SEMG2
semenogelin 2
Summary
The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. An antibacterial activity has been found for a antimicrobial peptide isolated from this protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20. [provided by RefSeq, Jan 2015]
Known Variants34 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs142457166 | 20:43,850,059 | C/A | — | uncertain significance |
| rs202123772 | 20:43,850,064 | C/T | — | uncertain significance |
| rs374965635 | 20:43,850,089 | C/G | — | uncertain significance |
| rs1984017193 | 20:43,850,379 | T/A | — | uncertain significance |
| rs148802229 | 20:43,850,391 | C/A | — | uncertain significance |
| rs374489769 | 20:43,850,419 | T/C | — | likely benign |
| rs1428763818 | 20:43,850,479 | A/T | — | uncertain significance |
| rs773132069 | 20:43,850,670 | G/A | — | uncertain significance |
| rs758419957 | 20:43,850,713 | G/A | — | uncertain significance |
| rs374328644 | 20:43,850,772 | T/C | — | uncertain significance |
| rs1383249004 | 20:43,850,782 | G/A | — | uncertain significance |
| rs750588135 | 20:43,850,784 | C/A | — | uncertain significance |
| rs1160721932 | 20:43,850,791 | A/C | — | uncertain significance |
| rs138018319 | 20:43,850,832 | C/T | stop gained | — |
| rs772703748 | 20:43,850,895 | C/T | — | uncertain significance |
| rs144655663 | 20:43,850,896 | G/A | — | uncertain significance |
| rs2515498518 | 20:43,850,974 | T/G | — | uncertain significance |
| rs370416178 | 20:43,850,991 | C/T | — | uncertain significance |
| rs377250457 | 20:43,851,081 | A/G | — | uncertain significance |
| rs140069155 | 20:43,851,147 | C/G | — | uncertain significance |
| rs145586123 | 20:43,851,148 | G/A | — | uncertain significance |
| rs555317796 | 20:43,851,279 | G/T | — | uncertain significance |
| rs765676787 | 20:43,851,417 | A/G | — | uncertain significance |
| rs745591744 | 20:43,851,505 | C/G | — | uncertain significance |
| rs757231503 | 20:43,851,564 | A/G | — | uncertain significance |
| rs756192407 | 20:43,851,726 | A/G | — | uncertain significance |
| rs772776203 | 20:43,851,783 | G/A | — | uncertain significance |
| rs557609531 | 20:43,851,856 | G/A | — | uncertain significance |
| rs367805884 | 20:43,851,871 | G/A | — | uncertain significance |
| rs144216536 | 20:43,851,881 | C/A | — | uncertain significance |
| rs770890895 | 20:43,851,904 | G/A | — | uncertain significance |
| rs546435669 | 20:43,851,943 | T/C | — | uncertain significance |
| rs753995233 | 20:43,851,949 | C/T | — | likely benign |
| rs143330825 | 20:43,851,970 | A/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.