RXRA
retinoid X receptor alpha
Summary
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
Known Variants45 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1834915264 | 9:137,218,506 | G/A | — | uncertain significance |
| rs881658 | 9:137,229,855 | C/T | intron variant | — |
| rs881657 | 9:137,230,016 | A/T | — | — |
| rs544749498 | 9:137,239,573 | C/T | — | — |
| rs11185659 | 9:137,243,383 | C/A | — | — |
| rs7864987 | 9:137,248,166 | T/C | regulatory region variant | — |
| rs11185660 | 9:137,259,992 | T/A | — | — |
| rs11185662 | 9:137,262,119 | T/C | regulatory region variant | — |
| rs10881583 | 9:137,267,439 | T/C | regulatory region variant | — |
| rs28970773 | 9:137,267,783 | T/A | — | — |
| rs34192449 | 9:137,272,502 | A/G | regulatory region variant | — |
| rs12004589 | 9:137,290,725 | G/A | — | — |
| rs1805337 | 9:137,293,572 | C/T | — | likely benign |
| rs200082299 | 9:137,293,581 | G/A | — | likely benign |
| rs1805352 | 9:137,299,949 | C/A | intron variant | — |
| rs748518062 | 9:137,300,926 | C/T | — | uncertain significance |
| rs778077188 | 9:137,300,948 | T/C | — | uncertain significance |
| rs3132297 | 9:137,301,866 | A/G | intron variant | — |
| rs3132296 | 9:137,302,631 | C/T | intron variant | — |
| rs3118529 | 9:137,304,915 | C/T | intron variant | — |
| rs3118536 | 9:137,308,462 | A/C | intron variant | — |
| rs1348109062 | 9:137,309,024 | C/T | — | uncertain significance |
| rs146295223 | 9:137,309,041 | C/A | — | uncertain significance |
| rs2490794618 | 9:137,309,054 | G/C | — | uncertain significance |
| rs1588299621 | 9:137,309,064 | G/A | — | likely pathogenic |
| rs781281765 | 9:137,309,067 | G/A | — | uncertain significance |
| rs986185258 | 9:137,309,157 | G/C | — | uncertain significance |
| rs7861779 | 9:137,309,461 | C/T | intron variant | — |
| rs4240705 | 9:137,311,400 | G/C | — | — |
| rs35362553 | 9:137,314,943 | C/T | regulatory region variant | — |
| rs3118570 | 9:137,320,855 | G/C | — | — |
| rs1536475 | 9:137,321,156 | A/T | — | — |
| rs3132293 | 9:137,325,822 | T/A | — | — |
| rs753474465 | 9:137,325,984 | C/T | — | uncertain significance |
| rs6413514 | 9:137,328,175 | T/C | intron variant | — |
| rs1057519958 | 9:137,328,351 | C/T | missense variant | — |
| rs1390461687 | 9:137,328,433 | G/A | — | uncertain significance |
| rs1468244890 | 9:137,328,440 | G/A | — | uncertain significance |
| rs1306245171 | 9:137,328,441 | C/T | — | uncertain significance |
| rs2490844051 | 9:137,328,446 | C/T | — | uncertain significance |
| rs61751480 | 9:137,328,466 | C/T | 3 prime UTR variant | — |
| rs4240711 | 9:137,329,306 | G/A | downstream gene variant | — |
| rs4842194 | 9:137,330,560 | C/T | regulatory region variant | — |
| rs1045570 | 9:137,332,311 | T/A | — | — |
| rs3132291 | 9:137,332,918 | G/T | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.