STK4

serine/threonine kinase 4

Summary

The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]

Known Variants232 total

rsidPosition (GRCh37)AllelesClassClinVar
rs19092031520:43,595,208C/G—likely benign
rs120344346020:43,595,238C/T—uncertain significance
rs75666230820:43,595,252G/T—likely benign
rs481044620:43,595,868T/A—benign
rs14770255320:43,597,236G/Aupstream gene variant—
rs6765181420:43,598,154G/Cupstream gene variant—
rs18248714820:43,599,981T/Aregulatory region variant—
rs613071720:43,600,673C/G—benign
rs76934177520:43,600,701A/G—likely benign
rs11281206920:43,600,707C/G—benign
rs145673930620:43,600,715A/G—likely benign
rs76618582520:43,600,716C/T—uncertain significance
rs251558699920:43,600,718G/A—likely pathogenic
rs136581991720:43,600,721A/C—uncertain significance
rs75976021920:43,600,728A/G—likely benign
rs14259480220:43,600,730A/G—uncertain significance
rs135183822220:43,600,737T/C—likely benign
rs37320511720:43,600,761A/G—likely benign
rs78077435320:43,600,790T/C—uncertain significance
rs95020534820:43,600,809A/G—likely benign
rs11343583820:43,600,819A/G—likely benign
rs91067120:43,601,921G/T—benign
rs601745220:43,604,003C/Tintron variantbenign
rs251559886520:43,607,077T/C—likely benign
rs75096106020:43,607,087C/G—likely benign
rs15011156920:43,607,096C/T—likely benign
rs206737766520:43,607,120G/A—likely benign
rs206737772620:43,607,122C/T—uncertain significance
rs77715428920:43,607,123C/T—likely benign
rs251559906420:43,607,125G/A—uncertain significance
rs146479605720:43,607,126C/A—likely benign
rs251559932320:43,607,229T/G—likely benign
rs37064733320:43,610,451A/G—likely benign
rs18922950020:43,610,458C/T—likely benign
rs75573728820:43,610,460C/T—likely benign
rs130100004620:43,610,466C/G—likely benign
rs36863149520:43,610,470C/T—conflicting classifications of pathogenicity
rs77837490020:43,610,484A/G—uncertain significance
rs132126203020:43,610,488T/C—likely benign
rs214565296120:43,610,500T/C—likely benign
rs123691526320:43,610,512A/G—likely benign
rs76832818220:43,610,515C/A—likely benign
rs13805294820:43,610,524C/T—likely benign
rs37554394620:43,610,525G/A—uncertain significance
rs76337629820:43,610,526T/C—uncertain significance
rs143558979420:43,610,529T/C—uncertain significance
rs251560490520:43,610,551T/G—likely benign
rs214565323420:43,610,564A/G—uncertain significance
rs38790731620:43,610,573C/Tstop gainedpathogenic
rs20204081920:43,610,574G/A—likely benign
rs214565329720:43,610,578T/C—likely benign
rs251560500320:43,610,580A/C—uncertain significance
rs36851399020:43,610,583C/T—uncertain significance
rs75685825520:43,610,600A/G—likely benign
rs251561360920:43,615,757C/G—likely benign
rs76315333020:43,615,759T/A—likely benign
rs206754274320:43,615,768T/C—likely benign
rs77496285920:43,615,778A/G—likely benign
rs75994208920:43,615,782G/T—uncertain significance
rs214566530520:43,615,785G/T—pathogenic
rs37133257520:43,615,799A/G—uncertain significance
rs75153750720:43,615,806T/G—uncertain significance
rs251561384820:43,615,807C/A—likely pathogenic
rs78113767120:43,615,809A/G—uncertain significance
rs76970100420:43,615,832T/C—likely benign
rs251561398320:43,615,836T/C—uncertain significance
rs206754452320:43,615,839A/T—uncertain significance
rs74944122620:43,615,854C/T—pathogenic
rs95935102420:43,615,877T/A—likely benign
rs77425082620:43,615,885A/G—uncertain significance
rs5585075920:43,615,896C/A—conflicting classifications of pathogenicity
rs76109129920:43,615,919G/A—likely benign
rs206754654520:43,615,930A/T—uncertain significance
rs76246352020:43,615,931A/G—likely benign
rs251561440820:43,615,936C/T—uncertain significance
rs18936034620:43,615,951T/C—likely benign
rs96119202620:43,615,953A/C—likely benign
rs1190801120:43,617,226C/T——
rs601746020:43,623,658C/T—benign
rs130454437220:43,623,718C/G—likely benign
rs7466379320:43,623,722C/G—benign
rs52830136020:43,623,724A/G—likely benign
rs251562779620:43,623,736C/T—likely benign
rs77682069320:43,623,754A/G—likely benign
rs251562790020:43,623,762G/A—uncertain significance
rs251562792020:43,623,768C/T—uncertain significance
rs131261695220:43,623,791A/G—uncertain significance
rs76588799020:43,623,797G/C—uncertain significance
rs214568353820:43,623,804G/A—uncertain significance
rs75918562720:43,623,805A/T—likely benign
rs37773347420:43,623,824A/G—uncertain significance
rs214568366320:43,623,847C/T—likely benign
rs214568370020:43,623,867A/G—uncertain significance
rs140601153220:43,623,868G/T—uncertain significance
rs13931038020:43,623,871C/T—likely benign
rs75851867620:43,623,909G/A—likely benign
rs206770739620:43,623,912C/G—likely benign
rs92218595920:43,625,806C/G—uncertain significance
rs206774654920:43,625,819A/G—uncertain significance
rs75066180320:43,625,829C/G—uncertain significance

Showing 100 of 232 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.