SOCS1
suppressor of cytokine signaling 1
Summary
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]
Known Variants52 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs4780355 | 16:11,347,858 | T/C | regulatory region variant | no classification for the single variant |
| rs33932899 | 16:11,348,211 | C/T | — | — |
| rs2511258912 | 16:11,348,737 | A/G | — | likely benign |
| rs139221703 | 16:11,348,739 | G/A | — | benign |
| rs140266462 | 16:11,348,759 | G/A | — | uncertain significance |
| rs371272867 | 16:11,348,766 | G/C | — | uncertain significance |
| rs201368715 | 16:11,348,772 | G/A | — | benign |
| rs2141124327 | 16:11,348,776 | C/T | — | likely pathogenic |
| rs763639146 | 16:11,348,818 | G/A | — | uncertain significance |
| rs548254484 | 16:11,348,825 | C/T | — | uncertain significance |
| rs1412108457 | 16:11,348,848 | C/G | — | uncertain significance |
| rs1322228094 | 16:11,348,870 | C/A | — | uncertain significance |
| rs778937880 | 16:11,348,873 | C/T | — | uncertain significance |
| rs906125295 | 16:11,348,874 | G/T | — | pathogenic |
| rs2069578995 | 16:11,348,876 | A/G | — | pathogenic |
| rs2069579242 | 16:11,348,882 | C/A | — | likely pathogenic |
| rs1419164658 | 16:11,348,897 | G/A | — | uncertain significance |
| rs1378359515 | 16:11,348,903 | C/G | — | uncertain significance |
| rs765480579 | 16:11,348,912 | C/G | — | uncertain significance |
| rs112876299 | 16:11,348,915 | G/C | — | uncertain significance |
| rs587778693 | 16:11,348,938 | C/T | — | uncertain significance |
| rs1244284678 | 16:11,348,968 | G/C | — | pathogenic |
| rs1043628610 | 16:11,349,055 | C/A | — | uncertain significance |
| rs1467715276 | 16:11,349,074 | C/T | — | uncertain significance |
| rs766097160 | 16:11,349,109 | G/C | — | uncertain significance |
| rs1056014933 | 16:11,349,111 | G/A | — | likely benign |
| rs558823996 | 16:11,349,126 | G/A | — | likely benign |
| rs2141125120 | 16:11,349,144 | G/C | — | likely pathogenic |
| rs1489831608 | 16:11,349,181 | T/G | — | uncertain significance |
| rs748306213 | 16:11,349,186 | G/A | — | likely benign |
| rs776040600 | 16:11,349,187 | G/A | — | uncertain significance |
| rs760692169 | 16:11,349,191 | C/A | — | uncertain significance |
| rs985283832 | 16:11,349,196 | G/A | — | uncertain significance |
| rs768681189 | 16:11,349,197 | C/T | — | uncertain significance |
| rs867464575 | 16:11,349,230 | G/C | — | uncertain significance |
| rs998577469 | 16:11,349,233 | C/G | — | uncertain significance |
| rs1233626909 | 16:11,349,236 | C/T | — | uncertain significance |
| rs2141125364 | 16:11,349,241 | G/T | — | likely pathogenic |
| rs1249424944 | 16:11,349,256 | G/A | — | uncertain significance |
| rs2511259967 | 16:11,349,266 | C/T | — | uncertain significance |
| rs2069586831 | 16:11,349,272 | G/A | — | pathogenic |
| rs759348389 | 16:11,349,275 | G/A | — | uncertain significance |
| rs2511259988 | 16:11,349,280 | G/A | — | uncertain significance |
| rs537872317 | 16:11,349,290 | C/G | — | uncertain significance |
| rs778594186 | 16:11,349,296 | A/C | — | uncertain significance |
| rs2511260094 | 16:11,349,333 | C/T | — | uncertain significance |
| rs27829 | 16:11,349,403 | A/C | — | benign |
| rs243332 | 16:11,349,678 | C/T | regulatory region variant | — |
| rs33977706 | 16:11,350,155 | C/T | — | — |
| rs33989964 | 16:11,350,812 | — | — | — |
| rs193779 | 16:11,350,965 | G/A | regulatory region variant | — |
| rs243330 | 16:11,350,991 | C/G | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.