TAS2R38
taste 2 receptor member 38
Summary
This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]
Known Variants26 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs137902035 | 7:141,672,501 | C/G | — | uncertain significance |
| rs782154406 | 7:141,672,504 | G/C | — | uncertain significance |
| rs1554444315 | 7:141,672,530 | C/A | — | uncertain significance |
| rs2485580984 | 7:141,672,545 | A/G | — | likely benign |
| rs10246939 | 7:141,672,604 | C/T | missense variant | drug response |
| rs370225669 | 7:141,672,654 | A/T | — | uncertain significance |
| rs1726866 | 7:141,672,705 | G/A | missense variant | benign |
| rs1000902355 | 7:141,672,763 | T/C | — | uncertain significance |
| rs144212167 | 7:141,672,786 | C/T | — | uncertain significance |
| rs201169146 | 7:141,672,821 | G/T | — | uncertain significance |
| rs142321204 | 7:141,672,841 | T/G | — | uncertain significance |
| rs782642723 | 7:141,672,845 | C/T | — | uncertain significance |
| rs782588913 | 7:141,672,931 | T/C | — | uncertain significance |
| rs942592769 | 7:141,672,946 | G/A | — | likely benign |
| rs782368527 | 7:141,672,960 | T/C | — | uncertain significance |
| rs2485582256 | 7:141,672,998 | G/T | — | uncertain significance |
| rs1554444392 | 7:141,673,021 | G/A | — | uncertain significance |
| rs2485582335 | 7:141,673,023 | A/G | — | uncertain significance |
| rs1554444394 | 7:141,673,032 | A/T | — | uncertain significance |
| rs782034667 | 7:141,673,036 | A/C | — | uncertain significance |
| rs549418338 | 7:141,673,073 | C/G | — | uncertain significance |
| rs1803403621 | 7:141,673,199 | C/T | — | uncertain significance |
| rs2485582977 | 7:141,673,269 | C/G | — | uncertain significance |
| rs713598 | 7:141,673,345 | C/G | missense variant | drug response |
| rs2485583165 | 7:141,673,357 | C/T | — | uncertain significance |
| rs375588043 | 7:141,673,467 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.