TAF2

TATA-box binding protein associated factor 2

Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008]

Known Variants215 total

rsidPosition (GRCh37)AllelesClassClinVar
rs7557606708:120,744,186C/T—uncertain significance
rs7798366748:120,744,187G/A—uncertain significance
rs358304898:120,744,194C/T—benign
rs10398406638:120,744,214A/C—uncertain significance
rs24880611088:120,744,230C/T—likely benign
rs617562158:120,744,248G/A—likely benign
rs24880614008:120,744,250C/A—uncertain significance
rs24880617608:120,744,275A/C—uncertain significance
rs7557855008:120,744,286T/G—uncertain significance
rs617537478:120,744,293C/T—benign
rs10018640028:120,744,303T/G—uncertain significance
rs3724968638:120,744,316G/A—uncertain significance
rs12574415218:120,744,324T/C—uncertain significance
rs21309601368:120,744,328G/T—uncertain significance
rs9567488:120,744,349T/C—benign
rs9898475768:120,744,350A/G—likely benign
rs13592852238:120,744,371G/A—likely benign
rs18189162918:120,744,376G/A—uncertain significance
rs1401554828:120,744,380G/A—likely benign
rs1438032458:120,744,386C/T—likely benign
rs9567498:120,744,399C/T—benign
rs7534891078:120,744,415C/T—uncertain significance
rs7546500968:120,744,430C/G—uncertain significance
rs5759522278:120,744,952G/A—likely benign
rs13686819578:120,744,976C/A—likely benign
rs24881187108:120,754,759A/G—likely benign
rs5276958958:120,754,786G/A—uncertain significance
rs5464680258:120,754,791A/C—conflicting classifications of pathogenicity
rs2003975888:120,754,819T/G—uncertain significance
rs24881197578:120,754,850G/C—likely benign
rs13077273848:120,754,857A/G—uncertain significance
rs7474536358:120,754,866C/T—uncertain significance
rs7690653698:120,754,882G/A—uncertain significance
rs7518957478:120,754,889C/T—likely benign
rs24881302508:120,756,514A/G—likely benign
rs12344953978:120,756,522T/C—uncertain significance
rs7671916428:120,756,538C/T—likely benign
rs18198016758:120,756,565G/T—likely benign
rs7528346998:120,756,596T/C—uncertain significance
rs3752878888:120,756,618C/T—uncertain significance
rs13495940948:120,756,623G/A—uncertain significance
rs24881315158:120,756,626C/T—likely benign
rs7476199638:120,756,627T/C—uncertain significance
rs7782813938:120,758,980T/C—uncertain significance
rs1427356408:120,758,983G/C—benign
rs7467381778:120,758,990T/C—likely benign
rs7788127638:120,758,992C/T—uncertain significance
rs1151024968:120,759,062A/G—benign
rs7510376328:120,759,087A/C—uncertain significance
rs1422230518:120,759,108C/G—uncertain significance
rs10452365368:120,759,113G/T—likely benign
rs21310105688:120,759,135T/A—uncertain significance
rs18200152318:120,759,149C/T—likely benign
rs7458141248:120,759,161G/A—likely benign
rs7667527528:120,768,239C/G—likely benign
rs7636494978:120,768,254A/G—uncertain significance
rs1419614728:120,768,256A/G—likely benign
rs3677050718:120,768,297G/A—uncertain significance
rs7561098898:120,768,299G/A—uncertain significance
rs7611582318:120,768,331A/T—likely benign
rs3698071938:120,770,297T/C—likely benign
rs7501412908:120,770,318A/G—likely benign
rs3739175578:120,770,344T/C—uncertain significance
rs21310473278:120,770,370T/A—uncertain significance
rs1379402278:120,770,372A/C—uncertain significance
rs10416693838:120,772,820C/T—likely benign
rs9024427748:120,772,826T/C—likely benign
rs7651084468:120,772,827C/T—likely benign
rs1848916308:120,772,829A/G—likely benign
rs18209991128:120,772,883T/C—uncertain significance
rs5378914108:120,772,962G/A—uncertain significance
rs14460928428:120,772,982G/A—likely benign
rs12826377778:120,772,997A/G—likely benign
rs7504518438:120,774,682G/A—conflicting classifications of pathogenicity
rs1430041558:120,774,711G/A—likely benign
rs1174209058:120,774,755C/T—uncertain significance
rs12906211808:120,774,773T/C—uncertain significance
rs7618296748:120,774,802T/C—uncertain significance
rs7664331108:120,774,829C/T—uncertain significance
rs21310636228:120,774,833A/T—pathogenic
rs24882432978:120,774,840A/C—uncertain significance
rs24882434028:120,774,853G/A—likely benign
rs21310636928:120,774,859G/C—likely benign
rs7606006458:120,790,263T/G—uncertain significance
rs13653696818:120,790,283C/T—likely benign
rs15093488:120,790,304T/C—benign
rs14654530678:120,790,333G/A—uncertain significance
rs24883297618:120,790,367A/G—likely benign
rs7632358238:120,793,276T/C—likely benign
rs24883464748:120,793,287C/G—uncertain significance
rs70025018:120,793,296C/T—benign
rs286195388:120,793,332T/C—benign
rs7522954128:120,793,353A/G—likely benign
rs12530393958:120,793,354C/T—uncertain significance
rs24883473988:120,793,361A/C—uncertain significance
rs15864151858:120,793,365A/G—likely benign
rs10264956998:120,793,369A/C—uncertain significance
rs24883477848:120,793,407C/G—uncertain significance
rs18226250988:120,793,416C/T—likely benign
rs21311341058:120,793,433T/C—uncertain significance

Showing 100 of 215 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.