SPARC

secreted protein acidic and cysteine rich

Summary

This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015]

Known Variants189 total

rsidPosition (GRCh37)AllelesClassClinVar
rs10542045:151,042,550C/G—benign
rs10601515:151,042,984A/T—likely benign
rs12243780185:151,043,077G/C—uncertain significance
rs7458279335:151,043,085G/A—likely benign
rs10534115:151,043,103G/C—benign
rs7642704655:151,043,143G/C—uncertain significance
rs12694095095:151,043,145T/A—uncertain significance
rs1488831695:151,043,153G/A—likely benign
rs119503845:151,043,213G/A—benign
rs785378445:151,043,300C/T—likely benign
rs412905855:151,043,542C/G—likely benign
rs7599153245:151,043,639G/C—likely benign
rs7725226175:151,043,641C/T—likely benign
rs24801955765:151,043,658G/A—likely benign
rs7735577075:151,043,661G/A—likely benign
rs1436927735:151,043,670G/A—likely benign
rs5322178145:151,043,687C/T—uncertain significance
rs15619153965:151,043,688G/A—likely benign
rs1133138325:151,043,694C/T—likely benign
rs7559004295:151,043,705C/T—uncertain significance
rs7568101575:151,043,709G/C—uncertain significance
rs3732197015:151,043,715G/T—likely benign
rs5512412935:151,043,720C/T—uncertain significance
rs348278785:151,043,721G/A—likely benign
rs1427174645:151,043,728C/T—uncertain significance
rs7474477805:151,043,729G/A—uncertain significance
rs7770443915:151,043,736G/A—likely benign
rs10575176635:151,043,744C/Tmissense variantpathogenic
rs21130813925:151,043,748G/A—likely benign
rs13213645175:151,043,749G/C—uncertain significance
rs17605760705:151,043,750G/C—uncertain significance
rs21130814135:151,043,753T/C—uncertain significance
rs12358411335:151,043,760A/G—likely benign
rs3703280045:151,043,765G/A—uncertain significance
rs12176354665:151,043,770G/A—uncertain significance
rs1995455275:151,043,777G/A—likely benign
rs7523770985:151,043,780C/T—uncertain significance
rs13226872235:151,043,781G/A—likely benign
rs3738353685:151,043,802G/A—likely benign
rs17605783675:151,043,810G/A—likely benign
rs17605785255:151,043,815G/A—likely benign
rs1452924555:151,044,048C/T—likely benign
rs5424309805:151,045,646C/T—likely benign
rs24802000675:151,045,907G/A—likely benign
rs9546523475:151,045,908G/A—likely benign
rs7535236105:151,045,911T/G—likely benign
rs21130856005:151,045,914G/C—likely benign
rs412905875:151,045,923C/T—conflicting classifications of pathogenicity
rs7580341235:151,045,924G/A—likely benign
rs2018564325:151,045,950C/T—uncertain significance
rs7554761605:151,045,951G/A—likely benign
rs15815199265:151,045,954C/T—likely benign
rs17606202125:151,045,967G/A—uncertain significance
rs13433607885:151,045,990C/T—likely benign
rs7606150375:151,045,996G/A—likely benign
rs1415676255:151,045,999G/T—uncertain significance
rs1509106565:151,046,004G/A—uncertain significance
rs15815200895:151,046,011C/T—likely benign
rs1493067905:151,046,023G/A—benign
rs3690343015:151,046,042C/A—uncertain significance
rs3742878975:151,046,052T/A—uncertain significance
rs17606240905:151,046,055C/T—uncertain significance
rs7721634305:151,046,056A/G—likely benign
rs14180743685:151,046,076G/A—likely benign
rs12726097345:151,046,088G/A—likely benign
rs24802008985:151,046,089T/C—likely benign
rs1131872225:151,046,107C/T—likely benign
rs68928405:151,046,338T/C—benign
rs569160695:151,046,730A/G—benign
rs1826836555:151,046,904C/T—likely benign
rs7298535:151,046,928T/C—benign
rs7460709265:151,047,010G/T—likely benign
rs24802025185:151,047,017A/G—likely benign
rs21130882175:151,047,027C/A—uncertain significance
rs2007779495:151,047,030G/A—uncertain significance
rs15815209295:151,047,034C/T—likely benign
rs24802025985:151,047,042T/G—uncertain significance
rs7697152925:151,047,051G/A—likely benign
rs24802026865:151,047,071C/A—uncertain significance
rs3695019185:151,047,079C/G—likely benign
rs21130884385:151,047,091G/A—likely benign
rs7530672295:151,047,093C/T—uncertain significance
rs7741678695:151,047,094G/A—likely benign
rs23040495:151,047,100G/C—likely benign
rs1856848625:151,047,110C/T—uncertain significance
rs14073700195:151,047,114T/G—uncertain significance
rs10575176625:151,047,116C/Tmissense variantpathogenic
rs7655407295:151,047,123G/T—uncertain significance
rs1393405425:151,047,124G/A—likely benign
rs11790122445:151,047,126A/T—uncertain significance
rs3710653575:151,047,129C/T—uncertain significance
rs3764457355:151,047,130G/C—likely benign
rs7491860305:151,047,153G/C—uncertain significance
rs8872583525:151,047,159T/C—uncertain significance
rs24802029665:151,047,160G/A—likely benign
rs7718116435:151,047,176C/A—likely benign
rs14347257545:151,047,179G/T—likely benign
rs7495755:151,047,230A/C—benign
rs23471265:151,047,493C/T—benign
rs7531002335:151,049,238G/A—likely benign

Showing 100 of 189 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.