SPOPL

speckle type BTB/POZ protein like

Summary

Enables identical protein binding activity. Involved in negative regulation of protein ubiquitination and proteasome-mediated ubiquitin-dependent protein catabolic process. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants23 total

rsidPosition (GRCh37)AllelesClassClinVar
rs101703102:139,278,922G/C
rs5372897012:139,306,103C/G
rs24679263402:139,308,524G/Tuncertain significance
rs7668614092:139,308,534T/Guncertain significance
rs13247141802:139,308,570G/Auncertain significance
rs7643890732:139,308,597G/Cuncertain significance
rs7468502882:139,308,604G/Auncertain significance
rs5565045022:139,310,197G/Tuncertain significance
rs5764483912:139,310,198C/Tuncertain significance
rs24679282642:139,310,242A/Cuncertain significance
rs14172047212:139,316,596G/Auncertain significance
rs5625405652:139,316,873C/Tuncertain significance
rs13630035782:139,316,875A/Guncertain significance
rs7590362962:139,318,379G/Alikely benign
rs12489145422:139,318,396T/Glikely benign
rs24673262812:139,322,325T/Guncertain significance
rs14173157622:139,322,387A/Tuncertain significance
rs7526931542:139,326,507C/Auncertain significance
rs14013678092:139,326,510G/Auncertain significance
rs13177924722:139,326,513A/Glikely benign
rs7771046652:139,326,562C/Tuncertain significance
rs7641747032:139,326,607G/Auncertain significance
rs7453592132:139,326,633C/Tuncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.