SCLY
selenocysteine lyase
Summary
Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008]
Known Variants54 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1287803598 | 2:238,969,690 | G/T | — | uncertain significance |
| rs768491417 | 2:238,969,727 | C/T | — | uncertain significance |
| rs964908969 | 2:238,969,729 | C/G | — | uncertain significance |
| rs771978013 | 2:238,973,058 | G/T | — | uncertain significance |
| rs769529884 | 2:238,973,099 | C/T | — | likely benign |
| rs141888719 | 2:238,976,709 | G/T | — | uncertain significance |
| rs759726342 | 2:238,976,714 | G/A | — | uncertain significance |
| rs138801169 | 2:238,976,721 | A/G | — | uncertain significance |
| rs751440437 | 2:238,976,738 | C/T | — | uncertain significance |
| rs76625747 | 2:238,976,761 | A/G | — | benign |
| rs747462994 | 2:238,976,763 | G/T | — | uncertain significance |
| rs779932782 | 2:238,976,795 | G/A | — | uncertain significance |
| rs150178192 | 2:238,976,802 | C/G | — | uncertain significance |
| rs2474094879 | 2:238,978,064 | G/C | — | uncertain significance |
| rs2469551760 | 2:238,990,364 | C/G | — | uncertain significance |
| rs773962297 | 2:238,990,365 | C/T | — | uncertain significance |
| rs776678006 | 2:238,990,400 | G/A | — | uncertain significance |
| rs146667548 | 2:238,990,448 | C/G | — | uncertain significance |
| rs115220643 | 2:238,990,484 | C/T | — | benign |
| rs774661539 | 2:238,990,701 | A/C | — | uncertain significance |
| rs773584417 | 2:238,990,708 | G/C | — | uncertain significance |
| rs765523812 | 2:238,990,734 | G/A | — | uncertain significance |
| rs367556253 | 2:238,990,761 | G/A | — | likely benign |
| rs752963333 | 2:238,990,797 | C/A | — | uncertain significance |
| rs768478627 | 2:238,990,800 | G/A | — | uncertain significance |
| rs2278743 | 2:238,991,560 | T/A | — | — |
| rs35637307 | 2:238,991,938 | T/C | — | benign |
| rs143511249 | 2:238,991,979 | C/T | — | uncertain significance |
| rs62195997 | 2:238,997,725 | A/G | intron variant | — |
| rs748142420 | 2:238,999,873 | C/T | — | uncertain significance |
| rs199772775 | 2:238,999,875 | A/G | — | uncertain significance |
| rs777079762 | 2:239,002,505 | G/A | — | uncertain significance |
| rs139477296 | 2:239,002,506 | C/G | — | uncertain significance |
| rs753199666 | 2:239,002,526 | T/C | — | uncertain significance |
| rs77553822 | 2:239,002,556 | G/A | — | benign |
| rs755796401 | 2:239,002,559 | C/T | — | uncertain significance |
| rs777117566 | 2:239,003,110 | C/G | — | uncertain significance |
| rs762200127 | 2:239,003,133 | A/C | — | uncertain significance |
| rs374330427 | 2:239,003,145 | C/T | — | uncertain significance |
| rs565261678 | 2:239,005,489 | G/T | — | uncertain significance |
| rs139057106 | 2:239,005,494 | G/C | — | likely benign |
| rs369781333 | 2:239,005,502 | C/T | — | uncertain significance |
| rs558291998 | 2:239,005,637 | C/T | — | — |
| rs13395126 | 2:239,005,760 | A/T | — | — |
| rs11682046 | 2:239,006,650 | T/C | — | — |
| rs775329973 | 2:239,006,845 | C/T | — | uncertain significance |
| rs369357276 | 2:239,006,866 | A/G | — | likely benign |
| rs777801998 | 2:239,006,887 | C/A | — | uncertain significance |
| rs35544137 | 2:239,006,891 | G/A | — | benign |
| rs78475597 | 2:239,006,933 | C/T | — | benign |
| rs751716402 | 2:239,006,934 | G/A | — | uncertain significance |
| rs750203065 | 2:239,006,943 | C/T | — | uncertain significance |
| rs148012854 | 2:239,006,974 | C/T | — | uncertain significance |
| rs62196005 | 2:239,007,130 | A/T | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.