SLC15A1
solute carrier family 15 member 1
Summary
This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. [provided by RefSeq, Apr 2010]
Known Variants48 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1289389 | 13:99,336,290 | C/T | 3 prime UTR variant | — |
| rs4646234 | 13:99,336,380 | T/C | 3 prime UTR variant | — |
| rs770769408 | 13:99,337,102 | C/T | — | uncertain significance |
| rs769397773 | 13:99,337,105 | G/C | — | uncertain significance |
| rs550282841 | 13:99,337,140 | C/G | — | uncertain significance |
| rs2548116363 | 13:99,338,523 | T/C | — | uncertain significance |
| rs778277283 | 13:99,338,532 | G/A | — | uncertain significance |
| rs538328984 | 13:99,338,537 | C/T | — | uncertain significance |
| rs2548116962 | 13:99,339,837 | G/C | — | uncertain significance |
| rs766408298 | 13:99,339,921 | T/C | — | uncertain significance |
| rs761412933 | 13:99,340,570 | A/G | — | uncertain significance |
| rs2548117428 | 13:99,340,603 | A/G | — | uncertain significance |
| rs750680428 | 13:99,340,725 | T/C | — | likely benign |
| rs143400114 | 13:99,340,727 | C/T | — | uncertain significance |
| rs2087950423 | 13:99,340,793 | A/G | — | uncertain significance |
| rs8187828 | 13:99,354,754 | T/C | — | benign |
| rs62637593 | 13:99,356,560 | G/A | — | uncertain significance |
| rs2088094399 | 13:99,356,580 | T/A | — | uncertain significance |
| rs368610950 | 13:99,356,673 | G/A | — | uncertain significance |
| rs8187836 | 13:99,358,478 | G/A | — | benign |
| rs150050510 | 13:99,358,517 | A/G | — | benign |
| rs151053191 | 13:99,360,957 | C/T | — | uncertain significance |
| rs1426484528 | 13:99,361,008 | T/C | — | uncertain significance |
| rs770486047 | 13:99,361,893 | C/T | — | uncertain significance |
| rs1259723625 | 13:99,362,143 | G/C | — | uncertain significance |
| rs369301364 | 13:99,364,166 | G/A | — | likely benign |
| rs765916431 | 13:99,364,193 | C/T | — | uncertain significance |
| rs540714136 | 13:99,364,762 | T/C | — | uncertain significance |
| rs529976819 | 13:99,364,813 | T/C | — | uncertain significance |
| rs762410666 | 13:99,368,154 | C/T | — | uncertain significance |
| rs147777498 | 13:99,368,168 | C/G | — | uncertain significance |
| rs761207197 | 13:99,368,172 | G/A | — | uncertain significance |
| rs940785611 | 13:99,371,548 | G/T | — | uncertain significance |
| rs192394513 | 13:99,373,756 | C/T | — | likely benign |
| rs533040643 | 13:99,373,761 | G/A | — | uncertain significance |
| rs775540418 | 13:99,373,780 | C/G | — | uncertain significance |
| rs1398852589 | 13:99,373,835 | T/C | — | uncertain significance |
| rs2088261718 | 13:99,374,071 | A/G | — | uncertain significance |
| rs8187820 | 13:99,376,167 | C/T | — | benign |
| rs2297322 | 13:99,376,181 | C/G | missense variant | — |
| rs148742760 | 13:99,376,253 | A/G | — | uncertain significance |
| rs2088279789 | 13:99,376,269 | A/T | — | uncertain significance |
| rs8187823 | 13:99,376,273 | C/T | — | benign |
| rs199996553 | 13:99,378,462 | C/T | — | uncertain significance |
| rs8187817 | 13:99,378,642 | A/T | missense variant | — |
| rs772104767 | 13:99,378,667 | C/T | — | uncertain significance |
| rs1594000640 | 13:99,378,681 | C/T | — | uncertain significance |
| rs9582259 | 13:99,385,990 | T/G | intron variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.