SNX16
sorting nexin 16
Summary
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The protein encoded by this gene associates with late endosome membranes as is involved in tubule formation, cholesterol transport, and transport of tetraspanin CD81. The encoded protein also inhibits cell migration and tumorigenesis. [provided by RefSeq, Jan 2017]
Known Variants22 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs775224639 | 8:82,713,799 | C/T | — | uncertain significance |
| rs1809689170 | 8:82,713,800 | T/C | — | uncertain significance |
| rs750152413 | 8:82,713,815 | G/T | — | uncertain significance |
| rs755297901 | 8:82,713,819 | A/T | — | uncertain significance |
| rs2487532715 | 8:82,713,826 | G/C | — | uncertain significance |
| rs753090502 | 8:82,713,827 | C/G | — | uncertain significance |
| rs143438793 | 8:82,714,652 | G/C | — | uncertain significance |
| rs146885039 | 8:82,715,340 | C/G | — | uncertain significance |
| rs201841865 | 8:82,715,411 | A/G | — | uncertain significance |
| rs200338079 | 8:82,715,444 | T/C | — | uncertain significance |
| rs2600605 | 8:82,720,760 | G/A | coding sequence variant | — |
| rs1370845699 | 8:82,727,588 | C/T | — | uncertain significance |
| rs1181192931 | 8:82,727,610 | G/C | — | uncertain significance |
| rs1810885210 | 8:82,736,040 | C/T | — | uncertain significance |
| rs139295703 | 8:82,736,094 | C/T | — | uncertain significance |
| rs2487682928 | 8:82,736,111 | T/C | — | uncertain significance |
| rs2487769731 | 8:82,751,884 | A/G | — | uncertain significance |
| rs2487770048 | 8:82,751,918 | T/C | — | uncertain significance |
| rs376327128 | 8:82,751,936 | G/T | — | uncertain significance |
| rs752908869 | 8:82,752,023 | C/T | — | uncertain significance |
| rs772801589 | 8:82,752,028 | G/A | — | uncertain significance |
| rs1811655128 | 8:82,752,037 | T/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.