SERPINE2

serpin family E member 2

Summary

This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Known Variants38 total

rsidPosition (GRCh37)AllelesClassClinVar
rs67545612:224,839,696T/A
rs67341002:224,841,995C/Gintron variant
rs7296312:224,844,919C/Gregulatory region variant
rs9752782:224,847,707T/A
rs75834632:224,849,109A/Cintron variant
rs1860947602:224,849,482C/Auncertain significance
rs67487952:224,850,723G/A
rs1858690072:224,854,455G/Aintron variant
rs24694269642:224,856,521A/Cuncertain significance
rs2004327672:224,856,571C/Tuncertain significance
rs14696042052:224,856,585A/Guncertain significance
rs7671995892:224,856,658G/Auncertain significance
rs168654212:224,858,093A/Gintron variant
rs37958792:224,862,821C/Tregulatory region variant
rs124572:224,862,842A/Gsynonymous variant
rs7739663822:224,862,898C/Tuncertain significance
rs16909703622:224,862,936G/Cuncertain significance
rs5494486792:224,862,979C/Tuncertain significance
rs16909752582:224,863,014T/Cuncertain significance
rs7555181422:224,863,021C/Tuncertain significance
rs7475970852:224,863,029T/Cuncertain significance
rs37958772:224,866,177A/Gintron variant
rs11891064602:224,866,365C/Tuncertain significance
rs7608280832:224,866,408G/Alikely benign
rs11691539052:224,866,461T/Clikely benign
rs7510413822:224,866,511A/Guncertain significance
rs7670058972:224,866,517G/Auncertain significance
rs3688962992:224,866,572G/Auncertain significance
rs21184092:224,869,643G/A
rs75837992:224,871,995G/Aintron variant
rs75840562:224,872,383C/A
rs18661522:224,878,079A/C
rs5738298902:224,884,423C/T
rs743632942:224,890,646G/Cregulatory region variant
rs1868698202:224,897,176G/Aintron variant
rs8400882:224,899,844T/A
rs75796462:224,900,696G/Aintron variant
rs8639572:224,900,820C/Tintron variant

Gene information from NCBI Gene. Variant classifications from ClinVar.