SSH2
slingshot protein phosphatase 2
Summary
This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Known Variants82 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs76770670 | 17:27,957,868 | A/G | — | benign |
| rs2508248723 | 17:27,957,894 | T/C | — | uncertain significance |
| rs761793558 | 17:27,958,011 | C/T | — | likely benign |
| rs531618802 | 17:27,958,079 | C/T | — | uncertain significance |
| rs74561982 | 17:27,958,197 | C/T | — | benign |
| rs533970239 | 17:27,958,230 | C/T | — | uncertain significance |
| rs2508257839 | 17:27,958,270 | T/A | — | uncertain significance |
| rs2508259441 | 17:27,958,337 | T/C | — | uncertain significance |
| rs557542995 | 17:27,958,350 | C/T | — | uncertain significance |
| rs754211061 | 17:27,958,364 | C/T | — | uncertain significance |
| rs137889063 | 17:27,958,365 | G/A | — | uncertain significance |
| rs745762993 | 17:27,958,416 | C/T | — | uncertain significance |
| rs749077183 | 17:27,958,428 | C/A | — | uncertain significance |
| rs374647405 | 17:27,958,446 | C/T | — | likely benign |
| rs200166314 | 17:27,958,506 | C/T | — | uncertain significance |
| rs148361183 | 17:27,958,562 | C/T | — | uncertain significance |
| rs770176053 | 17:27,958,631 | G/C | — | uncertain significance |
| rs2508267201 | 17:27,958,691 | C/T | — | uncertain significance |
| rs61737984 | 17:27,958,790 | G/C | — | benign |
| rs763929129 | 17:27,958,809 | A/G | — | uncertain significance |
| rs2508270253 | 17:27,958,812 | G/C | — | uncertain significance |
| rs150623233 | 17:27,958,851 | T/A | — | uncertain significance |
| rs1253173023 | 17:27,958,881 | G/A | — | uncertain significance |
| rs2508272242 | 17:27,958,901 | G/T | — | uncertain significance |
| rs140564325 | 17:27,958,931 | T/C | — | uncertain significance |
| rs1567824693 | 17:27,958,973 | A/T | — | uncertain significance |
| rs2508276091 | 17:27,959,064 | G/C | — | uncertain significance |
| rs369139548 | 17:27,959,066 | T/C | — | uncertain significance |
| rs2508276308 | 17:27,959,069 | G/A | — | uncertain significance |
| rs143486431 | 17:27,959,130 | C/A | — | uncertain significance |
| rs150943462 | 17:27,959,136 | G/C | — | uncertain significance |
| rs200804844 | 17:27,959,171 | A/C | — | uncertain significance |
| rs2508281331 | 17:27,959,310 | C/T | — | uncertain significance |
| rs376316249 | 17:27,959,375 | G/T | — | uncertain significance |
| rs1488403020 | 17:27,959,396 | C/T | — | uncertain significance |
| rs140701084 | 17:27,959,430 | T/G | — | uncertain significance |
| rs145810496 | 17:27,959,444 | C/T | — | uncertain significance |
| rs138401180 | 17:27,959,480 | T/C | — | uncertain significance |
| rs149601529 | 17:27,959,544 | G/A | — | uncertain significance |
| rs148314998 | 17:27,959,699 | G/C | — | uncertain significance |
| rs200437711 | 17:27,959,719 | C/A | — | uncertain significance |
| rs2035739961 | 17:27,959,753 | G/A | — | uncertain significance |
| rs61127551 | 17:27,962,574 | C/A | — | — |
| rs149046530 | 17:27,963,057 | G/T | — | uncertain significance |
| rs140734654 | 17:27,963,104 | C/T | — | uncertain significance |
| rs762841103 | 17:27,963,161 | C/T | — | uncertain significance |
| rs138448323 | 17:27,963,197 | T/C | — | uncertain significance |
| rs200774360 | 17:27,963,235 | A/C | — | uncertain significance |
| rs774081332 | 17:27,963,301 | G/T | — | uncertain significance |
| rs2508342624 | 17:27,963,345 | C/T | — | uncertain significance |
| rs201366205 | 17:27,963,431 | G/C | — | uncertain significance |
| rs747900825 | 17:27,963,455 | T/C | — | uncertain significance |
| rs138829419 | 17:27,963,512 | T/C | — | uncertain significance |
| rs200751319 | 17:27,963,651 | C/G | — | uncertain significance |
| rs532107609 | 17:27,963,678 | T/A | — | uncertain significance |
| rs2508351037 | 17:27,963,741 | C/T | — | uncertain significance |
| rs752198300 | 17:27,963,766 | G/C | — | uncertain significance |
| rs748727968 | 17:27,975,238 | C/T | — | uncertain significance |
| rs1808923 | 17:27,980,885 | C/T | intron variant | — |
| rs183790295 | 17:27,993,083 | G/A | intron variant | — |
| rs371966725 | 17:27,998,985 | G/C | — | uncertain significance |
| rs112212550 | 17:27,999,018 | A/G | — | benign |
| rs1598765180 | 17:27,999,100 | T/C | — | uncertain significance |
| rs759004141 | 17:27,999,103 | G/A | — | uncertain significance |
| rs753974397 | 17:28,004,746 | T/C | — | uncertain significance |
| rs1377579160 | 17:28,011,612 | C/T | — | uncertain significance |
| rs772807575 | 17:28,011,671 | C/T | — | uncertain significance |
| rs2508673263 | 17:28,011,693 | G/T | — | uncertain significance |
| rs752108275 | 17:28,022,499 | C/A | — | uncertain significance |
| rs1218847045 | 17:28,022,530 | G/C | — | uncertain significance |
| rs7210152 | 17:28,065,279 | T/C | intron variant | — |
| rs4474742 | 17:28,065,578 | A/C | — | — |
| rs548640283 | 17:28,068,952 | C/T | — | — |
| rs2729450 | 17:28,088,459 | T/C | regulatory region variant | — |
| rs2259855 | 17:28,097,860 | T/C | downstream gene variant | — |
| rs2250320 | 17:28,128,657 | G/A | — | — |
| rs76515799 | 17:28,169,491 | A/G | intron variant | — |
| rs28715670 | 17:28,222,758 | A/C | — | — |
| rs370500262 | 17:28,226,075 | A/G | — | — |
| rs75204514 | 17:28,226,832 | A/T | — | — |
| rs7210288 | 17:28,243,473 | T/C | — | — |
| rs369609551 | 17:28,256,984 | G/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.