THBS2

thrombospondin 2

Summary

The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]

Known Variants108 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs8089	6:169,617,726	A/C	3 prime UTR variant	—
rs1215621645	6:169,617,915	G/A	—	likely benign
rs113625243	6:169,617,922	T/C	—	likely benign
rs59953407	6:169,620,363	G/A	—	benign
rs1132742	6:169,621,536	A/G	—	benign
rs61730648	6:169,621,542	G/C	—	benign
rs140852957	6:169,621,600	A/G	—	benign
rs2483438621	6:169,621,610	A/C	—	uncertain significance
rs139254686	6:169,622,299	G/A	—	benign
rs1166734303	6:169,622,322	C/T	—	likely benign
rs33925221	6:169,622,325	G/A	—	benign
rs142051087	6:169,622,349	C/T	—	benign
rs767991056	6:169,622,382	G/A	—	likely benign
rs141219768	6:169,622,399	G/A	—	uncertain significance
rs1350658095	6:169,622,401	G/A	—	uncertain significance
rs769462618	6:169,622,483	C/T	—	uncertain significance
rs9505895	6:169,622,490	G/A	—	benign
rs138932100	6:169,622,491	G/A	—	benign
rs138262723	6:169,622,555	C/T	—	uncertain significance
rs7341189	6:169,622,734	G/A	intron variant	—
rs35671519	6:169,623,350	G/A	—	benign
rs2483444512	6:169,623,366	T/C	—	uncertain significance
rs74507247	6:169,624,770	G/T	—	—
rs73043857	6:169,624,900	A/G	regulatory region variant	—
rs61739589	6:169,625,295	G/A	—	benign
rs184952882	6:169,625,300	C/T	—	likely benign
rs145307568	6:169,625,307	G/A	—	benign
rs2483451503	6:169,625,327	A/G	—	pathogenic
rs577405635	6:169,625,330	C/T	—	likely benign
rs149756243	6:169,625,333	C/T	—	uncertain significance
rs758674663	6:169,625,369	C/T	—	uncertain significance
rs373287450	6:169,625,378	T/G	—	uncertain significance
rs776247064	6:169,625,422	A/G	—	uncertain significance
rs1471486124	6:169,625,429	C/T	—	uncertain significance
rs752133535	6:169,625,468	C/T	—	likely benign
rs145039765	6:169,626,325	C/T	—	benign
rs368102843	6:169,628,312	C/T	—	uncertain significance
rs143333491	6:169,629,676	G/C	—	likely benign
rs148360643	6:169,629,697	G/A	—	likely benign
rs140600818	6:169,629,723	C/T	—	likely benign
rs35716236	6:169,629,724	G/A	—	benign
rs6422747	6:169,629,783	G/A	intron variant	benign
rs6422748	6:169,629,910	G/C	regulatory region variant	—
rs2483474223	6:169,632,097	T/C	—	uncertain significance
rs765474374	6:169,632,110	C/A	—	uncertain significance
rs770309229	6:169,632,173	C/T	—	uncertain significance
rs1474976569	6:169,632,191	C/T	—	uncertain significance
rs2483474877	6:169,632,197	T/C	—	uncertain significance
rs143976396	6:169,632,217	T/A	—	benign
rs35935937	6:169,632,219	A/G	—	benign
rs375967631	6:169,632,794	C/T	—	uncertain significance
rs1779890003	6:169,632,808	C/A	—	uncertain significance
rs1405048230	6:169,633,059	C/A	—	uncertain significance
rs1323254109	6:169,633,085	G/A	—	uncertain significance
rs61736308	6:169,633,093	G/C	—	benign
rs147420892	6:169,634,880	C/T	—	uncertain significance
rs34987335	6:169,634,896	A/G	—	benign
rs139510773	6:169,634,936	C/T	—	uncertain significance
rs772477090	6:169,634,975	G/A	—	uncertain significance
rs9406328	6:169,635,010	G/A	splice region variant	risk factor
rs765839973	6:169,637,276	G/T	—	uncertain significance
rs781465215	6:169,637,301	G/A	—	uncertain significance
rs2483506410	6:169,637,331	T/C	—	uncertain significance
rs2483506582	6:169,637,373	T/C	—	uncertain significance
rs148970069	6:169,637,723	G/A	—	conflicting classifications of pathogenicity
rs762675758	6:169,637,753	G/A	—	uncertain significance
rs9766671	6:169,637,763	G/C	—	benign
rs144973525	6:169,637,792	C/G	—	uncertain significance
rs2483510059	6:169,637,836	A/G	—	uncertain significance
rs35631991	6:169,637,847	A/G	—	benign
rs376028273	6:169,639,685	G/A	—	likely benign
rs369303414	6:169,639,718	C/T	—	uncertain significance
rs770906206	6:169,639,721	C/T	—	uncertain significance
rs6925000	6:169,639,746	G/T	—	benign
rs1013908512	6:169,639,755	C/T	—	likely benign
rs758612535	6:169,640,560	G/A	—	uncertain significance
rs1391628029	6:169,640,629	A/G	—	uncertain significance
rs2483522832	6:169,640,681	C/T	—	uncertain significance
rs148807753	6:169,640,686	G/A	—	benign
rs368185880	6:169,641,859	C/A	—	uncertain significance
rs751608764	6:169,641,860	T/A	—	uncertain significance
rs199802178	6:169,641,942	G/A	—	uncertain significance
rs577401935	6:169,641,945	C/A	—	uncertain significance
rs756790082	6:169,641,958	C/T	—	uncertain significance
rs201478863	6:169,641,960	G/A	—	uncertain significance
rs61730651	6:169,641,971	T/C	—	benign
rs142711993	6:169,641,991	C/T	—	likely benign
rs779223586	6:169,642,014	C/T	—	likely benign
rs748691484	6:169,642,017	A/C	—	uncertain significance
rs368747793	6:169,642,041	G/T	—	uncertain significance
rs202062355	6:169,642,042	C/T	missense variant	—
rs76393784	6:169,646,282	A/T	—	benign
rs148981005	6:169,646,314	C/G	—	uncertain significance
rs2483557258	6:169,646,346	C/G	—	uncertain significance
rs201754542	6:169,646,361	C/T	—	uncertain significance
rs113118914	6:169,648,595	C/A	—	uncertain significance
rs117760328	6:169,648,602	G/A	—	benign
rs144067288	6:169,648,646	C/T	—	likely benign
rs141150786	6:169,648,662	G/A	—	likely benign
rs373775267	6:169,648,698	G/C	—	uncertain significance

Showing 100 of 108 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.