SIGIRR
single Ig and TIR domain containing
Summary
Involved in negative regulation of Toll signaling pathway. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants38 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs771122223 | 11:405,907 | C/T | — | uncertain significance |
| rs2539284032 | 11:405,926 | G/T | — | uncertain significance |
| rs140291506 | 11:405,958 | C/G | — | uncertain significance |
| rs1410814233 | 11:405,980 | G/A | — | likely benign |
| rs2539284378 | 11:405,994 | C/G | — | uncertain significance |
| rs1373226988 | 11:406,024 | G/C | — | uncertain significance |
| rs758352193 | 11:406,054 | G/A | — | uncertain significance |
| rs2539286299 | 11:406,351 | A/T | — | uncertain significance |
| rs533489165 | 11:406,387 | A/C | — | uncertain significance |
| rs569951384 | 11:406,440 | G/T | — | uncertain significance |
| rs529333220 | 11:406,441 | T/C | — | uncertain significance |
| rs191365437 | 11:406,459 | G/A | — | uncertain significance |
| rs376778033 | 11:406,492 | C/T | — | uncertain significance |
| rs2539287456 | 11:406,528 | G/A | — | uncertain significance |
| rs2539287462 | 11:406,529 | A/T | — | uncertain significance |
| rs150864495 | 11:406,531 | G/A | — | uncertain significance |
| rs777476009 | 11:406,892 | C/A | — | uncertain significance |
| rs773308873 | 11:406,921 | G/A | — | likely benign |
| rs763801811 | 11:406,935 | C/A | — | uncertain significance |
| rs766310574 | 11:407,126 | G/C | — | uncertain significance |
| rs1162462305 | 11:407,131 | C/A | — | uncertain significance |
| rs1220618823 | 11:407,143 | A/G | — | uncertain significance |
| rs2539292017 | 11:407,162 | G/A | — | uncertain significance |
| rs1245665145 | 11:407,529 | C/T | — | uncertain significance |
| rs376859577 | 11:407,550 | G/T | — | uncertain significance |
| rs2539296769 | 11:407,856 | G/A | — | uncertain significance |
| rs1233294540 | 11:407,862 | C/T | — | uncertain significance |
| rs373782732 | 11:407,892 | C/T | — | uncertain significance |
| rs750809277 | 11:407,904 | G/C | — | uncertain significance |
| rs778609327 | 11:407,937 | C/G | — | uncertain significance |
| rs143116663 | 11:408,093 | G/A | — | uncertain significance |
| rs752468430 | 11:408,108 | T/G | — | uncertain significance |
| rs117739035 | 11:408,174 | G/T | — | benign |
| rs73400585 | 11:408,191 | C/G | — | benign |
| rs142640604 | 11:408,725 | C/G | — | uncertain significance |
| rs941659379 | 11:408,734 | A/C | — | uncertain significance |
| rs113922210 | 11:408,745 | G/A | — | benign |
| rs756324224 | 11:408,876 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.