SPOUT1
SPOUT domain containing methyltransferase 1
Summary
Enables miRNA binding activity. Involved in maintenance of centrosome location and miRNA processing. Acts upstream of with a positive effect on post-transcriptional regulation of gene expression. Located in kinetochore; mitotic spindle; and spindle pole centrosome. [provided by Alliance of Genome Resources, Apr 2025]
Known Variants31 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2280843 | 9:131,585,069 | A/G | — | benign |
| rs35677895 | 9:131,585,086 | G/C | — | benign |
| rs1260726352 | 9:131,585,105 | A/G | — | uncertain significance |
| rs2280842 | 9:131,585,808 | C/T | — | — |
| rs762384569 | 9:131,586,018 | G/A | — | likely benign |
| rs1018452459 | 9:131,586,030 | G/A | — | conflicting classifications of pathogenicity |
| rs374919043 | 9:131,586,034 | G/A | — | likely pathogenic |
| rs1830177315 | 9:131,586,060 | C/G | — | uncertain significance |
| rs1830177686 | 9:131,586,072 | T/C | — | likely pathogenic |
| rs756797528 | 9:131,586,148 | G/A | — | likely pathogenic |
| rs7033070 | 9:131,586,374 | G/A | — | benign |
| rs771013793 | 9:131,586,388 | C/T | — | likely pathogenic |
| rs1830188049 | 9:131,586,399 | G/A | — | uncertain significance |
| rs760043305 | 9:131,587,095 | C/G | — | uncertain significance |
| rs2490935545 | 9:131,587,131 | C/T | — | likely pathogenic |
| rs2293968 | 9:131,587,240 | G/A | downstream gene variant | — |
| rs149761259 | 9:131,588,342 | G/A | — | conflicting classifications of pathogenicity |
| rs751868247 | 9:131,588,350 | C/T | — | uncertain significance |
| rs776677726 | 9:131,588,406 | G/A | — | likely benign |
| rs117532426 | 9:131,588,658 | G/A | — | likely benign |
| rs6478853 | 9:131,588,813 | C/G | — | benign |
| rs73622710 | 9:131,588,859 | C/T | — | benign |
| rs6478854 | 9:131,588,888 | G/C | — | benign |
| rs370340839 | 9:131,589,313 | G/C | — | uncertain significance |
| rs771869476 | 9:131,589,387 | C/T | — | likely pathogenic |
| rs3817684 | 9:131,589,409 | C/T | — | benign |
| rs2490943302 | 9:131,589,416 | T/A | — | uncertain significance |
| rs1465223718 | 9:131,589,423 | T/C | — | uncertain significance |
| rs151128931 | 9:131,591,033 | C/T | — | likely benign |
| rs141898678 | 9:131,591,131 | C/T | — | likely benign |
| rs770160608 | 9:131,592,025 | G/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.