SDCBP2

syndecan binding protein 2

Summary

The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. [provided by RefSeq, Sep 2011]

Known Variants18 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs368582007	20:1,291,102	A/G	—	uncertain significance
rs2514728712	20:1,291,120	G/A	—	uncertain significance
rs2514730192	20:1,291,456	T/G	—	uncertain significance
rs200343104	20:1,291,496	C/T	—	uncertain significance
rs773190093	20:1,293,004	C/G	—	uncertain significance
rs141582918	20:1,293,039	C/A	—	uncertain significance
rs926792736	20:1,293,066	A/C	—	uncertain significance
rs200177394	20:1,293,130	T/C	—	uncertain significance
rs781260947	20:1,293,142	G/A	—	uncertain significance
rs1401197027	20:1,293,150	G/A	—	uncertain significance
rs1335095958	20:1,293,297	G/A	—	uncertain significance
rs754710456	20:1,293,298	A/C	—	uncertain significance
rs754691102	20:1,293,339	T/C	—	uncertain significance
rs2514735096	20:1,293,376	T/G	—	uncertain significance
rs753344660	20:1,294,094	C/G	—	uncertain significance
rs1266991904	20:1,299,026	A/G	—	uncertain significance
rs373178879	20:1,300,239	G/A	—	uncertain significance
rs184282432	20:1,306,960	C/T	regulatory region variant	—

Gene information from NCBI Gene. Variant classifications from ClinVar.