SDC2
syndecan 2
Summary
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]
Known Variants12 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs61599409 | 8:97,505,530 | T/A | — | — |
| rs1371881318 | 8:97,506,525 | C/T | — | uncertain significance |
| rs529028826 | 8:97,514,223 | G/A | — | — |
| rs762887653 | 8:97,605,729 | A/G | — | uncertain significance |
| rs370731563 | 8:97,605,736 | T/A | — | uncertain significance |
| rs1042381 | 8:97,614,661 | T/A | — | benign |
| rs377256741 | 8:97,614,683 | T/G | — | uncertain significance |
| rs199845377 | 8:97,614,716 | C/T | — | uncertain significance |
| rs143693366 | 8:97,621,619 | T/C | — | uncertain significance |
| rs781657660 | 8:97,621,642 | C/T | — | uncertain significance |
| rs774751152 | 8:97,621,679 | G/A | — | uncertain significance |
| rs17788084 | 8:97,622,948 | A/T | 3 prime UTR variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.