SGPL1

sphingosine-1-phosphate lyase 1

Summary

Enables sphinganine-1-phosphate aldolase activity. Involved in apoptotic signaling pathway; fatty acid metabolic process; and sphingolipid metabolic process. Located in endoplasmic reticulum. Implicated in nephrotic syndrome type 14. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants236 total

rsidPosition (GRCh37)AllelesClassClinVar
rs55092822810:72,576,615T/C—likely benign
rs249267309210:72,576,643C/A—likely benign
rs37198144010:72,576,651G/C—likely benign
rs5576302210:72,583,601G/A——
rs11312730510:72,596,921G/Aintron variant—
rs168393510:72,599,167T/Cintron variant—
rs75657393110:72,604,215C/T—likely benign
rs117073413410:72,604,234C/T—uncertain significance
rs18819466510:72,604,246A/G—conflicting classifications of pathogenicity
rs1277033510:72,604,263T/G—benign
rs133318604610:72,604,270C/G—uncertain significance
rs213188501610:72,604,274A/C—likely benign
rs76858964910:72,604,275A/G—uncertain significance
rs129277800010:72,604,289T/C—likely benign
rs76763701410:72,604,334A/G—likely benign
rs119649763510:72,604,336G/A—pathogenic
rs57163611710:72,604,344G/A—uncertain significance
rs75430880110:72,604,346G/T—likely benign
rs37570760010:72,604,355G/A—likely benign
rs37011130710:72,604,367G/A—pathogenic
rs77959640810:72,604,368G/T—pathogenic
rs249273538010:72,604,373T/C—likely benign
rs132645240010:72,604,384T/G—uncertain significance
rs184576433510:72,604,394G/C—uncertain significance
rs184576450010:72,604,407G/C—likely benign
rs37249879010:72,604,415T/C—likely benign
rs11498806910:72,604,487G/A—benign
rs5586013710:72,607,219T/Gintron variant—
rs1159463610:72,610,767A/T—benign
rs14341839610:72,610,911A/G—uncertain significance
rs88641327610:72,610,942G/A—uncertain significance
rs74796104310:72,610,943G/A—likely benign
rs77304237810:72,610,958T/C—likely benign
rs20148584810:72,610,962C/T—uncertain significance
rs113169225310:72,610,968G/A—pathogenic
rs20034319010:72,610,983G/T—likely benign
rs1159699710:72,614,271A/G—benign
rs217115710:72,614,421T/C—benign
rs76876214010:72,614,460T/C—likely benign
rs74917638210:72,614,470A/T—likely benign
rs249275876010:72,614,473C/G—uncertain significance
rs77536851810:72,614,476G/A—likely benign
rs77681206610:72,614,509C/T—likely benign
rs14882997310:72,614,515A/G—likely benign
rs184593787410:72,614,520T/C—uncertain significance
rs1159705010:72,614,524A/G—benign
rs140423463010:72,614,531A/G—uncertain significance
rs75099358010:72,614,536G/T—uncertain significance
rs133130947910:72,614,537T/C—uncertain significance
rs249275921210:72,614,569C/G—uncertain significance
rs249275922210:72,614,570T/C—uncertain significance
rs125465933010:72,614,599G/A—likely benign
rs36764411110:72,614,609A/T—uncertain significance
rs37180186910:72,614,620G/A—likely benign
rs100745418610:72,614,627A/T—likely benign
rs11329017510:72,617,210A/T—benign
rs229784210:72,617,256A/T—benign
rs138301905910:72,617,351G/T—likely benign
rs77861417110:72,617,352A/C—likely benign
rs75035786710:72,617,363C/G—likely benign
rs77774118210:72,617,372C/T—likely benign
rs78119288210:72,617,373G/T—uncertain significance
rs74822967610:72,617,374C/T—uncertain significance
rs184598710010:72,617,401G/C—uncertain significance
rs158946520410:72,617,413G/A—uncertain significance
rs77491887310:72,617,414T/C—likely benign
rs74684027310:72,617,421G/A—uncertain significance
rs56786849810:72,617,424A/G—uncertain significance
rs249276587210:72,617,444G/T—likely benign
rs249276598910:72,617,467G/A—likely benign
rs1082362910:72,618,900C/T—benign
rs11277708310:72,619,033G/A—benign
rs249276967110:72,619,130T/C—likely benign
rs11472698610:72,619,145A/G—likely benign
rs76820909010:72,619,154C/T—likely benign
rs77606337510:72,619,155C/T—uncertain significance
rs76487688310:72,619,175C/T—likely benign
rs77294942710:72,619,185C/T—uncertain significance
rs20153311510:72,619,192T/C—uncertain significance
rs82725510:72,619,205C/T—benign
rs53261967210:72,619,231A/G—uncertain significance
rs118801097410:72,619,238A/T—likely benign
rs55076942610:72,619,247G/A—likely benign
rs213191313810:72,619,262T/G—uncertain significance
rs53676686910:72,619,271G/A—likely benign
rs8033780710:72,619,473G/A—benign
rs4130599910:72,628,054A/G—benign
rs75875541810:72,628,083C/T—likely benign
rs143258443210:72,628,088C/A—likely benign
rs249279115110:72,628,119A/G—likely benign
rs78157034610:72,628,146A/G—likely benign
rs113169225510:72,628,150C/T—pathogenic
rs76925944610:72,628,151G/Amissense variantpathogenic
rs77732759810:72,628,160C/T—uncertain significance
rs126739462610:72,628,169A/C—uncertain significance
rs19103352210:72,628,170G/C—uncertain significance
rs20188020710:72,628,181C/T—uncertain significance
rs55841681110:72,628,185A/G—likely benign
rs98292187410:72,628,207G/A—likely benign
rs75689187510:72,629,530C/T—likely benign

Showing 100 of 236 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.