SLC2A3
solute carrier family 2 member 3
Summary
Enables D-glucose binding activity; dehydroascorbic acid transmembrane transporter activity; and hexose transmembrane transporter activity. Involved in D-glucose import across plasma membrane; galactose transmembrane transport; and transport across blood-brain barrier. Located in aggresome and plasma membrane. Biomarker of Alzheimer's disease; acanthosis nigricans; diabetes mellitus; and type 2 diabetes mellitus. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants32 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs12842 | 12:8,072,008 | T/C | 3 prime UTR variant | — |
| rs571923754 | 12:8,073,084 | T/A | — | — |
| rs780023625 | 12:8,074,041 | C/T | — | uncertain significance |
| rs777199710 | 12:8,074,139 | C/T | — | uncertain significance |
| rs748629602 | 12:8,074,214 | G/C | — | uncertain significance |
| rs753584145 | 12:8,075,408 | T/A | — | likely benign |
| rs201655602 | 12:8,075,423 | G/A | — | benign |
| rs760162078 | 12:8,075,463 | T/C | — | uncertain significance |
| rs975763809 | 12:8,075,485 | T/C | — | uncertain significance |
| rs1385678344 | 12:8,075,562 | A/C | — | uncertain significance |
| rs776453061 | 12:8,075,580 | A/G | — | uncertain significance |
| rs3931701 | 12:8,077,002 | C/T | — | benign |
| rs769669713 | 12:8,077,076 | G/A | — | uncertain significance |
| rs1162192065 | 12:8,082,298 | C/A | — | uncertain significance |
| rs1269936999 | 12:8,082,315 | G/A | — | uncertain significance |
| rs1441968959 | 12:8,082,329 | A/G | — | uncertain significance |
| rs2497875924 | 12:8,082,330 | T/C | — | uncertain significance |
| rs775960896 | 12:8,082,396 | T/C | — | uncertain significance |
| rs1194647146 | 12:8,083,108 | A/G | — | uncertain significance |
| rs561258995 | 12:8,083,195 | G/A | — | uncertain significance |
| rs182556380 | 12:8,083,246 | C/T | — | likely benign |
| rs764642943 | 12:8,083,861 | C/T | — | likely benign |
| rs150412980 | 12:8,083,865 | G/T | — | likely benign |
| rs2497879506 | 12:8,083,885 | T/A | — | uncertain significance |
| rs1350360519 | 12:8,083,906 | C/G | — | uncertain significance |
| rs1401957285 | 12:8,084,032 | A/G | — | likely benign |
| rs755142581 | 12:8,084,071 | T/C | — | uncertain significance |
| rs764323738 | 12:8,085,623 | C/G | — | uncertain significance |
| rs148937156 | 12:8,085,692 | G/A | — | likely benign |
| rs761819966 | 12:8,085,697 | G/A | — | uncertain significance |
| rs189457983 | 12:8,085,703 | C/G | — | likely benign |
| rs1325500356 | 12:8,085,721 | T/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.