TAF1B

TATA-box binding protein associated factor, RNA polymerase I subunit B

Summary

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Known Variants30 total

rsidPosition (GRCh37)AllelesClassClinVar
rs7555973622:9,985,394G/Tuncertain significance
rs3695602442:9,985,425C/Tuncertain significance
rs1807883512:9,985,443C/Tuncertain significance
rs25278621622:9,989,521A/Guncertain significance
rs25278669542:9,991,757C/Auncertain significance
rs7736848172:9,994,549C/Tuncertain significance
rs7474524572:10,008,477C/Guncertain significance
rs3771906332:10,008,496C/Tuncertain significance
rs7673763872:10,008,529C/Guncertain significance
rs16640648372:10,008,553A/Tuncertain significance
rs25279153462:10,016,035T/Guncertain significance
rs1507864702:10,016,042G/Auncertain significance
rs9980350412:10,016,125A/Guncertain significance
rs25279277532:10,022,863A/Guncertain significance
rs1475210862:10,022,903A/Guncertain significance
rs25279278732:10,022,923T/Cuncertain significance
rs1417768802:10,045,082A/Guncertain significance
rs1386515062:10,045,097T/Cuncertain significance
rs7558649872:10,050,876A/Cuncertain significance
rs3766405862:10,050,880T/Cuncertain significance
rs1503579432:10,050,942A/Guncertain significance
rs7638338132:10,051,680A/Guncertain significance
rs1509865112:10,059,732G/Auncertain significance
rs5418553542:10,059,774A/Glikely benign
rs2010513172:10,059,865T/Auncertain significance
rs2003996882:10,059,892A/Guncertain significance
rs7799721802:10,059,904C/Auncertain significance
rs341538482:10,072,750G/Aupstream gene variant
rs16662969422:10,074,027G/Auncertain significance
rs7674010142:10,074,066A/Cuncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.