SRA1
steroid receptor RNA activator 1
Summary
Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]
Known Variants59 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs76646635 | 5:139,930,307 | G/A | — | benign |
| rs2480850387 | 5:139,930,314 | T/C | — | uncertain significance |
| rs376107646 | 5:139,930,363 | C/G | — | uncertain significance |
| rs143729909 | 5:139,930,380 | T/C | — | likely benign |
| rs2480850688 | 5:139,930,388 | G/A | — | uncertain significance |
| rs201146083 | 5:139,930,396 | T/C | — | likely benign |
| rs747662579 | 5:139,930,446 | T/C | — | uncertain significance |
| rs773880085 | 5:139,930,454 | C/T | — | uncertain significance |
| rs148108594 | 5:139,930,460 | A/G | — | likely benign |
| rs116459403 | 5:139,930,474 | G/A | — | benign |
| rs373540673 | 5:139,930,626 | A/G | — | likely benign |
| rs149499620 | 5:139,930,696 | C/T | — | likely benign |
| rs201620894 | 5:139,930,704 | C/A | — | uncertain significance |
| rs745637128 | 5:139,930,705 | T/G | — | uncertain significance |
| rs142293594 | 5:139,930,726 | C/T | — | conflicting classifications of pathogenicity |
| rs200617902 | 5:139,930,736 | T/C | — | uncertain significance |
| rs748152502 | 5:139,931,571 | G/T | — | uncertain significance |
| rs1306465994 | 5:139,931,580 | C/T | — | uncertain significance |
| rs115569414 | 5:139,931,607 | G/A | — | likely benign |
| rs202193903 | 5:139,931,629 | C/G | — | benign |
| rs147164252 | 5:139,931,642 | G/A | — | likely benign |
| rs140584772 | 5:139,931,652 | C/G | — | uncertain significance |
| rs2480854196 | 5:139,931,683 | T/G | — | uncertain significance |
| rs1353301917 | 5:139,931,687 | C/A | — | likely benign |
| rs148259347 | 5:139,931,691 | G/A | — | likely benign |
| rs1754581092 | 5:139,931,725 | G/T | — | uncertain significance |
| rs572629756 | 5:139,931,727 | G/C | — | uncertain significance |
| rs375519604 | 5:139,931,737 | G/C | — | uncertain significance |
| rs542845030 | 5:139,931,738 | G/C | — | benign |
| rs141327120 | 5:139,931,739 | G/A | — | benign |
| rs143611190 | 5:139,931,740 | G/A | — | uncertain significance |
| rs1369640192 | 5:139,931,758 | C/G | — | uncertain significance |
| rs146775907 | 5:139,931,764 | C/T | — | likely benign |
| rs10589076 | 5:139,931,779 | T/A | — | benign |
| rs801460 | 5:139,931,930 | C/T | downstream gene variant | benign |
| rs10463297 | 5:139,936,239 | T/G | — | — |
| rs367845985 | 5:139,936,725 | C/T | — | likely benign |
| rs751585477 | 5:139,936,748 | C/A | — | uncertain significance |
| rs767704820 | 5:139,936,749 | T/A | — | uncertain significance |
| rs142846017 | 5:139,936,755 | G/A | — | uncertain significance |
| rs754245638 | 5:139,936,757 | G/C | — | likely benign |
| rs250426 | 5:139,936,760 | G/A | synonymous variant | benign |
| rs770758695 | 5:139,936,792 | C/T | — | uncertain significance |
| rs2480864035 | 5:139,936,799 | C/T | — | likely benign |
| rs534062987 | 5:139,936,818 | G/A | — | uncertain significance |
| rs35610885 | 5:139,936,825 | G/C | — | benign |
| rs769323986 | 5:139,936,830 | G/C | — | uncertain significance |
| rs34009206 | 5:139,936,835 | G/A | — | benign |
| rs760877862 | 5:139,936,855 | T/C | — | uncertain significance |
| rs200718775 | 5:139,936,868 | G/A | — | likely benign |
| rs35999684 | 5:139,936,921 | G/A | — | likely benign |
| rs250427 | 5:139,936,980 | A/G | — | benign |
| rs779779481 | 5:139,937,004 | T/C | — | likely benign |
| rs781046195 | 5:139,937,010 | C/G | — | uncertain significance |
| rs771291291 | 5:139,937,015 | G/A | — | uncertain significance |
| rs1028067850 | 5:139,937,055 | C/T | — | uncertain significance |
| rs527598254 | 5:139,937,063 | C/T | — | uncertain significance |
| rs890835036 | 5:139,937,069 | G/C | — | uncertain significance |
| rs201105057 | 5:139,937,079 | G/C | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.