SGPP1

sphingosine-1-phosphate phosphatase 1

Summary

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009]

Known Variants61 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs1884967771	14:64,152,890	T/C	—	uncertain significance
rs752176842	14:64,152,941	C/T	—	uncertain significance
rs780322844	14:64,152,956	G/A	—	uncertain significance
rs1483138817	14:64,153,037	A/G	—	uncertain significance
rs371248974	14:64,153,083	G/A	—	uncertain significance
rs774125790	14:64,153,152	A/C	—	uncertain significance
rs760448063	14:64,153,188	C/T	—	uncertain significance
rs749330071	14:64,153,236	A/G	—	uncertain significance
rs2549488515	14:64,153,263	T/C	—	uncertain significance
rs374247390	14:64,153,295	T/G	—	uncertain significance
rs139614441	14:64,153,301	T/C	—	uncertain significance
rs55706628	14:64,154,302	G/C	intron variant	—
rs11846081	14:64,154,980	A/G	intron variant	—
rs113338490	14:64,155,426	T/C	intron variant	—
rs118120036	14:64,160,949	G/A	intron variant	—
rs73265705	14:64,163,037	T/C	intron variant	—
rs111406613	14:64,163,561	G/A	intron variant	—
rs17101371	14:64,165,826	C/G	intron variant	—
rs537173728	14:64,166,706	G/C	—	—
rs73265719	14:64,169,993	A/G	intron variant	—
rs7157815	14:64,170,741	C/T	intron variant	—
rs113431361	14:64,170,750	G/A	intron variant	—
rs113023275	14:64,172,351	G/A	regulatory region variant	—
rs11158504	14:64,173,950	C/T	regulatory region variant	—
rs11158506	14:64,174,158	C/G	regulatory region variant	—
rs11849082	14:64,175,791	A/C	intron variant	—
rs7156219	14:64,177,127	C/T	intron variant	—
rs113406905	14:64,177,930	C/A	—	—
rs148590087	14:64,183,701	G/A	intron variant	—
rs111774795	14:64,184,735	A/G	regulatory region variant	—
rs73265745	14:64,185,301	A/G	intron variant	—
rs7156594	14:64,187,953	G/A	intron variant	—
rs189870469	14:64,190,869	T/A	intron variant	—
rs182319497	14:64,190,870	G/T	intron variant	—
rs11850599	14:64,192,085	C/A	regulatory region variant	—
rs2031940	14:64,192,304	G/A	regulatory region variant	—
rs56015314	14:64,192,404	C/T	intron variant	—
rs370691997	14:64,193,992	T/C	—	uncertain significance
rs2549497989	14:64,194,076	A/G	—	uncertain significance
rs1595076271	14:64,194,154	A/G	—	uncertain significance
rs536293796	14:64,194,194	G/C	—	likely benign
rs1885909998	14:64,194,228	G/C	—	uncertain significance
rs749679862	14:64,194,261	G/C	—	uncertain significance
rs1885911469	14:64,194,274	C/T	—	likely benign
rs2549498193	14:64,194,298	C/T	—	likely benign
rs764028107	14:64,194,299	G/A	—	uncertain significance
rs367745142	14:64,194,310	C/T	—	uncertain significance
rs150004807	14:64,194,336	G/A	—	likely benign
rs761781978	14:64,194,344	C/T	—	uncertain significance
rs1432111212	14:64,194,358	G/T	—	uncertain significance
rs767174302	14:64,194,359	G/A	—	uncertain significance
rs746223290	14:64,194,373	A/G	—	uncertain significance
rs1023547121	14:64,194,410	C/A	—	uncertain significance
rs1265379919	14:64,194,425	G/C	—	uncertain significance
rs8006901	14:64,194,459	A/G	synonymous variant	—
rs759309325	14:64,194,551	C/G	—	uncertain significance
rs78629217	14:64,195,005	C/G	regulatory region variant	—
rs113375480	14:64,196,135	C/T	upstream gene variant	—
rs150113282	14:64,196,193	G/A	upstream gene variant	—
rs56280069	14:64,196,337	C/T	upstream gene variant	—
rs56388534	14:64,196,498	C/A	—	—

Gene information from NCBI Gene. Variant classifications from ClinVar.