S1PR5
sphingosine-1-phosphate receptor 5
Summary
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]
Known Variants31 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs544571964 | 19:10,624,073 | C/A | — | — |
| rs139502994 | 19:10,624,508 | C/T | — | uncertain significance |
| rs140531381 | 19:10,624,510 | G/C | — | likely benign |
| rs769745882 | 19:10,624,615 | C/T | — | uncertain significance |
| rs1182164627 | 19:10,624,693 | G/A | — | likely benign |
| rs560119222 | 19:10,624,704 | G/A | — | likely benign |
| rs149806324 | 19:10,624,765 | A/T | — | benign |
| rs146786075 | 19:10,624,786 | A/G | — | uncertain significance |
| rs763804506 | 19:10,624,858 | C/A | — | uncertain significance |
| rs75861469 | 19:10,624,863 | C/T | — | benign |
| rs764832448 | 19:10,624,868 | C/A | — | uncertain significance |
| rs759168775 | 19:10,624,985 | T/C | — | uncertain significance |
| rs1243463923 | 19:10,625,002 | C/T | — | uncertain significance |
| rs942884799 | 19:10,625,005 | G/A | — | uncertain significance |
| rs1408208100 | 19:10,625,044 | A/C | — | uncertain significance |
| rs372680615 | 19:10,625,057 | G/C | — | uncertain significance |
| rs374944848 | 19:10,625,090 | C/G | — | uncertain significance |
| rs34803021 | 19:10,625,121 | G/A | — | benign |
| rs745328786 | 19:10,625,152 | A/G | — | uncertain significance |
| rs1433473685 | 19:10,625,239 | C/A | — | uncertain significance |
| rs1445236954 | 19:10,625,259 | C/T | — | likely benign |
| rs775044143 | 19:10,625,261 | C/T | — | uncertain significance |
| rs35940589 | 19:10,625,265 | C/T | — | likely benign |
| rs760180493 | 19:10,625,303 | T/C | — | uncertain significance |
| rs2512456489 | 19:10,625,410 | A/G | — | uncertain significance |
| rs886690346 | 19:10,625,476 | A/G | — | uncertain significance |
| rs2512456661 | 19:10,625,549 | A/C | — | uncertain significance |
| rs769527790 | 19:10,625,564 | C/A | — | uncertain significance |
| rs560472766 | 19:10,625,620 | C/A | — | uncertain significance |
| rs377292940 | 19:10,625,621 | C/T | — | uncertain significance |
| rs773755164 | 19:10,625,659 | G/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.