SYCP2

synaptonemal complex protein 2

Summary

The synaptonemal complex is a proteinaceous structure that links homologous chromosomes during the prophase of meiosis. The protein encoded by this gene is a major component of the synaptonemal complex and may bind DNA at scaffold attachment regions. The encoded protein requires synaptonemal complex protein 3, but not 1, for inclusion in the synaptonemal complex. [provided by RefSeq, Jul 2008]

Known Variants91 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs768892525	20:58,439,391	G/A	—	uncertain significance
rs781559155	20:58,439,395	T/C	—	uncertain significance
rs2059311834	20:58,440,496	A/G	—	uncertain significance
rs374889210	20:58,440,645	T/C	—	uncertain significance
rs539397918	20:58,440,681	C/T	—	uncertain significance
rs151218291	20:58,440,873	G/A	—	likely benign
rs2517062642	20:58,441,419	T/A	—	uncertain significance
rs759695171	20:58,441,420	G/A	—	likely benign
rs200463772	20:58,441,564	T/G	—	uncertain significance
rs58905758	20:58,441,612	C/T	—	benign
rs1292236161	20:58,442,843	G/T	—	uncertain significance
rs78462832	20:58,442,868	G/A	—	benign
rs138619417	20:58,442,888	A/G	—	uncertain significance
rs371026312	20:58,443,486	C/G	—	uncertain significance
rs2517085690	20:58,443,593	A/C	—	uncertain significance
rs148819194	20:58,443,602	C/T	—	uncertain significance
rs546673434	20:58,444,950	T/C	—	uncertain significance
rs765145557	20:58,444,959	T/C	—	uncertain significance
rs369785647	20:58,444,983	G/T	—	uncertain significance
rs186581352	20:58,444,996	T/C	—	uncertain significance
rs770240988	20:58,444,998	C/T	—	uncertain significance
rs201347709	20:58,445,038	G/A	—	uncertain significance
rs758613217	20:58,448,975	T/C	—	uncertain significance
rs771682701	20:58,449,006	C/T	—	uncertain significance
rs141596387	20:58,449,010	G/A	—	likely benign
rs138418751	20:58,449,059	G/C	—	uncertain significance
rs1397751990	20:58,450,514	A/C	—	uncertain significance
rs2517180433	20:58,452,519	T/A	—	uncertain significance
rs200195809	20:58,452,528	G/T	—	uncertain significance
rs780437112	20:58,452,535	T/A	—	uncertain significance
rs61741892	20:58,452,567	G/A	—	benign
rs147607148	20:58,452,594	A/G	—	uncertain significance
rs189451142	20:58,453,674	T/C	intron variant	—
rs115051019	20:58,455,414	T/C	—	benign
rs201450022	20:58,455,429	G/A	—	uncertain significance
rs151163205	20:58,455,447	A/G	—	benign
rs140240953	20:58,455,451	C/T	—	uncertain significance
rs754213745	20:58,455,493	T/C	—	uncertain significance
rs369448872	20:58,455,513	T/C	—	uncertain significance
rs773971037	20:58,456,025	T/C	—	uncertain significance
rs967265727	20:58,457,171	T/C	—	uncertain significance
rs2059796201	20:58,461,789	C/T	—	uncertain significance
rs758919712	20:58,461,793	T/C	—	uncertain significance
rs142942464	20:58,461,802	T/C	—	benign
rs982493028	20:58,461,855	A/G	—	likely benign
rs2517266678	20:58,461,877	T/C	—	uncertain significance
rs193921008	20:58,461,897	A/G	—	uncertain significance
rs117549957	20:58,467,097	T/G	—	likely benign
rs139419328	20:58,467,147	G/C	—	uncertain significance
rs2517302195	20:58,467,170	T/C	—	uncertain significance
rs367901105	20:58,467,193	T/C	—	uncertain significance
rs542719581	20:58,467,194	A/G	—	uncertain significance
rs1217224488	20:58,467,197	T/C	—	uncertain significance
rs61730336	20:58,467,393	A/G	—	benign
rs761288072	20:58,467,478	A/G	—	uncertain significance
rs370577359	20:58,467,637	T/C	—	uncertain significance
rs182599987	20:58,467,663	G/C	—	uncertain significance
rs200064162	20:58,467,716	G/C	—	uncertain significance
rs747646328	20:58,468,198	T/A	—	uncertain significance
rs144624770	20:58,468,209	C/A	—	likely benign
rs761393974	20:58,470,514	T/C	—	uncertain significance
rs1358841241	20:58,470,587	T/A	—	uncertain significance
rs767964189	20:58,471,549	G/A	—	uncertain significance
rs757447008	20:58,471,570	C/T	—	uncertain significance
rs2517368697	20:58,475,224	T/C	—	uncertain significance
rs1372613888	20:58,475,809	C/T	—	uncertain significance
rs769761954	20:58,475,845	A/G	—	uncertain significance
rs2060118461	20:58,476,728	T/C	—	uncertain significance
rs750779924	20:58,476,741	T/G	—	uncertain significance
rs2517381414	20:58,476,752	C/G	—	uncertain significance
rs2517381658	20:58,476,776	C/T	—	uncertain significance
rs1256184496	20:58,476,834	A/C	—	uncertain significance
rs139880860	20:58,476,862	C/T	—	uncertain significance
rs2517415702	20:58,482,440	C/T	—	uncertain significance
rs752920084	20:58,482,443	T/C	—	uncertain significance
rs2517415867	20:58,482,467	C/G	—	uncertain significance
rs938568387	20:58,486,822	T/C	—	uncertain significance
rs2060334189	20:58,486,851	T/C	—	uncertain significance
rs1303648978	20:58,489,184	T/C	—	uncertain significance
rs2517469276	20:58,490,255	C/T	—	likely pathogenic
rs200205398	20:58,490,556	C/T	—	uncertain significance
rs774188429	20:58,490,588	A/C	—	uncertain significance
rs2517481810	20:58,491,540	C/A	—	likely pathogenic
rs768114400	20:58,491,593	C/T	—	uncertain significance
rs78182350	20:58,494,645	G/T	—	uncertain significance
rs774324923	20:58,495,462	C/G	—	uncertain significance
rs1453186978	20:58,495,469	C/T	—	uncertain significance
rs1385250296	20:58,495,499	A/G	—	uncertain significance
rs759339768	20:58,496,371	T/C	—	likely benign
rs61730337	20:58,496,438	A/G	—	benign
rs747977568	20:58,497,456	G/T	—	uncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.