SOCS5

suppressor of cytokine signaling 5

Summary

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]

Known Variants42 total

rsidPosition (GRCh37)AllelesClassClinVar
rs344011072:46,972,768A/Cintron variant
rs75621732:46,976,217G/T
rs3678443232:46,985,686A/Guncertain significance
rs24655196072:46,985,725T/Auncertain significance
rs413952452:46,985,726C/Tbenign
rs1482638072:46,985,727G/Cuncertain significance
rs3682728002:46,985,763A/Guncertain significance
rs1508072172:46,985,795G/Cuncertain significance
rs2017379412:46,985,820A/Glikely benign
rs24655199212:46,985,841C/Auncertain significance
rs9331840832:46,985,851A/Cuncertain significance
rs1429655882:46,985,913T/Guncertain significance
rs7503787402:46,985,952G/Auncertain significance
rs7790760722:46,985,982G/Auncertain significance
rs7586552622:46,986,070G/Auncertain significance
rs7519252962:46,986,084G/Cuncertain significance
rs1437991892:46,986,102A/Guncertain significance
rs3737809212:46,986,141G/Auncertain significance
rs7509220892:46,986,168G/Auncertain significance
rs7805196232:46,986,171T/Guncertain significance
rs7797799132:46,986,196C/Guncertain significance
rs1381317262:46,986,202G/Cuncertain significance
rs3716476092:46,986,253G/Alikely benign
rs7688887612:46,986,282A/Guncertain significance
rs7745292742:46,986,283A/Guncertain significance
rs5496713042:46,986,511A/Guncertain significance
rs13102030072:46,986,523A/Guncertain significance
rs7501275762:46,986,552C/Tuncertain significance
rs12559400932:46,986,610G/Auncertain significance
rs24655213652:46,986,622C/Tuncertain significance
rs7548174602:46,986,654A/Guncertain significance
rs13632825152:46,986,690C/Tuncertain significance
rs1390243352:46,986,696A/Tuncertain significance
rs1498902532:46,986,700C/Tuncertain significance
rs24655215962:46,986,702G/Auncertain significance
rs414490442:46,986,809C/Abenign
rs7775742202:46,986,909C/Auncertain significance
rs7467601732:46,987,027C/Auncertain significance
rs3718588282:46,987,117G/Auncertain significance
rs617400362:46,987,145C/Tbenign
rs24655229762:46,987,179C/Tuncertain significance
rs7709597212:46,987,201A/Tuncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.