SH3RF2
SH3 domain containing ring finger 2
Summary
Enables protein phosphatase 1 binding activity and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of JNK cascade; protein autoubiquitination; and regulation of protein metabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants44 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs150590690 | 5:145,317,535 | G/A | — | uncertain significance |
| rs200055659 | 5:145,317,633 | C/T | — | uncertain significance |
| rs752236375 | 5:145,317,639 | C/T | — | uncertain significance |
| rs199768544 | 5:145,317,670 | T/C | — | uncertain significance |
| rs534789556 | 5:145,317,734 | C/G | — | uncertain significance |
| rs758709823 | 5:145,317,780 | C/A | — | uncertain significance |
| rs1388290172 | 5:145,317,796 | G/C | — | uncertain significance |
| rs1435580284 | 5:145,317,805 | A/C | — | uncertain significance |
| rs749544058 | 5:145,317,807 | C/T | — | uncertain significance |
| rs200832314 | 5:145,379,849 | A/G | — | uncertain significance |
| rs139877242 | 5:145,379,852 | G/A | — | uncertain significance |
| rs1419357701 | 5:145,379,874 | G/T | — | uncertain significance |
| rs529406915 | 5:145,379,880 | C/T | — | uncertain significance |
| rs373312426 | 5:145,383,625 | A/G | — | uncertain significance |
| rs764971542 | 5:145,383,628 | T/G | — | uncertain significance |
| rs750280738 | 5:145,383,639 | A/C | — | uncertain significance |
| rs1251613488 | 5:145,383,646 | G/A | — | uncertain significance |
| rs139747301 | 5:145,393,322 | G/A | — | uncertain significance |
| rs370632302 | 5:145,393,349 | G/A | — | uncertain significance |
| rs150965707 | 5:145,393,578 | C/A | — | uncertain significance |
| rs186498547 | 5:145,423,858 | C/T | intron variant | — |
| rs1233044439 | 5:145,428,667 | A/G | — | uncertain significance |
| rs138174522 | 5:145,428,677 | T/G | — | uncertain significance |
| rs751401833 | 5:145,428,741 | A/T | — | uncertain significance |
| rs139696891 | 5:145,428,783 | A/G | — | uncertain significance |
| rs747775775 | 5:145,428,792 | G/A | — | uncertain significance |
| rs144355535 | 5:145,435,569 | C/T | — | uncertain significance |
| rs751030800 | 5:145,435,587 | A/G | — | likely benign |
| rs200571233 | 5:145,435,709 | A/C | — | uncertain significance |
| rs1023337569 | 5:145,435,720 | G/A | — | uncertain significance |
| rs373327542 | 5:145,435,758 | C/T | — | uncertain significance |
| rs747678660 | 5:145,439,458 | G/A | — | uncertain significance |
| rs769419482 | 5:145,439,461 | A/G | — | uncertain significance |
| rs141779033 | 5:145,439,473 | G/A | — | uncertain significance |
| rs2532615897 | 5:145,439,564 | C/T | — | uncertain significance |
| rs543563186 | 5:145,439,603 | C/T | — | uncertain significance |
| rs149337508 | 5:145,439,634 | G/C | — | uncertain significance |
| rs767187354 | 5:145,439,641 | G/A | — | uncertain significance |
| rs112543445 | 5:145,439,648 | G/A | — | uncertain significance |
| rs139582730 | 5:145,439,660 | C/T | — | uncertain significance |
| rs777133649 | 5:145,439,709 | G/C | — | uncertain significance |
| rs1298913682 | 5:145,439,780 | T/A | — | uncertain significance |
| rs756609677 | 5:145,441,999 | C/A | — | uncertain significance |
| rs142456711 | 5:145,442,061 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.