TECTA

tectorin alpha

Summary

The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness. [provided by RefSeq, Jul 2008]

Known Variants931 total

rsidPosition (GRCh37)AllelesClassClinVar
rs7359945511:120,973,064A/C—benign
rs7961404511:120,973,274T/C—likely benign
rs5605828511:120,973,296A/C—benign
rs14591627911:120,973,362T/C—likely benign
rs159143347511:120,973,403G/C—likely benign
rs14039350811:120,973,407C/A—conflicting classifications of pathogenicity
rs213504651611:120,973,410T/G—uncertain significance
rs75646010811:120,973,419C/T—conflicting classifications of pathogenicity
rs213504654011:120,973,421C/T—uncertain significance
rs3550752211:120,973,430A/G—likely benign
rs55961090211:120,973,464C/T—likely benign
rs5635841411:120,973,516C/T—benign
rs11189787011:120,976,209A/G—likely benign
rs5568364011:120,976,311C/A—benign
rs68131111:120,976,413G/A—benign
rs50462611:120,976,428G/A—benign
rs11425649611:120,976,460G/A—likely benign
rs77491402411:120,976,521C/T—likely benign
rs20117106411:120,976,526A/G—conflicting classifications of pathogenicity
rs55930634411:120,976,549G/C—uncertain significance
rs37324808311:120,976,555T/C—uncertain significance
rs249688604311:120,976,559G/A—uncertain significance
rs57747072111:120,976,565A/T—conflicting classifications of pathogenicity
rs75077059911:120,976,588C/T—uncertain significance
rs194638550211:120,976,597T/C—uncertain significance
rs249688619911:120,976,615C/G—uncertain significance
rs144431825911:120,976,616T/A—likely benign
rs37428915911:120,976,635C/G—uncertain significance
rs213505027211:120,976,661C/T—likely benign
rs87665801511:120,976,662C/T—uncertain significance
rs77861040011:120,976,667T/C—likely benign
rs19088484011:120,976,707G/C—likely benign
rs55961972811:120,979,616G/C—likely benign
rs11462610011:120,979,841C/T—likely benign
rs141148053411:120,979,908T/C—likely benign
rs194642051611:120,979,910A/G—likely benign
rs37373641511:120,979,916G/A—likely benign
rs37305878811:120,979,917T/C—likely benign
rs194642075711:120,979,920G/C—uncertain significance
rs77970791911:120,979,931C/T—likely benign
rs76826758611:120,979,948A/G—uncertain significance
rs104549306511:120,979,950G/T—uncertain significance
rs213505481511:120,979,951T/C—uncertain significance
rs249689135611:120,979,953C/G—uncertain significance
rs14206453911:120,979,961C/T—likely benign
rs14589815811:120,979,969C/T—conflicting classifications of pathogenicity
rs77021496611:120,979,970G/A—likely benign
rs249689140811:120,979,981T/G—uncertain significance
rs13864657411:120,980,007G/C—uncertain significance
rs75033042011:120,980,009C/T—likely benign
rs75215952411:120,980,035A/G—uncertain significance
rs75468518711:120,980,044G/A—uncertain significance
rs72750483011:120,980,048C/T—conflicting classifications of pathogenicity
rs88604341211:120,980,057T/C—conflicting classifications of pathogenicity
rs75566717311:120,980,070A/G—benign
rs37658188111:120,980,076C/A—conflicting classifications of pathogenicity
rs37068894711:120,980,079G/T—uncertain significance
rs249689162611:120,980,087G/A—likely benign
rs137871657211:120,980,098C/T—uncertain significance
rs14109015111:120,980,141T/C—uncertain significance
rs97306352611:120,980,151G/A—uncertain significance
rs194642329711:120,980,169G/C—uncertain significance
rs194642332811:120,980,175G/C—uncertain significance
rs155512179911:120,980,179C/T—uncertain significance
rs127967923611:120,980,180G/A—likely benign
rs213505509211:120,980,191G/A—uncertain significance
rs77738188911:120,980,201C/G—likely benign
rs20067297011:120,983,762G/A—benign
rs36862741111:120,983,774C/G—likely benign
rs159143751611:120,983,787A/T—uncertain significance
rs75678992711:120,983,788C/T—uncertain significance
rs124348551211:120,983,811G/A—uncertain significance
rs127212970711:120,983,812A/G—uncertain significance
rs37141422411:120,983,821A/G—conflicting classifications of pathogenicity
rs74732493711:120,983,822T/C—uncertain significance
rs88604783511:120,983,827T/G—uncertain significance
rs76291242011:120,983,830C/T—uncertain significance
rs37428659311:120,983,831C/G—likely benign
rs37272391411:120,983,832C/T—uncertain significance
rs249689624211:120,983,839A/G—uncertain significance
rs14836486511:120,983,846C/T—conflicting classifications of pathogenicity
rs86783682011:120,983,847G/A—uncertain significance
rs77189907911:120,983,848A/G—uncertain significance
rs76387213211:120,983,862A/C—likely pathogenic
rs75349399011:120,983,863C/T—conflicting classifications of pathogenicity
rs74990040411:120,983,871G/A—uncertain significance
rs37218567311:120,983,879C/T—likely benign
rs75196088211:120,983,880G/A—uncertain significance
rs88604783611:120,983,882C/T—uncertain significance
rs213505946911:120,983,883G/A—uncertain significance
rs72750345611:120,983,895G/T—uncertain significance
rs194645925611:120,983,905G/A—uncertain significance
rs37510764711:120,983,907G/C—uncertain significance
rs77789591411:120,983,911T/C—uncertain significance
rs7359949211:120,983,929C/G—likely benign
rs229847811:120,984,087C/G—benign
rs77662977411:120,984,248C/T—likely benign
rs14200787911:120,984,258G/T—conflicting classifications of pathogenicity
rs76254444511:120,984,287C/T—uncertain significance
rs118069469411:120,984,302T/C—conflicting classifications of pathogenicity

Showing 100 of 931 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.