STARD13

StAR related lipid transfer domain containing 13

Summary

This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Known Variants99 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs1410181274	13:33,679,798	C/T	—	uncertain significance
rs642899	13:33,680,854	T/G	intron variant	—
rs201738034	13:33,680,904	A/G	—	uncertain significance
rs117237914	13:33,680,945	C/T	—	likely benign
rs754069436	13:33,680,961	T/C	—	uncertain significance
rs370325874	13:33,680,976	A/T	—	likely benign
rs780935209	13:33,680,999	C/G	—	uncertain significance
rs671937	13:33,682,737	C/T	regulatory region variant	—
rs144058395	13:33,684,025	T/G	—	uncertain significance
rs114645645	13:33,684,035	G/A	—	likely benign
rs200778829	13:33,684,038	G/A	—	uncertain significance
rs377530803	13:33,684,040	G/A	—	uncertain significance
rs528268102	13:33,684,082	C/T	—	likely benign
rs745944885	13:33,684,089	G/C	—	uncertain significance
rs267603806	13:33,684,122	C/T	—	uncertain significance
rs760209242	13:33,684,136	C/T	—	uncertain significance
rs34251901	13:33,684,168	G/A	—	benign
rs35364312	13:33,684,862	C/T	—	benign
rs537417836	13:33,684,890	G/A	—	uncertain significance
rs771015540	13:33,686,861	G/A	—	uncertain significance
rs764691713	13:33,686,927	A/G	—	uncertain significance
rs775002742	13:33,686,931	G/A	—	uncertain significance
rs144923151	13:33,686,967	C/G	—	uncertain significance
rs150898613	13:33,687,040	G/A	—	benign
rs1392547164	13:33,687,057	C/G	—	uncertain significance
rs36090640	13:33,691,171	T/A	intron variant	—
rs765661702	13:33,692,264	C/T	—	uncertain significance
rs148278209	13:33,692,288	G/A	—	uncertain significance
rs771045790	13:33,692,388	G/A	—	uncertain significance
rs9315204	13:33,693,837	C/T	regulatory region variant	—
rs1944321157	13:33,700,315	C/G	—	uncertain significance
rs537868889	13:33,700,360	A/G	—	uncertain significance
rs2500475576	13:33,700,370	G/A	—	uncertain significance
rs1275205577	13:33,701,558	G/A	—	uncertain significance
rs374603701	13:33,701,565	G/A	—	uncertain significance
rs201808755	13:33,701,586	G/A	—	uncertain significance
rs1877360417	13:33,701,588	A/G	—	uncertain significance
rs148556189	13:33,701,639	G/C	—	uncertain significance
rs374265748	13:33,701,643	G/A	—	uncertain significance
rs1448091747	13:33,701,673	A/G	—	uncertain significance
rs766080799	13:33,701,675	C/T	—	uncertain significance
rs944961449	13:33,701,681	C/T	—	uncertain significance
rs750509304	13:33,703,139	T/C	—	uncertain significance
rs201883988	13:33,703,180	C/T	—	uncertain significance
rs758941461	13:33,703,181	G/A	—	uncertain significance
rs1409283734	13:33,703,190	A/C	—	uncertain significance
rs770451366	13:33,703,220	T/C	—	uncertain significance
rs533317708	13:33,703,234	G/A	—	uncertain significance
rs375856181	13:33,703,237	A/G	—	uncertain significance
rs41306650	13:33,703,240	G/A	—	uncertain significance
rs150961010	13:33,703,282	A/G	—	uncertain significance
rs748012311	13:33,703,409	C/A	—	uncertain significance
rs149018354	13:33,703,470	C/T	—	likely benign
rs34981374	13:33,703,472	C/T	—	uncertain significance
rs142351638	13:33,703,481	G/A	—	uncertain significance
rs1877820958	13:33,703,501	A/G	—	uncertain significance
rs35988623	13:33,703,539	A/G	—	benign
rs750388909	13:33,703,668	G/T	—	uncertain significance
rs142906014	13:33,703,698	C/A	—	benign
rs762560069	13:33,703,701	C/T	—	likely benign
rs142522333	13:33,703,702	G/A	—	likely benign
rs200449699	13:33,703,738	C/T	—	uncertain significance
rs146699264	13:33,703,752	G/A	—	benign
rs751650663	13:33,703,802	G/T	—	likely benign
rs781572832	13:33,703,807	G/A	—	uncertain significance
rs1290656660	13:33,703,810	G/A	—	uncertain significance
rs1455727911	13:33,703,825	C/T	—	uncertain significance
rs2500514211	13:33,703,945	A/G	—	uncertain significance
rs1324828334	13:33,703,987	T/C	—	uncertain significance
rs145202504	13:33,704,030	G/A	—	uncertain significance
rs148927890	13:33,704,064	C/T	—	likely benign
rs3742321	13:33,704,065	T/C	missense variant	—
rs2500516325	13:33,704,080	T/C	—	uncertain significance
rs144921083	13:33,704,118	G/A	—	likely benign
rs199932998	13:33,704,155	G/A	—	uncertain significance
rs532975709	13:33,704,192	T/A	—	uncertain significance
rs1593913972	13:33,704,212	T/C	—	uncertain significance
rs149234861	13:33,704,275	G/A	—	uncertain significance
rs111691119	13:33,704,319	T/A	—	benign
rs779118474	13:33,704,332	G/A	—	uncertain significance
rs2500521007	13:33,704,345	C/A	—	uncertain significance
rs114088950	13:33,704,346	C/T	—	benign
rs142245407	13:33,704,348	C/T	—	likely benign
rs778960009	13:33,704,406	T/A	—	uncertain significance
rs758596770	13:33,704,414	C/T	—	uncertain significance
rs2296394	13:33,741,692	A/G	—	benign
rs182226781	13:33,747,121	G/A	regulatory region variant	—
rs2555603	13:33,798,262	A/C	intron variant	—
rs370033941	13:33,859,634	G/T	—	uncertain significance
rs1892012598	13:33,859,670	G/A	—	uncertain significance
rs199767190	13:33,859,699	A/G	—	uncertain significance
rs769437825	13:33,859,705	T/C	—	uncertain significance
rs762704042	13:33,859,720	A/G	—	uncertain significance
rs774186136	13:33,859,729	A/T	—	uncertain significance
rs9537521	13:34,038,180	G/A	intron variant	—
rs182096803	13:34,098,058	T/C	intron variant	—
rs75920313	13:34,177,277	T/C	intron variant	—
rs8001893	13:34,222,261	C/A	intron variant	—
rs191636226	13:34,233,008	C/A	intron variant	—

Gene information from NCBI Gene. Variant classifications from ClinVar.