STK3
serine/threonine kinase 3
Summary
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Known Variants22 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs28731215 | 8:99,373,367 | A/G | intergenic variant | — |
| rs2488743895 | 8:99,468,077 | T/C | — | uncertain significance |
| rs1273771278 | 8:99,539,005 | T/A | — | uncertain significance |
| rs776939644 | 8:99,539,006 | A/T | — | uncertain significance |
| rs36047674 | 8:99,539,034 | A/C | — | uncertain significance |
| rs369763923 | 8:99,539,045 | C/A | — | uncertain significance |
| rs749145486 | 8:99,539,053 | G/T | — | uncertain significance |
| rs2489181972 | 8:99,560,214 | T/C | — | uncertain significance |
| rs377506715 | 8:99,560,286 | A/G | — | uncertain significance |
| rs908567268 | 8:99,560,290 | T/C | — | uncertain significance |
| rs759167472 | 8:99,591,893 | G/A | — | uncertain significance |
| rs1317615834 | 8:99,591,934 | A/C | — | uncertain significance |
| rs747423317 | 8:99,591,938 | C/T | — | uncertain significance |
| rs749218138 | 8:99,591,983 | A/G | — | uncertain significance |
| rs1563760718 | 8:99,591,987 | A/G | — | uncertain significance |
| rs1338762257 | 8:99,608,337 | C/T | — | uncertain significance |
| rs147740707 | 8:99,668,210 | T/C | intron variant | — |
| rs182029202 | 8:99,683,879 | G/A | intron variant | — |
| rs1424205963 | 8:99,718,739 | T/C | — | uncertain significance |
| rs575295558 | 8:99,719,473 | T/C | — | uncertain significance |
| rs3019286 | 8:99,895,405 | G/A | regulatory region variant | — |
| rs111660868 | 8:99,919,392 | A/C | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.