SPOPL
speckle type BTB/POZ protein like
Summary
Enables identical protein binding activity. Involved in negative regulation of protein ubiquitination and proteasome-mediated ubiquitin-dependent protein catabolic process. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants23 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs10170310 | 2:139,278,922 | G/C | — | — |
| rs537289701 | 2:139,306,103 | C/G | — | — |
| rs2467926340 | 2:139,308,524 | G/T | — | uncertain significance |
| rs766861409 | 2:139,308,534 | T/G | — | uncertain significance |
| rs1324714180 | 2:139,308,570 | G/A | — | uncertain significance |
| rs764389073 | 2:139,308,597 | G/C | — | uncertain significance |
| rs746850288 | 2:139,308,604 | G/A | — | uncertain significance |
| rs556504502 | 2:139,310,197 | G/T | — | uncertain significance |
| rs576448391 | 2:139,310,198 | C/T | — | uncertain significance |
| rs2467928264 | 2:139,310,242 | A/C | — | uncertain significance |
| rs1417204721 | 2:139,316,596 | G/A | — | uncertain significance |
| rs562540565 | 2:139,316,873 | C/T | — | uncertain significance |
| rs1363003578 | 2:139,316,875 | A/G | — | uncertain significance |
| rs759036296 | 2:139,318,379 | G/A | — | likely benign |
| rs1248914542 | 2:139,318,396 | T/G | — | likely benign |
| rs2467326281 | 2:139,322,325 | T/G | — | uncertain significance |
| rs1417315762 | 2:139,322,387 | A/T | — | uncertain significance |
| rs752693154 | 2:139,326,507 | C/A | — | uncertain significance |
| rs1401367809 | 2:139,326,510 | G/A | — | uncertain significance |
| rs1317792472 | 2:139,326,513 | A/G | — | likely benign |
| rs777104665 | 2:139,326,562 | C/T | — | uncertain significance |
| rs764174703 | 2:139,326,607 | G/A | — | uncertain significance |
| rs745359213 | 2:139,326,633 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.