 | C/G | — | uncertain significance |
| rs769680787 | 2:7,027,281 | C/T | — | uncertain significance |
| rs189344406 | 2:7,027,288 | G/A | missense variant | — |
| rs1316561135 | 2:7,030,337 | A/T | — | uncertain significance |
| rs201649824 | 2:7,030,353 | C/T | — | uncertain significance |
| rs758663261 | 2:7,030,386 | A/G | — | uncertain significance |
| rs1444911500 | 2:7,030,403 | T/C | — | uncertain significance |
| rs16865717 | 2:7,032,618 | T/A | — | — |
| rs1663762557 | 2:7,035,946 | C/T | — | uncertain significance |
| rs772284239 | 2:7,036,038 | A/G | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.