SGSM2
small G protein signaling modulator 2
Summary
The protein encoded by this gene is a GTPase activator with activity towards RAB32 and RAB33B, which are regulators of membrane trafficking. The encoded protein inactivates RAB32 and can bind RAB9A-GTP, a protein required for RAB32 activation. [provided by RefSeq, Oct 2016]
Known Variants76 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1164459244 | 17:2,240,998 | G/A | — | uncertain significance |
| rs144978219 | 17:2,241,009 | A/C | — | uncertain significance |
| rs1440021075 | 17:2,246,854 | G/A | — | uncertain significance |
| rs4790333 | 17:2,262,703 | C/A | — | — |
| rs778161270 | 17:2,264,972 | G/A | — | uncertain significance |
| rs200865639 | 17:2,264,973 | C/T | — | uncertain significance |
| rs61745009 | 17:2,264,987 | C/T | — | uncertain significance |
| rs141118030 | 17:2,264,988 | G/A | — | uncertain significance |
| rs776451471 | 17:2,265,005 | G/A | — | uncertain significance |
| rs61733095 | 17:2,265,033 | G/C | — | benign |
| rs372911434 | 17:2,265,036 | C/T | — | uncertain significance |
| rs975294805 | 17:2,265,063 | T/C | — | uncertain significance |
| rs144055505 | 17:2,265,408 | C/T | — | uncertain significance |
| rs777229356 | 17:2,265,423 | A/C | — | uncertain significance |
| rs370406580 | 17:2,265,536 | G/T | — | uncertain significance |
| rs767629912 | 17:2,266,319 | C/G | — | uncertain significance |
| rs2543437196 | 17:2,266,342 | C/T | — | uncertain significance |
| rs370623935 | 17:2,266,367 | G/A | — | uncertain significance |
| rs776543388 | 17:2,266,414 | C/T | — | uncertain significance |
| rs145512575 | 17:2,266,779 | C/G | — | uncertain significance |
| rs17853888 | 17:2,266,816 | C/T | — | uncertain significance |
| rs754318308 | 17:2,266,850 | G/A | — | uncertain significance |
| rs779766103 | 17:2,266,856 | G/A | — | uncertain significance |
| rs762265392 | 17:2,267,357 | A/C | — | uncertain significance |
| rs149698658 | 17:2,267,370 | G/A | — | benign |
| rs150468645 | 17:2,267,891 | G/A | — | uncertain significance |
| rs1471397661 | 17:2,268,223 | G/C | — | uncertain significance |
| rs779416894 | 17:2,268,239 | C/T | — | uncertain significance |
| rs780068520 | 17:2,268,549 | G/A | — | uncertain significance |
| rs200000645 | 17:2,268,554 | G/T | — | uncertain significance |
| rs1185006818 | 17:2,268,578 | G/A | — | uncertain significance |
| rs144134323 | 17:2,268,590 | G/A | — | uncertain significance |
| rs746506441 | 17:2,268,617 | G/A | — | uncertain significance |
| rs138764086 | 17:2,268,629 | G/A | — | uncertain significance |
| rs761309277 | 17:2,270,595 | G/A | — | uncertain significance |
| rs762168555 | 17:2,270,600 | G/A | — | uncertain significance |
| rs201474576 | 17:2,270,691 | C/T | — | uncertain significance |
| rs74862256 | 17:2,274,557 | C/T | — | benign |
| rs145862692 | 17:2,274,573 | G/A | — | uncertain significance |
| rs202161088 | 17:2,275,527 | G/A | — | uncertain significance |
| rs2543595599 | 17:2,275,648 | T/G | — | uncertain significance |
| rs864622032 | 17:2,275,690 | G/A | — | uncertain significance |
| rs185126674 | 17:2,275,701 | C/T | — | benign |
| rs141360605 | 17:2,275,735 | G/A | — | uncertain significance |
| rs571551748 | 17:2,275,736 | C/T | — | uncertain significance |
| rs755962907 | 17:2,275,774 | G/A | — | uncertain significance |
| rs771821873 | 17:2,276,286 | G/A | — | uncertain significance |
| rs776236090 | 17:2,276,295 | G/A | — | uncertain significance |
| rs61733096 | 17:2,276,707 | G/A | — | benign |
| rs200006896 | 17:2,276,713 | C/T | — | uncertain significance |
| rs769947881 | 17:2,276,752 | G/T | — | uncertain significance |
| rs377210088 | 17:2,276,757 | G/A | — | uncertain significance |
| rs2543617878 | 17:2,276,767 | T/C | — | uncertain significance |
| rs558900741 | 17:2,276,772 | C/T | — | uncertain significance |
| rs779955430 | 17:2,276,773 | G/A | — | uncertain significance |
| rs2543618242 | 17:2,276,776 | T/G | — | uncertain significance |
| rs148945300 | 17:2,278,912 | G/A | — | uncertain significance |
| rs183516323 | 17:2,278,951 | C/T | — | uncertain significance |
| rs370950981 | 17:2,279,026 | G/C | — | uncertain significance |
| rs2066107295 | 17:2,279,044 | T/C | — | uncertain significance |
| rs572563546 | 17:2,279,048 | G/A | — | uncertain significance |
| rs143622489 | 17:2,279,080 | G/C | — | uncertain significance |
| rs147179672 | 17:2,279,108 | C/G | — | uncertain significance |
| rs765711090 | 17:2,279,122 | C/A | — | uncertain significance |
| rs563979526 | 17:2,279,143 | G/T | — | uncertain significance |
| rs770420472 | 17:2,279,164 | T/G | — | uncertain significance |
| rs144506785 | 17:2,279,432 | T/C | — | uncertain significance |
| rs17853890 | 17:2,279,445 | C/A | — | uncertain significance |
| rs761413413 | 17:2,279,488 | A/G | — | uncertain significance |
| rs1193271501 | 17:2,279,503 | T/C | — | uncertain significance |
| rs779265028 | 17:2,279,536 | C/G | — | uncertain significance |
| rs745356247 | 17:2,280,037 | G/C | — | uncertain significance |
| rs767384666 | 17:2,282,453 | G/A | — | uncertain significance |
| rs1489054994 | 17:2,282,737 | C/T | — | uncertain significance |
| rs148238886 | 17:2,282,743 | G/A | — | uncertain significance |
| rs373345397 | 17:2,282,762 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.