STK10
serine/threonine kinase 10
Summary
This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]
Known Variants69 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1767466161 | 5:171,471,948 | T/C | — | uncertain significance |
| rs56355550 | 5:171,471,953 | C/T | — | uncertain significance |
| rs759646603 | 5:171,479,941 | G/A | — | uncertain significance |
| rs1238071413 | 5:171,479,942 | C/T | — | likely benign |
| rs1767664353 | 5:171,480,004 | G/C | — | uncertain significance |
| rs113551500 | 5:171,481,567 | C/G | — | benign |
| rs2480347905 | 5:171,481,607 | C/A | — | uncertain significance |
| rs754651618 | 5:171,481,662 | G/A | — | uncertain significance |
| rs1767731379 | 5:171,482,609 | G/A | — | uncertain significance |
| rs777699775 | 5:171,482,639 | T/C | — | uncertain significance |
| rs746182921 | 5:171,482,660 | T/G | — | uncertain significance |
| rs1393603165 | 5:171,482,683 | C/T | — | uncertain significance |
| rs756323576 | 5:171,482,705 | G/A | — | uncertain significance |
| rs1290761615 | 5:171,484,441 | T/G | — | uncertain significance |
| rs138305428 | 5:171,484,475 | G/A | — | uncertain significance |
| rs763255823 | 5:171,488,145 | C/T | — | uncertain significance |
| rs201995192 | 5:171,488,199 | C/T | — | uncertain significance |
| rs370433044 | 5:171,488,269 | G/A | — | uncertain significance |
| rs751088982 | 5:171,491,737 | T/C | — | uncertain significance |
| rs367724546 | 5:171,491,756 | T/C | — | uncertain significance |
| rs770403355 | 5:171,491,792 | G/A | — | uncertain significance |
| rs371455341 | 5:171,491,807 | C/T | — | uncertain significance |
| rs771916616 | 5:171,509,341 | T/C | — | uncertain significance |
| rs563669946 | 5:171,509,429 | G/C | — | uncertain significance |
| rs150715921 | 5:171,509,440 | T/A | — | uncertain significance |
| rs576346631 | 5:171,509,987 | T/A | — | uncertain significance |
| rs1768469460 | 5:171,510,023 | C/T | — | uncertain significance |
| rs183006793 | 5:171,512,271 | C/T | upstream gene variant | — |
| rs1276835691 | 5:171,517,318 | C/A | — | uncertain significance |
| rs746850981 | 5:171,517,326 | T/C | — | uncertain significance |
| rs17074311 | 5:171,517,362 | G/A | — | benign |
| rs761341472 | 5:171,520,419 | G/T | — | likely benign |
| rs375474266 | 5:171,520,486 | C/G | — | uncertain significance |
| rs563239491 | 5:171,520,604 | C/T | — | uncertain significance |
| rs199527490 | 5:171,520,654 | G/A | — | uncertain significance |
| rs756649588 | 5:171,520,709 | T/C | — | uncertain significance |
| rs778247621 | 5:171,520,711 | G/C | — | uncertain significance |
| rs375820809 | 5:171,520,724 | C/T | — | uncertain significance |
| rs114771940 | 5:171,520,790 | G/C | — | benign |
| rs779604842 | 5:171,520,876 | G/C | — | uncertain significance |
| rs2532247758 | 5:171,520,889 | A/T | — | uncertain significance |
| rs552941936 | 5:171,520,895 | C/T | — | likely benign |
| rs55972616 | 5:171,520,963 | G/A | — | uncertain significance |
| rs935708460 | 5:171,523,459 | C/G | — | uncertain significance |
| rs56214442 | 5:171,523,471 | G/A | — | uncertain significance |
| rs573760781 | 5:171,523,474 | C/T | — | uncertain significance |
| rs146021633 | 5:171,523,548 | C/T | — | uncertain significance |
| rs545019190 | 5:171,523,560 | G/T | — | uncertain significance |
| rs202191993 | 5:171,532,679 | C/G | — | uncertain significance |
| rs142144816 | 5:171,532,727 | C/T | — | uncertain significance |
| rs150004028 | 5:171,533,653 | G/C | — | uncertain significance |
| rs201487887 | 5:171,533,739 | T/C | — | uncertain significance |
| rs201303206 | 5:171,534,790 | G/A | — | uncertain significance |
| rs372811283 | 5:171,534,797 | C/T | — | uncertain significance |
| rs142301756 | 5:171,544,510 | C/T | — | uncertain significance |
| rs6895573 | 5:171,544,519 | G/A | — | benign |
| rs374495662 | 5:171,544,589 | C/A | — | uncertain significance |
| rs62641682 | 5:171,554,390 | G/T | — | uncertain significance |
| rs149323437 | 5:171,554,395 | C/T | — | uncertain significance |
| rs62641681 | 5:171,554,396 | G/A | — | benign |
| rs17570583 | 5:171,559,531 | G/A | intron variant | — |
| rs6899139 | 5:171,571,511 | T/A | regulatory region variant | — |
| rs545299824 | 5:171,582,988 | G/A | — | — |
| rs377315172 | 5:171,583,644 | T/C | — | uncertain significance |
| rs143554311 | 5:171,584,615 | G/A | intron variant | — |
| rs1220019694 | 5:171,614,948 | G/C | — | uncertain significance |
| rs749870859 | 5:171,614,949 | T/C | — | uncertain significance |
| rs147874779 | 5:171,614,971 | C/T | — | uncertain significance |
| rs115420947 | 5:171,615,015 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.