TAF15

TATA-box binding protein associated factor 15

Summary

This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Known Variants106 total

rsidPosition (GRCh37)AllelesClassClinVar
rs11728199317:34,136,868G/A—likely benign
rs808095917:34,140,454G/T——
rs720951217:34,144,460A/G—benign
rs7439827917:34,144,518A/G—likely benign
rs11528221417:34,144,703C/A—likely benign
rs425173717:34,146,818C/A—benign
rs14103461317:34,147,190C/T—uncertain significance
rs19988822917:34,147,191G/A—likely benign
rs208724245717:34,147,211A/G—uncertain significance
rs11767730617:34,147,222G/A—likely benign
rs14737055717:34,147,320C/T—likely benign
rs19153889217:34,147,356G/T—likely benign
rs208724462717:34,147,374C/G—uncertain significance
rs92967531317:34,147,378G/T—uncertain significance
rs77510492117:34,147,399A/G—uncertain significance
rs99807861617:34,147,547A/T—likely benign
rs425173817:34,147,598G/A—likely benign
rs425174417:34,149,502A/G—benign
rs425174517:34,149,560G/A—benign
rs76694547617:34,149,667A/G—uncertain significance
rs20084131117:34,149,682A/G—uncertain significance
rs14060107117:34,149,718A/G—likely benign
rs77717655617:34,149,742A/C—uncertain significance
rs76533614417:34,149,769A/G—uncertain significance
rs76289108617:34,149,789C/A—uncertain significance
rs75594983017:34,149,799A/G—uncertain significance
rs425175217:34,150,904G/C—benign
rs425175317:34,150,975G/A—benign
rs425175517:34,151,078G/C—likely benign
rs20055787717:34,151,127A/G—uncertain significance
rs208729826617:34,151,195G/A—uncertain significance
rs378576417:34,160,764C/T—benign
rs7990999817:34,161,281A/G—benign
rs20104104317:34,161,520T/C—likely benign
rs11240782417:34,161,541T/C—likely benign
rs20194227317:34,161,574C/G—likely benign
rs13879046817:34,161,589C/T—likely benign
rs36849808017:34,161,608G/C—likely benign
rs14146261617:34,161,859C/A—likely benign
rs425176217:34,162,151G/Aupstream gene variant—
rs7654948617:34,162,842C/A—likely benign
rs14485135117:34,163,188G/A—likely benign
rs254415506517:34,163,244A/T—uncertain significance
rs376032717:34,163,387G/C—benign
rs425176617:34,163,397T/A—benign
rs423925217:34,163,565G/A—benign
rs14929305717:34,165,520C/T—benign
rs77092701217:34,165,567A/T—likely benign
rs425177217:34,165,594G/T—likely benign
rs989408317:34,169,155G/A—benign
rs214382655417:34,169,384T/A—uncertain significance
rs14452057717:34,169,391A/G—uncertain significance
rs57341479317:34,169,466A/G—likely benign
rs254416641517:34,171,086G/A—uncertain significance
rs425178117:34,171,222A/G—benign
rs425178217:34,171,259G/A—likely benign
rs77477996417:34,171,291G/A—uncertain significance
rs75796611817:34,171,333A/T—uncertain significance
rs14026855317:34,171,358G/A—benign
rs37578326717:34,171,367G/A—uncertain significance
rs425178417:34,171,452G/A—likely benign
rs7138148117:34,171,487G/A—uncertain significance
rs20017534717:34,171,525C/T—uncertain significance
rs94007532917:34,171,551C/A—likely benign
rs425178517:34,171,590A/G—benign
rs13938040317:34,171,617C/T—likely benign
rs123604564117:34,171,627A/T—uncertain significance
rs146887351517:34,171,634G/A—uncertain significance
rs15003464317:34,171,635C/T—benign
rs132182606017:34,171,647A/G—benign
rs14529535317:34,171,650C/T—benign
rs77054919517:34,171,661G/T—uncertain significance
rs130155965317:34,171,662T/C—benign
rs56092332717:34,171,667A/G—likely benign
rs77033468817:34,171,671T/A—likely benign
rs53007074517:34,171,674G/A—likely benign
rs14679293717:34,171,683C/A—likely benign
rs36939988017:34,171,686C/T—likely benign
rs37297093617:34,171,687G/A—uncertain significance
rs75635185617:34,171,691A/G—conflicting classifications of pathogenicity
rs11314544717:34,171,695T/A—likely benign
rs75254081417:34,171,698G/A—likely benign
rs140087359117:34,171,702A/C—likely benign
rs14048449317:34,171,707A/C—likely benign
rs56064147817:34,171,710C/T—likely benign
rs133987218417:34,171,715A/G—uncertain significance
rs77799337917:34,171,721G/A—uncertain significance
rs122797925017:34,171,727G/A—uncertain significance
rs14491087917:34,171,749T/C—benign
rs36860034217:34,171,750C/G—uncertain significance
rs75827837617:34,171,751G/A—uncertain significance
rs425178617:34,171,827C/T—benign
rs37034508917:34,171,838G/A—uncertain significance
rs90783390417:34,171,867T/C—uncertain significance
rs77580022117:34,171,886G/A—uncertain significance
rs76741743017:34,171,891G/A—uncertain significance
rs89924424117:34,171,906C/G—uncertain significance
rs53268337117:34,171,907G/A—uncertain significance
rs11435326917:34,171,927G/A—benign
rs37333486517:34,171,937G/A—uncertain significance

Showing 100 of 106 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.