SLF2
SMC5/6 complex localization factor 2
Summary
Enables ubiquitin protein ligase binding activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization to site of double-strand break. Located in PML body; chromatin; and site of double-strand break. Implicated in mosaic variegated aneuploidy syndrome. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants68 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2493326486 | 10:102,672,908 | C/T | — | uncertain significance |
| rs3802725 | 10:102,673,063 | G/T | regulatory region variant | — |
| rs73336283 | 10:102,673,842 | C/G | — | — |
| rs11190751 | 10:102,674,637 | C/T | — | — |
| rs41291452 | 10:102,676,389 | A/G | — | uncertain significance |
| rs199775720 | 10:102,676,452 | G/T | — | uncertain significance |
| rs374898849 | 10:102,676,477 | T/C | — | uncertain significance |
| rs748706051 | 10:102,676,539 | C/T | — | uncertain significance |
| rs367671496 | 10:102,676,540 | G/A | — | uncertain significance |
| rs2493339064 | 10:102,676,543 | C/T | — | uncertain significance |
| rs35608448 | 10:102,676,576 | A/G | — | conflicting classifications of pathogenicity |
| rs114300819 | 10:102,676,591 | A/G | — | benign |
| rs1324638240 | 10:102,676,707 | G/C | — | uncertain significance |
| rs1212696529 | 10:102,676,710 | C/T | — | pathogenic |
| rs201989827 | 10:102,676,722 | A/G | — | uncertain significance |
| rs139059266 | 10:102,676,783 | G/A | — | uncertain significance |
| rs147132029 | 10:102,676,822 | C/T | — | uncertain significance |
| rs753432952 | 10:102,676,918 | A/G | — | uncertain significance |
| rs2493341630 | 10:102,676,975 | G/T | — | uncertain significance |
| rs1849435094 | 10:102,677,019 | A/G | — | uncertain significance |
| rs1224735342 | 10:102,677,025 | A/G | — | likely benign |
| rs765449550 | 10:102,683,849 | G/A | — | uncertain significance |
| rs1239119354 | 10:102,683,863 | C/T | — | uncertain significance |
| rs2493362024 | 10:102,683,887 | C/T | — | uncertain significance |
| rs150772167 | 10:102,683,920 | C/T | — | likely benign |
| rs2493362978 | 10:102,684,035 | T/C | — | uncertain significance |
| rs567033022 | 10:102,684,118 | A/G | — | uncertain significance |
| rs763021611 | 10:102,684,149 | C/T | — | uncertain significance |
| rs1471541148 | 10:102,684,268 | G/A | — | uncertain significance |
| rs138914513 | 10:102,684,299 | A/G | — | uncertain significance |
| rs1200636964 | 10:102,684,313 | A/G | — | uncertain significance |
| rs569503980 | 10:102,684,352 | G/A | — | uncertain significance |
| rs771148586 | 10:102,684,395 | G/T | — | uncertain significance |
| rs2493365906 | 10:102,684,448 | C/T | — | uncertain significance |
| rs771058519 | 10:102,684,488 | C/T | — | uncertain significance |
| rs766030214 | 10:102,684,519 | T/A | — | uncertain significance |
| rs2493366745 | 10:102,684,545 | A/G | — | uncertain significance |
| rs35532139 | 10:102,684,656 | A/G | — | likely benign |
| rs201498269 | 10:102,684,658 | C/G | — | uncertain significance |
| rs751332322 | 10:102,684,689 | C/T | — | uncertain significance |
| rs750469615 | 10:102,684,698 | A/G | — | uncertain significance |
| rs779981337 | 10:102,684,710 | C/G | — | uncertain significance |
| rs1980632 | 10:102,686,901 | G/A | — | — |
| rs1282543962 | 10:102,689,107 | C/A | — | uncertain significance |
| rs2493381740 | 10:102,689,110 | A/G | — | uncertain significance |
| rs746661266 | 10:102,689,138 | A/G | — | uncertain significance |
| rs150795530 | 10:102,689,728 | A/C | — | uncertain significance |
| rs2493384107 | 10:102,689,748 | T/C | — | uncertain significance |
| rs117803487 | 10:102,690,797 | G/T | — | uncertain significance |
| rs1368824402 | 10:102,697,161 | G/A | — | uncertain significance |
| rs770345013 | 10:102,697,178 | A/C | — | uncertain significance |
| rs1266675910 | 10:102,698,421 | A/T | — | pathogenic |
| rs775271431 | 10:102,698,432 | G/A | — | uncertain significance |
| rs145182528 | 10:102,703,847 | T/G | — | uncertain significance |
| rs1433161517 | 10:102,705,105 | T/A | — | uncertain significance |
| rs1455778145 | 10:102,705,120 | G/A | — | uncertain significance |
| rs1175310288 | 10:102,705,187 | T/G | — | uncertain significance |
| rs2493424950 | 10:102,705,234 | A/G | — | uncertain significance |
| rs138249057 | 10:102,705,243 | A/C | — | uncertain significance |
| rs2493428922 | 10:102,706,841 | C/T | — | uncertain significance |
| rs138690129 | 10:102,707,596 | A/C | — | uncertain significance |
| rs752283411 | 10:102,709,921 | A/G | — | uncertain significance |
| rs367992941 | 10:102,719,230 | A/G | — | uncertain significance |
| rs755773064 | 10:102,719,239 | T/C | — | uncertain significance |
| rs770442229 | 10:102,719,243 | G/A | — | uncertain significance |
| rs2493460831 | 10:102,719,275 | T/G | — | uncertain significance |
| rs11190767 | 10:102,720,754 | T/A | regulatory region variant | — |
| rs11190774 | 10:102,724,861 | T/G | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.