SUOX

sulfite oxidase

Summary

Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine. Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age. Alternative splicing results in multiple transcript variants encoding identical proteins. [provided by RefSeq, Jul 2008]

Known Variants390 total

rsidPosition (GRCh37)AllelesClassClinVar
rs14331509012:56,391,043A/T—likely benign
rs88604967812:56,391,047C/T—uncertain significance
rs135249562412:56,391,114A/G—uncertain significance
rs11441029012:56,391,411C/T—benign
rs77365049412:56,391,433G/A—uncertain significance
rs88604967912:56,391,460C/A—uncertain significance
rs70570312:56,391,486T/C—benign
rs88604968012:56,391,493G/C—uncertain significance
rs14278839112:56,392,489A/Cdownstream gene variant—
rs53406639712:56,393,111T/G—likely benign
rs13917010312:56,393,120C/T—likely benign
rs88604968112:56,393,179T/A—uncertain significance
rs37334177812:56,393,230G/A—uncertain significance
rs77312512:56,394,954A/Gupstream gene variant—
rs729766212:56,395,378G/Aregulatory region variant—
rs37536394312:56,396,024G/A—conflicting classifications of pathogenicity
rs53772052612:56,396,028T/C—uncertain significance
rs77907952412:56,396,029G/A—likely benign
rs254057366812:56,396,034T/C—uncertain significance
rs189055878712:56,396,042C/T—pathogenic
rs213650911712:56,396,044A/G—likely benign
rs132603355612:56,396,045C/A—uncertain significance
rs139597543812:56,396,047G/A—likely benign
rs129338967712:56,396,060G/A—uncertain significance
rs36832799112:56,396,064G/A—conflicting classifications of pathogenicity
rs74934277612:56,396,068A/G—likely benign
rs130526647912:56,396,070C/T—likely benign
rs76865345712:56,396,073A/G—likely benign
rs213650915812:56,396,075G/C—likely benign
rs189057008212:56,396,310A/G—likely benign
rs189057020912:56,396,311C/T—likely benign
rs76783841712:56,396,312C/A—likely benign
rs14143225512:56,396,313G/A—conflicting classifications of pathogenicity
rs189057052812:56,396,317T/A—uncertain significance
rs74948035312:56,396,320C/T—likely benign
rs127376826812:56,396,325A/C—likely pathogenic
rs75506806212:56,396,337A/G—uncertain significance
rs254057412112:56,396,348G/A—likely benign
rs254057414412:56,396,357T/C—likely benign
rs189057284812:56,396,363C/T—likely benign
rs141954052112:56,396,365G/C—uncertain significance
rs213650961612:56,396,366C/A—pathogenic
rs213650964612:56,396,371C/T—uncertain significance
rs117511747512:56,396,391C/T—pathogenic
rs75916897012:56,396,394C/T—uncertain significance
rs11777887012:56,396,395G/A—likely benign
rs121139754312:56,396,416G/A—uncertain significance
rs75096231012:56,396,423C/T—likely benign
rs189057613512:56,396,426C/T—likely benign
rs121772653812:56,396,429C/T—likely benign
rs37738866612:56,396,432C/G—likely benign
rs75408238312:56,396,435G/A—likely benign
rs213650976712:56,396,436G/A—uncertain significance
rs75519176412:56,396,437G/A—uncertain significance
rs254057429912:56,396,438A/G—likely benign
rs159282688512:56,396,453G/C—likely benign
rs75857979612:56,396,455C/T—uncertain significance
rs134717976012:56,396,462A/T—uncertain significance
rs18885367312:56,396,463G/A—likely benign
rs57736077112:56,396,468C/T—conflicting classifications of pathogenicity
rs77083719612:56,396,469G/A—uncertain significance
rs254057437112:56,396,470G/A—uncertain significance
rs189057872312:56,396,475G/C—uncertain significance
rs134252956612:56,396,492C/T—likely benign
rs14935706612:56,396,494A/G—uncertain significance
rs54158981512:56,396,496C/T—uncertain significance
rs20183007112:56,396,497G/A—uncertain significance
rs20208514512:56,396,504G/Tmissense variantpathogenic
rs77365528612:56,396,505G/A—pathogenic
rs79693780312:56,396,513G/C—likely benign
rs189058088812:56,396,516A/G—likely benign
rs213650989812:56,396,517A/C—likely benign
rs254057448212:56,396,520G/A—likely benign
rs170288112:56,396,772A/G—benign
rs189061139412:56,397,384C/T—likely benign
rs75742459512:56,397,386C/T—likely benign
rs76728938012:56,397,387C/T—likely benign
rs37757306612:56,397,388T/C—likely benign
rs75581305512:56,397,389T/C—likely benign
rs254057551512:56,397,391C/T—likely benign
rs254057552012:56,397,397A/G—likely benign
rs98894849512:56,397,410G/C—uncertain significance
rs128144281812:56,397,413G/A—likely benign
rs76157214712:56,397,419A/C—likely benign
rs14369278012:56,397,420C/A—uncertain significance
rs96634302512:56,397,421A/C—uncertain significance
rs189061438012:56,397,422C/T—likely benign
rs77695599112:56,397,423A/G—uncertain significance
rs74643666812:56,397,426T/C—uncertain significance
rs77002417812:56,397,428C/T—likely benign
rs144755187112:56,397,441G/C—uncertain significance
rs37633865412:56,397,443G/C—likely benign
rs76325368312:56,397,452C/T—conflicting classifications of pathogenicity
rs189061609912:56,397,453A/G—uncertain significance
rs124063348612:56,397,455C/G—likely benign
rs76435236312:56,397,461T/C—likely benign
rs189061708212:56,397,467T/C—likely benign
rs14811651512:56,397,468G/A—uncertain significance
rs76607799212:56,397,473C/T—likely benign
rs86721053812:56,397,475G/A—pathogenic

Showing 100 of 390 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.