RXRB
retinoid X receptor beta
Summary
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Known Variants27 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs775312696 | 6:33,162,757 | G/C | — | likely benign |
| rs768482224 | 6:33,162,803 | C/T | — | uncertain significance |
| rs2535687113 | 6:33,163,195 | C/T | — | uncertain significance |
| rs184921826 | 6:33,163,397 | G/A | — | likely benign |
| rs188577937 | 6:33,163,409 | G/A | — | likely benign |
| rs6531 | 6:33,163,451 | A/G | — | benign |
| rs757764298 | 6:33,164,233 | C/T | — | uncertain significance |
| rs201059237 | 6:33,164,249 | C/T | — | likely benign |
| rs776600395 | 6:33,164,330 | C/G | — | uncertain significance |
| rs186232872 | 6:33,165,724 | G/C | — | benign |
| rs2076310 | 6:33,166,034 | A/G | upstream gene variant | — |
| rs61730281 | 6:33,166,101 | G/A | — | benign |
| rs1309700636 | 6:33,166,163 | C/T | — | uncertain significance |
| rs369876854 | 6:33,166,956 | C/T | — | uncertain significance |
| rs781182486 | 6:33,167,004 | G/A | — | uncertain significance |
| rs371739737 | 6:33,167,047 | G/T | — | uncertain significance |
| rs574161638 | 6:33,167,062 | G/T | — | uncertain significance |
| rs201700806 | 6:33,167,119 | G/A | — | likely benign |
| rs2535737510 | 6:33,167,122 | G/A | — | uncertain significance |
| rs2535738510 | 6:33,167,167 | G/A | — | uncertain significance |
| rs748869683 | 6:33,168,058 | C/G | — | uncertain significance |
| rs768449691 | 6:33,168,064 | C/G | — | uncertain significance |
| rs752973611 | 6:33,168,099 | G/C | — | uncertain significance |
| rs1489179402 | 6:33,168,201 | T/C | — | uncertain significance |
| rs754861170 | 6:33,168,228 | A/G | — | uncertain significance |
| rs2150679110 | 6:33,168,535 | T/G | — | likely benign |
| rs113790335 | 6:33,168,716 | G/A | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.