S100A3

S100 calcium binding protein A3

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown. [provided by RefSeq, Jul 2008]

Known Variants14 total

rsidPosition (GRCh37)AllelesClassClinVar
rs5715968921:153,520,175G/Auncertain significance
rs7500718571:153,520,186C/Auncertain significance
rs16656080081:153,520,194G/Cuncertain significance
rs1383557061:153,520,235G/Abenign
rs1162084831:153,520,280G/Clikely benign
rs1483427481:153,520,297T/Cuncertain significance
rs7566962451:153,520,309T/Cuncertain significance
rs795760271:153,520,321G/Cuncertain significance
rs780317811:153,520,513C/Tupstream gene variant
rs563504251:153,520,520T/Cupstream gene variant
rs7629006431:153,520,904C/Tuncertain significance
rs2003559971:153,520,925C/Auncertain significance
rs1939210841:153,520,937C/Auncertain significance
rs7762100521:153,520,939G/Auncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.