SURF4
surfeit 4
Summary
This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Known Variants24 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs587631689 | 9:136,228,940 | G/A | — | — |
| rs976905697 | 9:136,230,395 | T/C | — | uncertain significance |
| rs1319378203 | 9:136,230,506 | T/C | — | uncertain significance |
| rs782764743 | 9:136,230,520 | T/C | — | uncertain significance |
| rs782795084 | 9:136,231,723 | A/C | — | uncertain significance |
| rs781900544 | 9:136,231,730 | C/T | — | uncertain significance |
| rs1309048890 | 9:136,231,747 | G/A | — | uncertain significance |
| rs148945883 | 9:136,231,826 | C/T | — | uncertain significance |
| rs878915690 | 9:136,231,855 | C/T | — | uncertain significance |
| rs587601968 | 9:136,232,535 | C/A | — | — |
| rs782121143 | 9:136,232,880 | C/T | — | uncertain significance |
| rs782677808 | 9:136,234,186 | C/T | — | uncertain significance |
| rs199692147 | 9:136,234,224 | C/A | — | uncertain significance |
| rs782238598 | 9:136,234,314 | C/A | — | uncertain significance |
| rs181190300 | 9:136,234,315 | G/A | — | uncertain significance |
| rs191721403 | 9:136,238,250 | C/A | regulatory region variant | — |
| rs183864830 | 9:136,238,254 | G/A | regulatory region variant | — |
| rs189034018 | 9:136,238,326 | A/G | regulatory region variant | — |
| rs185339843 | 9:136,239,453 | T/G | upstream gene variant | — |
| rs138030509 | 9:136,239,539 | T/G | upstream gene variant | — |
| rs192308651 | 9:136,241,489 | C/A | upstream gene variant | — |
| rs76908219 | 9:136,242,766 | G/A | regulatory region variant | — |
| rs1285527695 | 9:136,242,833 | T/C | — | uncertain significance |
| rs3739893 | 9:136,243,324 | C/T | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.