SH3RF2

SH3 domain containing ring finger 2

Summary

Enables protein phosphatase 1 binding activity and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of JNK cascade; protein autoubiquitination; and regulation of protein metabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants44 total

rsidPosition (GRCh37)AllelesClassClinVar
rs1505906905:145,317,535G/Auncertain significance
rs2000556595:145,317,633C/Tuncertain significance
rs7522363755:145,317,639C/Tuncertain significance
rs1997685445:145,317,670T/Cuncertain significance
rs5347895565:145,317,734C/Guncertain significance
rs7587098235:145,317,780C/Auncertain significance
rs13882901725:145,317,796G/Cuncertain significance
rs14355802845:145,317,805A/Cuncertain significance
rs7495440585:145,317,807C/Tuncertain significance
rs2008323145:145,379,849A/Guncertain significance
rs1398772425:145,379,852G/Auncertain significance
rs14193577015:145,379,874G/Tuncertain significance
rs5294069155:145,379,880C/Tuncertain significance
rs3733124265:145,383,625A/Guncertain significance
rs7649715425:145,383,628T/Guncertain significance
rs7502807385:145,383,639A/Cuncertain significance
rs12516134885:145,383,646G/Auncertain significance
rs1397473015:145,393,322G/Auncertain significance
rs3706323025:145,393,349G/Auncertain significance
rs1509657075:145,393,578C/Auncertain significance
rs1864985475:145,423,858C/Tintron variant
rs12330444395:145,428,667A/Guncertain significance
rs1381745225:145,428,677T/Guncertain significance
rs7514018335:145,428,741A/Tuncertain significance
rs1396968915:145,428,783A/Guncertain significance
rs7477757755:145,428,792G/Auncertain significance
rs1443555355:145,435,569C/Tuncertain significance
rs7510308005:145,435,587A/Glikely benign
rs2005712335:145,435,709A/Cuncertain significance
rs10233375695:145,435,720G/Auncertain significance
rs3733275425:145,435,758C/Tuncertain significance
rs7476786605:145,439,458G/Auncertain significance
rs7694194825:145,439,461A/Guncertain significance
rs1417790335:145,439,473G/Auncertain significance
rs25326158975:145,439,564C/Tuncertain significance
rs5435631865:145,439,603C/Tuncertain significance
rs1493375085:145,439,634G/Cuncertain significance
rs7671873545:145,439,641G/Auncertain significance
rs1125434455:145,439,648G/Auncertain significance
rs1395827305:145,439,660C/Tuncertain significance
rs7771336495:145,439,709G/Cuncertain significance
rs12989136825:145,439,780T/Auncertain significance
rs7566096775:145,441,999C/Auncertain significance
rs1424567115:145,442,061G/Auncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.