SCN3B

sodium voltage-gated channel beta subunit 3

Summary

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Known Variants200 total

rsidPosition (GRCh37)AllelesClassClinVar
rs76529461711:123,499,919A/G—uncertain significance
rs86730268211:123,502,141C/T—uncertain significance
rs7255219811:123,503,998C/T—benign
rs8001772011:123,504,060G/T—uncertain significance
rs11169082611:123,504,354G/A—benign
rs13952596711:123,504,481C/T—benign
rs105752433411:123,504,499A/T—likely benign
rs114811111:123,504,673C/G—benign
rs19955260111:123,504,813T/G—benign
rs75096946911:123,504,867A/C—uncertain significance
rs121347651611:123,504,868C/T—uncertain significance
rs75891535511:123,504,869C/T—likely benign
rs18634115911:123,504,870G/A—conflicting classifications of pathogenicity
rs249755499011:123,504,871C/T—uncertain significance
rs146144226911:123,504,875G/A—likely benign
rs123990083111:123,504,878C/T—likely benign
rs75526615311:123,504,881C/G—uncertain significance
rs78124497511:123,504,885T/C—uncertain significance
rs249755510411:123,504,891G/A—uncertain significance
rs195570114011:123,504,898T/C—uncertain significance
rs249755518711:123,504,902A/G—likely benign
rs77777682711:123,504,912G/C—uncertain significance
rs140734689511:123,504,915C/G—uncertain significance
rs213723110311:123,504,916T/C—uncertain significance
rs74583064311:123,504,918T/C—likely benign
rs213723113011:123,504,930G/A—likely benign
rs114811011:123,504,959C/G—benign
rs7255214511:123,505,044G/A—likely benign
rs7255214611:123,505,070T/C—likely benign
rs114810911:123,505,099C/T—benign
rs11536569211:123,505,104A/T—likely benign
rs455489911:123,508,688G/T—benign
rs227602211:123,508,764A/G—likely benign
rs227602311:123,508,803G/A—likely benign
rs711225811:123,508,842A/G—benign
rs105752088211:123,508,882C/T—likely benign
rs213723576611:123,508,885T/G—likely benign
rs131405345711:123,508,893C/T—uncertain significance
rs76784351411:123,508,894G/A—uncertain significance
rs37575577011:123,508,895C/T—conflicting classifications of pathogenicity
rs3496416811:123,508,896G/A—likely benign
rs134958498611:123,508,904G/C—uncertain significance
rs57541966411:123,508,908T/C—likely benign
rs195575079011:123,508,910C/T—uncertain significance
rs155511500311:123,508,913C/T—uncertain significance
rs76917383111:123,508,916C/T—uncertain significance
rs74688862011:123,508,917G/A—likely benign
rs78098310711:123,508,937A/T—uncertain significance
rs74777606411:123,508,941A/G—likely benign
rs123208880511:123,508,943A/G—uncertain significance
rs77288599311:123,508,953G/A—likely benign
rs89648618611:123,508,959C/A—likely benign
rs76003468811:123,508,961G/C—uncertain significance
rs100153202811:123,508,989G/A—likely benign
rs75306838111:123,508,992C/T—uncertain significance
rs57125589311:123,508,994T/C—uncertain significance
rs58777755711:123,508,996A/Gmissense variantpathogenic
rs249756236711:123,509,024C/T—uncertain significance
rs213723604711:123,509,032G/C—uncertain significance
rs159134399511:123,509,036A/C—likely benign
rs52784580111:123,509,039G/C—likely benign
rs5665595611:123,509,236G/A—benign
rs7632365811:123,512,957A/G—benign
rs147476562011:123,513,134A/C—likely benign
rs75999696011:123,513,146A/G—likely benign
rs99615254911:123,513,151C/T—conflicting classifications of pathogenicity
rs130143216711:123,513,158C/A—uncertain significance
rs133228524711:123,513,160C/T—uncertain significance
rs127508511:123,513,161G/T—benign
rs54804481911:123,513,163T/C—uncertain significance
rs87925373011:123,513,176G/Cmissense variantpathogenic
rs95492659011:123,513,179C/A—likely benign
rs77080174711:123,513,183C/T—conflicting classifications of pathogenicity
rs36805437511:123,513,184G/A—conflicting classifications of pathogenicity
rs75406516911:123,513,185C/T—likely benign
rs76196405511:123,513,186G/A—uncertain significance
rs76525461111:123,513,188C/T—likely benign
rs75047644411:123,513,189G/A—uncertain significance
rs144538434511:123,513,192T/C—uncertain significance
rs75491235911:123,513,195A/G—uncertain significance
rs195580396011:123,513,200G/T—likely benign
rs75259328711:123,513,203C/A—likely benign
rs75596715111:123,513,204C/T—uncertain significance
rs37155819611:123,513,205G/A—uncertain significance
rs145713892511:123,513,207T/C—uncertain significance
rs249757246111:123,513,208G/T—uncertain significance
rs14848474411:123,513,209C/T—likely benign
rs58777755611:123,513,210G/Tmissense variantuncertain significance
rs74536588911:123,513,215A/C—uncertain significance
rs195580439911:123,513,219T/C—uncertain significance
rs20189453711:123,513,228C/T—uncertain significance
rs74745236011:123,513,229G/A—uncertain significance
rs88603888111:123,513,236A/G—likely benign
rs175432167111:123,513,245G/C—uncertain significance
rs195580489011:123,513,258T/A—uncertain significance
rs14261355611:123,513,260G/A—likely benign
rs249757265911:123,513,265G/C—uncertain significance
rs121272940111:123,513,266A/G—likely benign
rs249757267311:123,513,269G/A—likely benign
rs14720561711:123,513,271C/Tmissense variantpathogenic

Showing 100 of 200 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.