SLC7A5
solute carrier family 7 member 5
Summary
Enables L-amino acid transmembrane transporter activity and secondary active transmembrane transporter activity. Involved in carboxylic acid transport; thyroid hormone transport; and xenobiotic transport. Located in several cellular components, including apical plasma membrane; cytosol; and microvillus membrane. Part of amino acid transport complex. Implicated in cholangiocarcinoma; colon cancer; hepatocellular carcinoma; and lung squamous cell carcinoma. Biomarker of esophagitis; gastrointestinal system cancer (multiple); malignant astrocytoma (multiple); and respiratory system cancer (multiple). [provided by Alliance of Genome Resources, Apr 2025]
Known Variants65 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs141073967 | 16:87,866,567 | G/C | — | likely benign |
| rs2508268031 | 16:87,866,590 | G/T | — | uncertain significance |
| rs2054951814 | 16:87,866,601 | A/T | — | uncertain significance |
| rs759073537 | 16:87,868,023 | T/C | — | uncertain significance |
| rs564461426 | 16:87,868,025 | C/A | — | uncertain significance |
| rs879766630 | 16:87,868,028 | T/C | — | uncertain significance |
| rs146583737 | 16:87,868,062 | C/A | — | uncertain significance |
| rs11541881 | 16:87,868,141 | G/C | — | benign |
| rs747038000 | 16:87,868,146 | C/T | — | uncertain significance |
| rs1038464020 | 16:87,868,185 | G/C | — | uncertain significance |
| rs1157166399 | 16:87,868,188 | C/T | — | uncertain significance |
| rs55777228 | 16:87,869,313 | T/G | — | — |
| rs371378644 | 16:87,870,098 | G/T | — | likely benign |
| rs769384114 | 16:87,870,128 | C/A | — | uncertain significance |
| rs777097653 | 16:87,870,154 | C/T | — | uncertain significance |
| rs777326719 | 16:87,870,250 | C/G | — | uncertain significance |
| rs986514243 | 16:87,870,257 | G/T | — | likely benign |
| rs2230174 | 16:87,871,460 | G/A | — | benign |
| rs757972971 | 16:87,871,467 | G/A | missense variant | uncertain significance |
| rs33966404 | 16:87,872,314 | G/A | — | benign |
| rs1060251 | 16:87,872,355 | G/A | — | benign |
| rs777967482 | 16:87,872,373 | G/A | — | likely benign |
| rs771638454 | 16:87,872,399 | C/T | — | uncertain significance |
| rs780213182 | 16:87,873,310 | C/T | — | uncertain significance |
| rs202090522 | 16:87,873,327 | G/A | — | uncertain significance |
| rs750247543 | 16:87,874,044 | T/C | — | uncertain significance |
| rs2143738378 | 16:87,874,689 | G/A | — | uncertain significance |
| rs1060250 | 16:87,874,736 | G/C | — | benign |
| rs17853937 | 16:87,874,758 | T/A | — | benign |
| rs34508683 | 16:87,876,375 | T/G | — | — |
| rs34380332 | 16:87,876,500 | A/G | regulatory region variant | — |
| rs28611500 | 16:87,876,812 | T/C | regulatory region variant | — |
| rs57455079 | 16:87,877,312 | G/A | intron variant | — |
| rs4843270 | 16:87,878,072 | C/A | regulatory region variant | — |
| rs8051149 | 16:87,878,822 | G/A | regulatory region variant | — |
| rs35459492 | 16:87,878,883 | C/T | — | — |
| rs139698583 | 16:87,880,570 | C/T | intron variant | — |
| rs876987 | 16:87,882,209 | A/C | — | — |
| rs1007479368 | 16:87,885,382 | C/A | — | uncertain significance |
| rs151257488 | 16:87,885,387 | C/T | — | likely benign |
| rs33938662 | 16:87,885,397 | G/A | — | benign |
| rs549051612 | 16:87,885,442 | G/C | — | likely benign |
| rs68149176 | 16:87,886,490 | C/T | regulatory region variant | — |
| rs67971539 | 16:87,886,726 | T/A | regulatory region variant | — |
| rs4240801 | 16:87,889,155 | C/G | — | — |
| rs4240802 | 16:87,889,160 | T/C | regulatory region variant | — |
| rs181399522 | 16:87,899,906 | G/A | regulatory region variant | — |
| rs369279771 | 16:87,901,736 | A/C | — | — |
| rs1446589926 | 16:87,902,502 | C/A | — | uncertain significance |
| rs771592683 | 16:87,902,535 | G/A | — | uncertain significance |
| rs774535808 | 16:87,902,570 | G/A | — | likely benign |
| rs2508406623 | 16:87,902,607 | C/T | — | uncertain significance |
| rs33913122 | 16:87,902,642 | G/A | — | benign |
| rs17853938 | 16:87,902,684 | G/T | — | benign |
| rs2055499060 | 16:87,902,686 | C/T | — | uncertain significance |
| rs760337387 | 16:87,902,878 | T/C | — | uncertain significance |
| rs2508407597 | 16:87,902,897 | C/G | — | likely benign |
| rs148183733 | 16:87,902,907 | C/T | — | likely benign |
| rs759266297 | 16:87,902,935 | C/A | — | uncertain significance |
| rs2508407966 | 16:87,902,953 | T/A | — | uncertain significance |
| rs1042735746 | 16:87,902,961 | C/G | — | uncertain significance |
| rs1191984510 | 16:87,902,983 | C/T | — | uncertain significance |
| rs1299676066 | 16:87,902,998 | G/C | — | uncertain significance |
| rs33983951 | 16:87,903,012 | G/A | — | benign |
| rs779157899 | 16:87,903,029 | G/A | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.