SPPL2C
signal peptide peptidase like 2C
Summary
Enables protein homodimerization activity. Predicted to be involved in several processes, including acrosome assembly; fusion of sperm to egg plasma membrane involved in single fertilization; and membrane protein intracellular domain proteolysis. Located in cytoplasmic side of endoplasmic reticulum membrane and lumenal side of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]
Known Variants83 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs151306798 | 17:43,922,300 | G/T | — | uncertain significance |
| rs776329351 | 17:43,922,315 | C/A | — | likely benign |
| rs758977730 | 17:43,922,318 | A/C | — | uncertain significance |
| rs1005321468 | 17:43,922,319 | T/G | — | uncertain significance |
| rs375094313 | 17:43,922,333 | G/A | — | likely benign |
| rs111852620 | 17:43,922,348 | G/A | — | uncertain significance |
| rs201940263 | 17:43,922,357 | G/A | — | uncertain significance |
| rs145837446 | 17:43,922,409 | A/G | — | likely benign |
| rs756952101 | 17:43,922,428 | C/A | — | uncertain significance |
| rs2544290299 | 17:43,922,459 | G/A | — | uncertain significance |
| rs117261590 | 17:43,922,474 | C/T | — | benign |
| rs2544290433 | 17:43,922,486 | G/C | — | uncertain significance |
| rs144539755 | 17:43,922,489 | G/A | — | uncertain significance |
| rs2074180 | 17:43,922,501 | C/T | — | benign |
| rs377400543 | 17:43,922,517 | G/A | — | uncertain significance |
| rs116482551 | 17:43,922,535 | C/T | — | benign |
| rs774466747 | 17:43,922,574 | G/A | — | uncertain significance |
| rs139470538 | 17:43,922,586 | C/T | — | uncertain significance |
| rs142777760 | 17:43,922,631 | T/C | — | uncertain significance |
| rs17763658 | 17:43,922,640 | G/A | — | benign |
| rs776433915 | 17:43,922,648 | G/A | — | uncertain significance |
| rs1318890953 | 17:43,922,667 | C/G | — | uncertain significance |
| rs140064060 | 17:43,922,672 | C/A | — | uncertain significance |
| rs149810017 | 17:43,922,681 | C/A | — | uncertain significance |
| rs2544291647 | 17:43,922,729 | C/G | — | uncertain significance |
| rs779287021 | 17:43,922,783 | G/A | — | uncertain significance |
| rs113793057 | 17:43,922,788 | C/T | — | benign |
| rs112690750 | 17:43,922,800 | C/T | — | benign |
| rs202087008 | 17:43,922,801 | G/A | — | uncertain significance |
| rs374408210 | 17:43,922,814 | C/A | — | uncertain significance |
| rs921865427 | 17:43,922,858 | G/A | — | uncertain significance |
| rs185853204 | 17:43,922,875 | C/T | — | benign |
| rs537220324 | 17:43,922,888 | G/A | — | uncertain significance |
| rs200550960 | 17:43,922,907 | G/A | — | uncertain significance |
| rs112870186 | 17:43,922,911 | A/G | — | likely benign |
| rs763285754 | 17:43,922,915 | C/T | — | uncertain significance |
| rs144845296 | 17:43,922,916 | G/A | — | uncertain significance |
| rs200783795 | 17:43,922,921 | C/T | — | uncertain significance |
| rs771564037 | 17:43,922,937 | G/C | — | uncertain significance |
| rs767879204 | 17:43,923,030 | C/T | — | uncertain significance |
| rs139341754 | 17:43,923,044 | G/T | — | uncertain significance |
| rs777587977 | 17:43,923,072 | T/G | — | uncertain significance |
| rs2062536500 | 17:43,923,117 | T/C | — | uncertain significance |
| rs2062536847 | 17:43,923,143 | A/T | — | uncertain significance |
| rs148824691 | 17:43,923,191 | C/T | — | likely benign |
| rs148362814 | 17:43,923,192 | G/A | — | likely benign |
| rs778425499 | 17:43,923,212 | C/A | — | uncertain significance |
| rs138704863 | 17:43,923,255 | C/T | — | uncertain significance |
| rs200843300 | 17:43,923,264 | G/T | — | benign |
| rs149355286 | 17:43,923,296 | C/T | — | uncertain significance |
| rs761698150 | 17:43,923,308 | C/T | — | uncertain significance |
| rs116972939 | 17:43,923,359 | G/A | — | uncertain significance |
| rs369336082 | 17:43,923,368 | C/T | — | uncertain significance |
| rs774363885 | 17:43,923,369 | G/A | — | uncertain significance |
| rs1273801590 | 17:43,923,375 | G/A | — | uncertain significance |
| rs148108168 | 17:43,923,381 | C/T | — | uncertain significance |
| rs150431364 | 17:43,923,410 | C/T | — | likely benign |
| rs1229216749 | 17:43,923,450 | C/A | — | uncertain significance |
| rs200714347 | 17:43,923,537 | T/G | — | uncertain significance |
| rs200992535 | 17:43,923,555 | G/A | — | uncertain significance |
| rs779090170 | 17:43,923,558 | T/G | — | uncertain significance |
| rs376781423 | 17:43,923,653 | C/T | — | uncertain significance |
| rs12185268 | 17:43,923,683 | A/T | missense variant | — |
| rs2062546274 | 17:43,923,707 | G/T | — | uncertain significance |
| rs2544295810 | 17:43,923,710 | T/C | — | uncertain significance |
| rs182470972 | 17:43,923,739 | G/A | — | uncertain significance |
| rs2544296349 | 17:43,923,842 | C/T | — | uncertain significance |
| rs192499150 | 17:43,923,884 | G/A | — | benign |
| rs1355344135 | 17:43,923,902 | G/A | — | uncertain significance |
| rs780398344 | 17:43,923,926 | G/A | — | uncertain significance |
| rs772418201 | 17:43,923,940 | C/A | — | uncertain significance |
| rs140899083 | 17:43,923,966 | C/G | — | uncertain significance |
| rs200780085 | 17:43,924,028 | A/G | — | uncertain significance |
| rs2544297233 | 17:43,924,053 | C/G | — | uncertain significance |
| rs990641394 | 17:43,924,127 | C/A | — | uncertain significance |
| rs142992698 | 17:43,924,151 | C/T | — | likely benign |
| rs12373142 | 17:43,924,200 | C/T | missense variant | — |
| rs12373124 | 17:43,924,219 | T/C | synonymous variant | — |
| rs200455227 | 17:43,924,243 | C/A | — | uncertain significance |
| rs114607012 | 17:43,924,254 | T/G | — | benign |
| rs2544298250 | 17:43,924,272 | A/C | — | uncertain significance |
| rs2544298259 | 17:43,924,274 | A/C | — | uncertain significance |
| rs144544474 | 17:43,924,292 | G/A | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.